{"id":"https://openalex.org/W2002804393","doi":"https://doi.org/10.1164/ajrccm/147.4.1010","title":"Expression of Interleukin-6 in Association with Rat Lung Reimplantation and Allograft Rejection","display_name":"Expression of Interleukin-6 in Association with Rat Lung Reimplantation and Allograft Rejection","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2002804393","doi":"https://doi.org/10.1164/ajrccm/147.4.1010","mag":"2002804393","pmid":"https://pubmed.ncbi.nlm.nih.gov/8466101"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/147.4.1010","doi":"https://doi.org/10.1164/ajrccm/147.4.1010","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/147.4.1010","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109992311","display_name":"Mark W. Rolfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W. Rolfe","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","Department of Internal Medicine, University of Michigan Medical School, Ann Arbor;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Medical School, Ann Arbor;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004928457","display_name":"Steven L. Kunkel","orcid":"https://orcid.org/0000-0002-5738-6341","observed_orcids":["https://orcid.org/0000-0002-5738-6341"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven L. Kunkel","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022229732","display_name":"Steven R. DeMeester","orcid":"https://orcid.org/0000-0002-5480-8406","observed_orcids":["https://orcid.org/0000-0002-5480-8406"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Demeester","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039587964","display_name":"Donald L. Swiderski","orcid":"https://orcid.org/0000-0001-7572-110X","observed_orcids":["https://orcid.org/0000-0001-7572-110X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L. Swiderski","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113751730","display_name":"P Lincoln","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M. Lincoln","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028606740","display_name":"G. Michael Deeb","orcid":"https://orcid.org/0000-0002-4698-2789","observed_orcids":["https://orcid.org/0000-0002-4698-2789"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Michael Deeb","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","Samuel and Jean Frankel Cardiovascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Samuel and Jean Frankel Cardiovascular Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004985444","display_name":"Robert M. Strieter","orcid":"https://orcid.org/0000-0002-1516-2390","observed_orcids":["https://orcid.org/0000-0002-1516-2390"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert M. Strieter","raw_affiliation_strings":["Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","(University of Michigan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, Pathology, and Surgery, Division of Pulmonary and Critical Care Medicine and the Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"(University of Michigan)","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004985444"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":1.8031,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84571181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"147","issue":"4","first_page":"1010","last_page":"1016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/lung-allograft-rejection","display_name":"lung allograft rejection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7406509518623352},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6943356990814209},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5712742805480957},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5424363017082214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5423896908760071},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5242065191268921},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5075210332870483},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.4821333587169647},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4185985028743744},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41437527537345886},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4024474024772644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39058253169059753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14013394713401794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13259989023208618}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014185","descriptor_name":"Transplantation, Isogeneic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm/147.4.1010","doi":"https://doi.org/10.1164/ajrccm/147.4.1010","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/147.4.1010","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:8466101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8466101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1508946768","display_name":null,"funder_award_id":"HL-02401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2020581369","display_name":"ROLE OF A NOVEL NEUTROPHIL CHEMOTAXIN IN LUNG INJURY","funder_award_id":"5k08hl002401-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2288984632","display_name":"SCOR--OCCUPATIONAL AND IMMUNOLOGICAL LUNG DISEASES","funder_award_id":"5p50hl046487-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2883640743","display_name":null,"funder_award_id":"HL50057","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G670551015","display_name":"TNF AND ICAM-1 AND LUNG ALLOGRAFT REJECTION","funder_award_id":"5r01hl050057-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G753096142","display_name":null,"funder_award_id":"1P50 HL-46487","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W42260490","https://openalex.org/W157721590","https://openalex.org/W1488573278","https://openalex.org/W1501935155","https://openalex.org/W1508898619","https://openalex.org/W1542084647","https://openalex.org/W1622478260","https://openalex.org/W1655974196","https://openalex.org/W1971615288","https://openalex.org/W1987875167","https://openalex.org/W1988356386","https://openalex.org/W1996550094","https://openalex.org/W1997499807","https://openalex.org/W2005699783","https://openalex.org/W2016406628","https://openalex.org/W2019749687","https://openalex.org/W2022881613","https://openalex.org/W2024739367","https://openalex.org/W2026591547","https://openalex.org/W2036452124","https://openalex.org/W2071720748","https://openalex.org/W2071888107","https://openalex.org/W2099883737","https://openalex.org/W2106310310","https://openalex.org/W2113771074","https://openalex.org/W2135392289","https://openalex.org/W2154020009","https://openalex.org/W2162425639","https://openalex.org/W2338978445","https://openalex.org/W2407246661","https://openalex.org/W2409056966","https://openalex.org/W2418636378","https://openalex.org/W4255455886","https://openalex.org/W4290806285"],"related_works":["https://openalex.org/W2169025207","https://openalex.org/W2087651796","https://openalex.org/W2157714072","https://openalex.org/W2040759378","https://openalex.org/W2600733175","https://openalex.org/W2400304526","https://openalex.org/W2087795241","https://openalex.org/W2072852142","https://openalex.org/W2026318169","https://openalex.org/W2017328468"],"abstract_inverted_index":{"Abstract":[0],"Organ":[1],"transplantation":[2,38],"has":[3,28,102],"become":[4],"a":[5,30,40,74,123,170,299],"therapeutic":[6,330],"option":[7],"for":[8,39],"the":[9,17,20,34,82,110,134,137,174,196,207,220,229,250,256,263,269,284,307,313,324],"replacement":[10],"of":[11,19,36,42,54,63,69,77,84,98,112,125,136,148,176,203,209,217,222,238,266,290,302,310,326,334],"malfunctioning":[12],"tissues":[13],"and":[14,56,87,93,106,117,158,194,199,215,233,253,318,328],"organs.":[15,66],"Since":[16],"advent":[18],"first":[21],"combined":[22],"heart-lung":[23],"transplant":[24,49],"in":[25,33,133,173,245,268],"1981,":[26],"there":[27],"been":[29,103],"rapid":[31],"growth":[32],"popularity":[35],"lung":[37,48,99,178,191,210,223,278,293,314,335],"number":[41,124],"end-stage":[43],"pulmonary":[44],"disorders.":[45],"Interestingly,":[46,287],"these":[47],"patients":[50],"experience":[51],"more":[52],"complications":[53],"acute":[55,177],"chronic":[57],"allograft":[58,100,179,192,211,224,258,294,316,336],"rejection":[59,70,101,225,317],"compared":[60],"with":[61,109,150],"recipients":[62,295],"other":[64],"solid":[65],"These":[67,120,304],"episodes":[68],"are":[71],"related":[72,248],"to":[73,91,154,242,249,255,262,297,312],"complex":[75],"series":[76],"events":[78],"that":[79,128,131,165],"depend":[80],"on":[81],"interaction":[83,147],"many":[85],"cells":[86,121],"soluble":[88,126],"mediators":[89],"leading":[90],"cellular":[92,155],"tissue":[94,201],"injury.":[95],"The":[96,146,213,236],"histopathology":[97],"actively":[104],"studied":[105],"is":[107],"associated":[108],"sequestration":[111],"activated":[113],"mononuclear":[114],"phagocytes,":[115],"T":[116],"B":[118],"lymphocytes.":[119],"secrete":[122],"mediators,":[127],"is,":[129],"cytokines,":[130],"participate":[132],"evolution":[135,208],"immune":[138],"response":[139,252],"via":[140],"autocrine,":[141],"paracrine,":[142],"or":[143],"endocrine":[144],"mechanisms.":[145],"cytokines":[149],"their":[151],"targets":[152],"leads":[153],"activation,":[156],"proliferation,":[157],"differentiation.":[159],"In":[160,260],"this":[161,183],"study,":[162],"we":[163,185],"postulated":[164],"interleukin-6":[166],"(IL-6)":[167],"may":[168,319],"have":[169],"central":[171],"role":[172],"pathogenesis":[175,221],"rejection.":[180,212,259,337],"To":[181],"test":[182],"hypothesis,":[184],"employed":[186],"an":[187],"unmodified":[188],"RT1-incompatible":[189],"rat":[190],"model":[193],"assessed":[195],"time":[197],"course":[198],"major":[200],"compartment(s)":[202],"IL-6":[204,218,239,267,272,291,311],"production":[205,216,273,309],"during":[206,219,283,315,332],"expression":[214,237,265],"was":[226,240,280],"measured":[227,274],"at":[228],"whole-animal,":[230],"organ,":[231],"cellular,":[232],"molecular":[234],"levels.":[235],"found":[241],"be":[243],"bimodal":[244,264,300],"character,":[246],"initially":[247],"reimplantation":[251,285],"finally":[254],"maximal":[257,281],"contrast":[261],"allogeneic":[270],"transplant,":[271],"from":[275,292],"syngeneic":[276],"control":[277],"isografts":[279],"only":[282],"period.":[286],"plasma":[288],"levels":[289],"failed":[296],"display":[298],"pattern":[301],"expression.":[303],"findings":[305],"support":[306],"compartmentalized":[308],"provide":[320],"interesting":[321],"insight":[322],"into":[323],"use":[325],"novel":[327],"specific":[329],"interventions":[331],"periods":[333]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
