{"id":"https://openalex.org/W2002845950","doi":"https://doi.org/10.1016/j.bcp.2014.08.007","title":"The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells","display_name":"The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells","publication_year":2014,"publication_date":"2014-08-15","ids":{"openalex":"https://openalex.org/W2002845950","doi":"https://doi.org/10.1016/j.bcp.2014.08.007","mag":"2002845950","pmid":"https://pubmed.ncbi.nlm.nih.gov/25130545"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2014.08.007","doi":"https://doi.org/10.1016/j.bcp.2014.08.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2014.08.007","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083164845","display_name":"Ang\u00e9lique Pabois","orcid":"https://orcid.org/0000-0002-1289-1192","observed_orcids":["https://orcid.org/0000-0002-1289-1192"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ang\u00e9lique Pabois","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024746281","display_name":"Julie Devalli\u00e8re","orcid":"https://orcid.org/0000-0001-6935-5561","observed_orcids":["https://orcid.org/0000-0001-6935-5561"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Devalli\u00e8re","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056030022","display_name":"Thibaut Quillard","orcid":"https://orcid.org/0000-0002-8096-2597","observed_orcids":["https://orcid.org/0000-0002-8096-2597"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thibaut Quillard","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025810004","display_name":"Flora Coulon","orcid":"https://orcid.org/0000-0002-4135-8792","observed_orcids":["https://orcid.org/0000-0002-4135-8792"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Flora Coulon","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062186392","display_name":"Nathalie G\u00e9rard","orcid":"https://orcid.org/0000-0002-8818-1736","observed_orcids":["https://orcid.org/0000-0002-8818-1736"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie G\u00e9rard","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840040","display_name":"Christian L. LABOISSE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Laboisse","raw_affiliation_strings":["LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France; Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France; Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I3019204325","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083653617","display_name":"Claire S. Toquet","orcid":"https://orcid.org/0000-0003-0202-4420","observed_orcids":["https://orcid.org/0000-0003-0202-4420"]},"institutions":[{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Toquet","raw_affiliation_strings":["LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France; Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France; Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I3019204325","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"Service d'Anatomie Pathologique, CHU de Nantes, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049578005","display_name":"B\u00e9atrice L. Charreau","orcid":"https://orcid.org/0000-0001-5870-4615","observed_orcids":["https://orcid.org/0000-0001-5870-4615"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I234216984","display_name":"Universit\u00e9 Nantes Angers Le Mans","ror":"https://ror.org/0406t3m57","country_code":"FR","type":"education","lineage":["https://openalex.org/I234216984"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210112643","display_name":"Institut de Transplantation Urologie en Nephrologie","ror":"https://ror.org/02dm0bq25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210112643"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B\u00e9atrice Charreau","raw_affiliation_strings":["INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France. Electronic address: Beatrice.Charreau@univ-nantes.fr","CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France"],"raw_orcid":"https://orcid.org/0000-0001-5870-4615","affiliations":[{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France; CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France; LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France. Electronic address: Beatrice.Charreau@univ-nantes.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"raw_affiliation_string":"CHU de Nantes, Institut de Transplantation-Urologie-N\u00e9phrologie, ITUN, Nantes F44000, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I4210112643"]},{"raw_affiliation_string":"INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie, LabEx IGO and LabEx Transplantex, Nantes F44000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198"]},{"raw_affiliation_string":"LUNAM, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, Nantes F44000, France","institution_ids":["https://openalex.org/I234216984","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049578005"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I234216984","https://openalex.org/I3019204325","https://openalex.org/I4210112643","https://openalex.org/I4392021198","https://openalex.org/I4405260337","https://openalex.org/I97188460"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.9884,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.71128881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"91","issue":"4","first_page":"510","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.11670000106096268,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":1.0},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dll1","display_name":"DLL1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9390000104904175},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hey1","display_name":"Hey1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.7369999885559082},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/svcam-1","display_name":"sVCAM-1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9639999866485596},{"id":"https://openalex.org/keywords/immune-cell-recruitment","display_name":"immune cell recruitment","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cardiac-endothelium","display_name":"cardiac endothelium","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.9153938293457031},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.8298009634017944},{"id":"https://openalex.org/C2778715156","wikidata":"https://www.wikidata.org/wiki/Q17709536","display_name":"ADAM10","level":5,"score":0.7610599994659424},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6084454655647278},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5174787044525146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49789953231811523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42803144454956055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3674977123737335},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33365121483802795},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27348119020462036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1640806794166565}],"mesh":[{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bcp.2014.08.007","doi":"https://doi.org/10.1016/j.bcp.2014.08.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2014.08.007","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:25130545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25130545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-02163186v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-02163186","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Pharmacology, 2014, 91 (4), pp.510-521. ⟨10.1016/j.bcp.2014.08.007⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1990583350","display_name":"Nouveaux loci d'histocompatibilit\u00e9/biomarqueurs en transplantation humaine: de la d\u00e9couverte \u00e0 l'app","funder_award_id":"ANR-11-LABX-0070","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2184907896","display_name":"Par-del\u00e0 les fronti\u00e8res, l'Universit\u00e9 de Strasbourg","funder_award_id":"ANR-10-IDEX-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2942512633","display_name":"Centre Europ\u00e9en des Sciences de la Transplantation et de l\u2019Immunoth\u00e9rapie (TSI-IHU)","funder_award_id":"ANR-10-IBHU-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4110203128","display_name":"Immunoth\u00e9rapies Grand Ouest","funder_award_id":"ANR-11-LABX-0016","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1642299696","https://openalex.org/W1963691526","https://openalex.org/W1965963514","https://openalex.org/W1968558772","https://openalex.org/W1969414295","https://openalex.org/W1973333497","https://openalex.org/W1977514835","https://openalex.org/W1978097298","https://openalex.org/W1983867285","https://openalex.org/W1984285951","https://openalex.org/W1995943903","https://openalex.org/W1997642891","https://openalex.org/W1999505837","https://openalex.org/W2001215382","https://openalex.org/W2005930328","https://openalex.org/W2014925513","https://openalex.org/W2015976252","https://openalex.org/W2024424639","https://openalex.org/W2027679136","https://openalex.org/W2034458870","https://openalex.org/W2035259560","https://openalex.org/W2041309570","https://openalex.org/W2047813645","https://openalex.org/W2052306889","https://openalex.org/W2058734213","https://openalex.org/W2064489090","https://openalex.org/W2073465941","https://openalex.org/W2078320770","https://openalex.org/W2082184328","https://openalex.org/W2107277218","https://openalex.org/W2111314225","https://openalex.org/W2111412643","https://openalex.org/W2123414624","https://openalex.org/W2129270491","https://openalex.org/W2130454420","https://openalex.org/W2137689446","https://openalex.org/W2140836243","https://openalex.org/W2141117834","https://openalex.org/W2145738273","https://openalex.org/W2149152049","https://openalex.org/W2154542454","https://openalex.org/W2154861644","https://openalex.org/W2159110897","https://openalex.org/W2165070991","https://openalex.org/W2166225419","https://openalex.org/W2171476567","https://openalex.org/W2171783221","https://openalex.org/W4285719527","https://openalex.org/W6646506530","https://openalex.org/W6676785738"],"related_works":["https://openalex.org/W1167896752","https://openalex.org/W2255147830","https://openalex.org/W2773073002","https://openalex.org/W1978097298","https://openalex.org/W6955311000","https://openalex.org/W1167785751","https://openalex.org/W2112313218","https://openalex.org/W2014925513","https://openalex.org/W2460466663","https://openalex.org/W2901167659"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}