{"id":"https://openalex.org/W2002903936","doi":"https://doi.org/10.1016/s0140-6736(87)91034-8","title":"LOW FREQUENCY OF SLOW DEBRISOQUINE HYDROXYLATION IN A NATIVE CHINESE POPULATION","display_name":"LOW FREQUENCY OF SLOW DEBRISOQUINE HYDROXYLATION IN A NATIVE CHINESE POPULATION","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2002903936","doi":"https://doi.org/10.1016/s0140-6736(87)91034-8","mag":"2002903936","pmid":"https://pubmed.ncbi.nlm.nih.gov/2889047"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(87)91034-8","doi":"https://doi.org/10.1016/s0140-6736(87)91034-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(87)91034-8","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113529651","display_name":"Ya-Ching Lou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Ching Lou","raw_affiliation_strings":["Department of Pharmacology, Beijing Medical University, Baijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Beijing Medical University, Baijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liu Ying","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu Ying","raw_affiliation_strings":["Department of Pharmacology, Beijing Medical University, Baijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Beijing Medical University, Baijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111567063","display_name":"Leif Bertilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Bertilsson","raw_affiliation_strings":["Department of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","Dept of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Dept of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112137575","display_name":"Folke Sj\u00f6qvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"F. Sjoqvist","raw_affiliation_strings":["Department of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","Dept of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Dept of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":6.0211,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96854167,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"330","issue":"8563","first_page":"852","last_page":"853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/debrisoquine-hydroxylation","display_name":"debrisoquine hydroxylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.7720000147819519},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.41200000047683716},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7620000243186951},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.9774850606918335},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.6827332377433777},{"id":"https://openalex.org/C3020640247","wikidata":"https://www.wikidata.org/wiki/Q1981379","display_name":"Chinese population","level":4,"score":0.4620811939239502},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4607250988483429},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3691878318786621},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3414722681045532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30000004172325134},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.16323024034500122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1620100438594818},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14057305455207825},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13250049948692322},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06545892357826233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06506437063217163}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D003647","descriptor_name":"Debrisoquin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(87)91034-8","doi":"https://doi.org/10.1016/s0140-6736(87)91034-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(87)91034-8","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:2889047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2889047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W109491134","https://openalex.org/W1972572857","https://openalex.org/W1979392961","https://openalex.org/W2014659745","https://openalex.org/W2035675075","https://openalex.org/W2418557697"],"related_works":["https://openalex.org/W1997594746","https://openalex.org/W2042982427","https://openalex.org/W1991932809","https://openalex.org/W2078386303","https://openalex.org/W1987875287","https://openalex.org/W2057927313","https://openalex.org/W2164151023","https://openalex.org/W1983638955","https://openalex.org/W2006240173","https://openalex.org/W2143417317"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
