{"id":"https://openalex.org/W2002865233","doi":"https://doi.org/10.1080/095530098141573","title":"A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes","display_name":"A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2002865233","doi":"https://doi.org/10.1080/095530098141573","mag":"2002865233","pmid":"https://pubmed.ncbi.nlm.nih.gov/9712548"},"language":"en","primary_location":{"id":"doi:10.1080/095530098141573","doi":"https://doi.org/10.1080/095530098141573","is_oa":false,"landing_page_url":"https://doi.org/10.1080/095530098141573","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105986180","display_name":"Rainer K. Sachs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RAINER K.SACHS","raw_affiliation_strings":["Departm ent of Mathematics, University of California, Berkeley , CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departm ent of Mathematics, University of California, Berkeley , CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048201953","display_name":"David J. Brenner","orcid":"https://orcid.org/0000-0002-0926-1210","observed_orcids":["https://orcid.org/0000-0002-0926-1210"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID J.BRENNER","raw_affiliation_strings":["Center for Radiological Research, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082159954","display_name":"Philip Hahnfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PHILIP J.HAHNFELDT","raw_affiliation_strings":["Joint Center for Radiation Therapy , Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Radiation Therapy , Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038286698","display_name":"LYNN R. HLATKYS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LYNN R. HLATKYS","raw_affiliation_strings":["Joint Center for Radiation Therapy , Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Radiation Therapy , Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9517,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85160716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"74","issue":"2","first_page":"185","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9279999732971191},{"id":"https://openalex.org/keywords/high-let-radiation","display_name":"high-LET radiation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dna-fragment-size-distribution","display_name":"DNA fragment size distribution","score":0.7250000238418579},{"id":"https://openalex.org/keywords/track-structure","display_name":"track structure","score":0.722000002861023},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pulsed-field-gel-electrophoresis","display_name":"pulsed-field gel electrophoresis","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6388475894927979},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6094356179237366},{"id":"https://openalex.org/C2779015675","wikidata":"https://www.wikidata.org/wiki/Q92796261","display_name":"Breakage","level":2,"score":0.6048489212989807},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.6016333103179932},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.543779730796814},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5137144327163696},{"id":"https://openalex.org/C73301696","wikidata":"https://www.wikidata.org/wiki/Q5469984","display_name":"Formalism (music)","level":3,"score":0.4654686450958252},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.4544244110584259},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4345259666442871},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.36017757654190063},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3598198890686035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.340098112821579},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31348133087158203},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.17210212349891663},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11319595575332642},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10516467690467834},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08990809321403503},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C558565934","wikidata":"https://www.wikidata.org/wiki/Q2743","display_name":"Musical","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000512","descriptor_name":"Alpha Particles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D018499","descriptor_name":"Linear Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019457","descriptor_name":"Chromosome Breakage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/095530098141573","doi":"https://doi.org/10.1080/095530098141573","is_oa":false,"landing_page_url":"https://doi.org/10.1080/095530098141573","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:9712548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9712548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.531.766","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.531.766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.columbia.edu/~djb3/papers/ijrb2.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G382702994","display_name":null,"funder_award_id":"RR-11623","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3950438931","display_name":"RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)","funder_award_id":"P41RR011623","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3971674455","display_name":null,"funder_award_id":"ES-07361","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4212966161","display_name":null,"funder_award_id":"GM 57245","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G720110961","display_name":"CHROMATIN GEOMETRY AND INTRACHANGE PROXIMITY EFFECTS","funder_award_id":"R01GM057245","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G959809633","display_name":"BIOMARKER OF PRIOR ALPHA-PARTICLE OR NEUTRON EXPOSURE","funder_award_id":"R01ES007361","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1678621298","https://openalex.org/W1971687599","https://openalex.org/W1973023456","https://openalex.org/W1976108918","https://openalex.org/W1989328219","https://openalex.org/W1996845299","https://openalex.org/W2003689713","https://openalex.org/W2012842652","https://openalex.org/W2023508619","https://openalex.org/W2025125384","https://openalex.org/W2038889579","https://openalex.org/W2050420165","https://openalex.org/W2055691598","https://openalex.org/W2057701175","https://openalex.org/W2062375412","https://openalex.org/W2068449224","https://openalex.org/W2076314599","https://openalex.org/W2091373076","https://openalex.org/W2101613112","https://openalex.org/W2105648889","https://openalex.org/W2108141626","https://openalex.org/W2125304115","https://openalex.org/W2127359333","https://openalex.org/W2129176270","https://openalex.org/W2153302324","https://openalex.org/W2164937756","https://openalex.org/W2169643691","https://openalex.org/W2318767665","https://openalex.org/W2320670611","https://openalex.org/W2321187204","https://openalex.org/W2328175152","https://openalex.org/W2484420323","https://openalex.org/W2626425857","https://openalex.org/W2798023765","https://openalex.org/W4247171147","https://openalex.org/W4301082185","https://openalex.org/W4321258548","https://openalex.org/W6932044751"],"related_works":["https://openalex.org/W2022289931","https://openalex.org/W2125129609","https://openalex.org/W2168739147","https://openalex.org/W2084273927","https://openalex.org/W2110324506","https://openalex.org/W2403047142","https://openalex.org/W2105359138","https://openalex.org/W2096545136","https://openalex.org/W2463790931","https://openalex.org/W2027586525"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"model":[2,55],"intrachromosomal":[3],"clustering":[4,27,260],"of":[5,46,70,146,154,167,172,182,190,216,235],"DSB":[6,16,71,184,191,202,205,217,259],"(DNA":[7],"double":[8],"strand":[9],"breaks)":[10],"induced":[11],"by":[12,36,105,222,271],"ionizing":[13],"radiation.":[14],"That":[15],"are":[17,114,126,203,207,219],"located":[18],"non-randomly":[19],"along":[20,73,261],"chromosomes":[21],"after":[22],"high":[23,253],"LET":[24,173],"irradiation,":[25],"with":[26,170],"even":[28],"at":[29,210],"extremely":[30],"large":[31,256],"scales,":[32],"has":[33],"been":[34],"confirmed":[35],"recent":[37],"pulsed":[38],"field":[39],"gel":[40],"electrophoresis":[41],"data":[42,148,164],"for":[43,56,156,165,233,252],"size":[44,238],"distributions":[45,59,113],"DNA":[47,57,92],"fragments.":[48],"We":[49],"therefore":[50],"extend":[51],"the":[52,91,118,150,213,272],"standard":[53],"random-breakage":[54],"fragment-size":[58,93,112],"to":[60,96,134,149,161,194],"a":[61,74,86,97,102,180,188,195,236],"more":[62],"general":[63],"'clustered-breakage'":[64],"formalism,":[65],"which":[66,263],"can":[67,250],"take":[68],"correlations":[69],"locations":[72],"chromosome":[75],"into":[76,226],"account.":[77],"METHODS:":[78],"The":[79,129,229],"new":[80],"formalism":[81,131],"is":[82,132,268],"based":[83],"mainly":[84],"on":[85],"one-track":[87,119],"probability":[88],"distribution,":[89,120],"describing":[90],"pattern":[94,103,181],"due":[95],"single":[98],"primary":[99],"high-energy":[100],"particle,":[101],"determined":[104],"track":[106,141],"structure":[107],"and":[108,138,192,255],"chromatin":[109,199],"geometry.":[110],"Multi-track":[111],"derived":[115],"mathematically":[116],"from":[117,243],"so":[121],"that":[122],"dose":[123,230],"response":[124,231],"relations":[125],"obtained.":[127],"RESULTS:":[128],"clustered-breakage":[130,273],"applicable":[133],"any":[135,139],"chromosomal":[136],"geometry":[137],"radiation":[140],"structure.":[142],"It":[143],"facilitates":[144],"extrapolations":[145],"high-dose":[147],"much":[151],"lower":[152],"doses":[153,254],"interest":[155],"most":[157],"applications.":[158],"When":[159],"applied":[160],"recently":[162],"published":[163],"irradiation":[166],"mammalian":[168],"cells":[169],"ions":[171],"approximately":[174],"100":[175],"keV":[176],"microm(-1)":[177],"it":[178],"indicates":[179],"Mbp-scale":[183],"clusters,":[185],"each":[186],"containing":[187],"number":[189],"corresponding":[193],"very":[196],"large-scale,":[197],"multiply-damaged":[198],"site.":[200],"Although":[201],"bunched,":[204],"clusters":[206,225,242],"scattered":[208],"almost":[209],"random":[211],"throughout":[212],"genome.":[214],"Estimates":[215],"yield":[218],"markedly":[220],"increased":[221],"resolving":[223],"such":[224],"individual":[227],"DSB.":[228],"relation":[232],"fragments":[234],"given":[237],"becomes":[239],"non-linear":[240],"when":[241],"different":[244],"tracks":[245],"interlace":[246],"or":[247],"adjoin,":[248],"as":[249],"occur":[251],"sizes.":[257],"CONCLUSIONS:":[258],"chromosomes,":[262],"influences":[264],"important":[265],"radiobiological":[266],"endpoints,":[267],"described":[269],"quantitatively":[270],"formalism.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
