{"id":"https://openalex.org/W20028217","doi":"https://doi.org/10.1007/978-1-59259-718-5_12","title":"Validation of the Cytosensor\u2122 Microphysiometer for In Vitro Cytotoxicity Testing","display_name":"Validation of the Cytosensor\u2122 Microphysiometer for In Vitro Cytotoxicity Testing","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W20028217","doi":"https://doi.org/10.1007/978-1-59259-718-5_12","mag":"20028217"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-718-5_12","doi":"https://doi.org/10.1007/978-1-59259-718-5_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-718-5_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity Assessment Alternatives","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2496301051","display_name":"Toxicity Assessment Alternatives"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026605380","display_name":"Robert J. Mioduszewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. Mioduszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C. J. Cao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. J. Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110322797","display_name":"Mohyee E. Eldefrawi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. E. Eldefrawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110107924","display_name":"Amira Toppozada Eldefrawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. T. Eldefrawi","raw_affiliation_strings":["Rutgers University, Camden, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers University, Camden, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064816682","display_name":"Darrel E. Menking","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. E. Menking","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068641535","display_name":"James J. Vald\u00e9s","orcid":"https://orcid.org/0000-0002-0237-8061","observed_orcids":["https://orcid.org/0000-0002-0237-8061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. J. Valdes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00490196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"143","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vitro-cytotoxicity-testing","display_name":"in vitro cytotoxicity testing","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alternative-toxicity-testing","display_name":"alternative toxicity testing","score":0.7310000061988831},{"id":"https://openalex.org/keywords/reduction-of-animal-testing","display_name":"animal testing reduction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/human-risk-assessment","display_name":"human risk assessment","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6442251205444336},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.536481499671936},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5167959928512573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5013096332550049},{"id":"https://openalex.org/C2779717098","wikidata":"https://www.wikidata.org/wiki/Q131207","display_name":"Cosmetics","level":2,"score":0.4585322141647339},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.4256266951560974},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35256633162498474},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3426121473312378},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3215170204639435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30214953422546387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2887541651725769},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11347100138664246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07816103100776672},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-718-5_12","doi":"https://doi.org/10.1007/978-1-59259-718-5_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-718-5_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity Assessment Alternatives","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2004270772","https://openalex.org/W2023123970","https://openalex.org/W2035984904","https://openalex.org/W2036213823","https://openalex.org/W2078886621","https://openalex.org/W2092507463","https://openalex.org/W2266609660","https://openalex.org/W2424301737","https://openalex.org/W2526593704","https://openalex.org/W3049450389","https://openalex.org/W3049515261"],"related_works":["https://openalex.org/W2102820490","https://openalex.org/W8703292","https://openalex.org/W2512490506","https://openalex.org/W2024640441","https://openalex.org/W2052960342","https://openalex.org/W3208833952","https://openalex.org/W2376856629","https://openalex.org/W3049411419","https://openalex.org/W235103770","https://openalex.org/W2196279192"],"abstract_inverted_index":{"Regulatory":[0],"agencies":[1],"addressing":[2],"human":[3,52],"risk":[4,53],"assessment":[5,54],"of":[6,19,23,43,56,72,99,124,133],"new":[7],"pharmaceuticals,":[8],"pesticides,":[9],"food":[10],"additives,":[11],"cosmetics,":[12],"and":[13,67,92,119,143,152],"other":[14],"chemicals":[15],"currently":[16],"require":[17],"submission":[18],"a":[20],"large":[21],"battery":[22],"in":[24,58,84,90,101],"vivo":[25],"toxicity":[26,78,86],"data":[27],"derived":[28],"from":[29],"tests":[30,87],"utilizing":[31],"laboratory":[32,44],"animals.":[33],"Although":[34],"fairly":[35],"well":[36],"proven":[37],"for":[38,51,75,97,108,113],"evaluating":[39],"toxicity,":[40],"the":[41,120,131,146,153,159],"use":[42,71],"animals":[45],"may":[46,155],"have":[47,88],"limited":[48],"predictive":[49],"values":[50],"because":[55],"differences":[57],"factors,":[59],"such":[60],"as":[61,158],"bioavailability,":[62],"pharmacokinetics,":[63],"metabolism,":[64],"receptor":[65],"sensitivity,":[66],"repair":[68],"mechanisms.":[69],"The":[70],"cell":[73],"cultures":[74],"measuring":[76],"drug":[77],"is":[79,150],"becoming":[80],"increasingly":[81],"acceptable.":[82],"Accordingly,":[83],"vitro":[85],"been":[89],"demand":[91],"numerous":[93],"organizations":[94],"(e.g.,":[95],"Fund":[96],"Replacement":[98],"Animals":[100],"Medical":[102],"Experiments":[103],"[FRAME],":[104],"European":[105],"Research":[106],"Group":[107],"Alternate":[109],"Testing":[110,117],"[ERGAT],":[111],"Center":[112],"Alternatives":[114],"to":[115],"Animal":[116],"[CAAT],":[118],"International":[121],"Multi-Center":[122],"Evaluation":[123],"In":[125],"Vitro":[126],"Cytotoxicity":[127],"[MEIC])":[128],"are":[129],"encouraging":[130],"development":[132],"alternative":[134],"testing":[135],"protocols.":[136],"These":[137],"keywords":[138,154],"were":[139],"added":[140],"by":[141,145],"machine":[142],"not":[144],"authors.":[147],"This":[148],"process":[149],"experimental":[151],"be":[156],"updated":[157],"learning":[160],"algorithm":[161],"improves.":[162]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
