{"id":"https://openalex.org/W2002889115","doi":"https://doi.org/10.1055/s-2007-1009309","title":"Involvement of Adrenergic Mechanism in Hyperglycemia Due to SCN Stimulation","display_name":"Involvement of Adrenergic Mechanism in Hyperglycemia Due to SCN Stimulation","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2002889115","doi":"https://doi.org/10.1055/s-2007-1009309","mag":"2002889115","pmid":"https://pubmed.ncbi.nlm.nih.gov/2575573"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-1009309","doi":"https://doi.org/10.1055/s-2007-1009309","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-1009309","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112271285","display_name":"Takando FUJII","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Fujii","raw_affiliation_strings":["Third Department of Internal Medicine, Yokohama City University, Japan","Third Department of Internal Medicine, Yokohama City University, Yokohama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Yokohama City University, Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Third Department of Internal Medicine, Yokohama City University, Yokohama","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993038","display_name":"Shuji Inoue","orcid":"https://orcid.org/0009-0004-3382-6113","observed_orcids":["https://orcid.org/0009-0004-3382-6113"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Inoue","raw_affiliation_strings":["Third Department of Internal Medicine, Yokohama City University, Yokohama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Yokohama City University, Yokohama","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109961477","display_name":"Katsuya Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Nagai","raw_affiliation_strings":["Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110026156","display_name":"Hachiro Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Nakagawa","raw_affiliation_strings":["Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2425,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.39165391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"21","issue":"12","first_page":"643","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.4438000023365021,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hyperglucagonemia","display_name":"hyperglucagonemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hexamethonium","display_name":"hexamethonium","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bunazosin","display_name":"bunazosin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamic-electrical-stimulation","display_name":"hypothalamic electrical stimulation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8299384117126465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8212584257125854},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6605727672576904},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6489585638046265},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.6133756637573242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4106069505214691},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4105416536331177},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12973743677139282},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006584","descriptor_name":"Hexamethonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015016","descriptor_name":"Yohimbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018738","descriptor_name":"Hexamethonium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2007-1009309","doi":"https://doi.org/10.1055/s-2007-1009309","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-1009309","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:2575573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2575573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1649524900","https://openalex.org/W2094080002","https://openalex.org/W2093146788","https://openalex.org/W2415621998","https://openalex.org/W1997463807","https://openalex.org/W4221023412","https://openalex.org/W2055483654","https://openalex.org/W2734889391","https://openalex.org/W2006630835","https://openalex.org/W4220806282"],"abstract_inverted_index":{"Previously":[0],"we":[1,31],"found":[2],"that":[3,101],"in":[4,109],"rats,":[5],"electrical":[6,56],"stimulation":[7,57],"of":[8,13,28,35,37,58,76],"the":[9,14,26,33,38,50,59,74,82,85,96,110],"suprachiasmatic":[10],"nucleus":[11],"(SCN)":[12],"hypothalamus":[15],"elicited":[16],"hyperglycemia":[17],"associated":[18],"with":[19],"hyperglucagonemia":[20],"without":[21],"immediate":[22],"hyperinsulinemia.":[23],"To":[24],"clarify":[25],"mechanism":[27],"these":[29,43],"responses,":[30],"examined":[32],"effects":[34],"blockers":[36],"autonomic":[39],"nervous":[40],"system":[41],"on":[42],"responses.":[44,89,97],"Hexamethonium,":[45],"a":[46,91],"ganglion":[47],"blocker,":[48,66,72,93],"suppressed":[49,84],"hyperglycemic":[51,86,111],"and":[52,67,87,104,112],"hyperglucagonemic":[53,88,113],"responses":[54,114],"to":[55,115],"SCN.":[60],"Both":[61],"bunazosin,":[62],"an":[63,69],"alpha":[64,70,102],"1-adrenergic":[65],"yohimbin,":[68],"2-adrenergic":[71],"increased":[73],"level":[75],"insulin":[77],"before":[78],"stimulation,":[79],"but":[80],"only":[81],"latter":[83],"Propranolol,":[90],"beta-adrenergic":[92,105],"partially":[94],"inhibited":[95],"These":[98],"findings":[99],"suggest":[100],"2-":[103],"mechanisms":[106],"are":[107],"involved":[108],"SCN":[116],"stimulation.":[117]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
