{"id":"https://openalex.org/W2002803484","doi":"https://doi.org/10.1016/j.lab.2005.01.007","title":"Treatment of Wilson\u2019s disease with zinc from the time of diagnosis in pediatric patients: A single-hospital, 10-year follow-up study","display_name":"Treatment of Wilson\u2019s disease with zinc from the time of diagnosis in pediatric patients: A single-hospital, 10-year follow-up study","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2002803484","doi":"https://doi.org/10.1016/j.lab.2005.01.007","mag":"2002803484","pmid":"https://pubmed.ncbi.nlm.nih.gov/15871305"},"language":"en","primary_location":{"id":"doi:10.1016/j.lab.2005.01.007","doi":"https://doi.org/10.1016/j.lab.2005.01.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lab.2005.01.007","pdf_url":null,"source":{"id":"https://openalex.org/S26537864","display_name":"Journal of Laboratory and Clinical Medicine","issn_l":"0022-2143","issn":["0022-2143","1532-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory and Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052616750","display_name":"Matilde Marcellini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matilde Marcellini","raw_affiliation_strings":["Department of Liver Disease, Children's Hospital Bambino Ges\u00f9, P.za S. Onofrio, 4, 00165 Rome","\u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Disease, Children's Hospital Bambino Ges\u00f9, P.za S. Onofrio, 4, 00165 Rome","institution_ids":["https://openalex.org/I4210123352"]},{"raw_affiliation_string":"\u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019177884","display_name":"Vincenzo Maria Di Ciommo","orcid":"https://orcid.org/0000-0003-4964-5224","observed_orcids":["https://orcid.org/0000-0003-4964-5224"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Di Ciommo","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009721795","display_name":"Francesco Callea","orcid":"https://orcid.org/0000-0002-7554-1376","observed_orcids":["https://orcid.org/0000-0002-7554-1376"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Callea","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044116082","display_name":"Rita De Vito","orcid":"https://orcid.org/0000-0002-7450-8398","observed_orcids":["https://orcid.org/0000-0002-7450-8398"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Devito","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060526299","display_name":"Donatella Comparcola","orcid":"https://orcid.org/0000-0001-8019-2388","observed_orcids":["https://orcid.org/0000-0001-8019-2388"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Comparcola","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086103785","display_name":"Maria Rita Sartorelli","orcid":"https://orcid.org/0000-0002-3725-1677","observed_orcids":["https://orcid.org/0000-0002-3725-1677"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Rita Sartorelli","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesco Carelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Carelli","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075835057","display_name":"Val\u00e9rio Nobili","orcid":"https://orcid.org/0000-0002-4570-3979","observed_orcids":["https://orcid.org/0000-0002-4570-3979"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Valerio Nobili","raw_affiliation_strings":["Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075835057"],"corresponding_institution_ids":["https://openalex.org/I4210123352"],"apc_list":null,"apc_paid":null,"fwci":4.5492,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.93916904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"145","issue":"3","first_page":"139","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilson-s-disease","display_name":"Wilson's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/zinc-therapy","display_name":"zinc therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/zinc-sulfate","display_name":"zinc sulfate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6740000247955322},{"id":"https://openalex.org/keywords/presymptomatic-treatment","display_name":"presymptomatic treatment","score":0.8080000281333923},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/copper-metabolism","display_name":"copper metabolism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.6959999799728394},{"id":"https://openalex.org/keywords/kayser-fleischer-rings","display_name":"Kayser-Fleischer rings","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/urinary-copper-excretion","display_name":"urinary copper excretion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.8339999914169312},{"id":"https://openalex.org/keywords/growth","display_name":"growth","score":0.4519999921321869},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.6610000133514404},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.49900001287460327},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7423242926597595},{"id":"https://openalex.org/C2776231509","wikidata":"https://www.wikidata.org/wiki/Q117121","display_name":"Wilson's disease","level":3,"score":0.7043992280960083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6867936253547668},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6131691336631775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.585236132144928},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5697965621948242},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5376319885253906},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5281108617782593},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.43890848755836487},{"id":"https://openalex.org/C2991729501","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper metabolism","level":3,"score":0.4321909546852112},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.42895954847335815},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30603140592575073},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.2065020203590393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15442579984664917},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019287","descriptor_name":"Zinc Sulfate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lab.2005.01.007","doi":"https://doi.org/10.1016/j.lab.2005.01.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lab.2005.01.007","pdf_url":null,"source":{"id":"https://openalex.org/S26537864","display_name":"Journal of Laboratory and Clinical Medicine","issn_l":"0022-2143","issn":["0022-2143","1532-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory and Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:15871305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15871305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1583438511","https://openalex.org/W1965480412","https://openalex.org/W1972011545","https://openalex.org/W1978194741","https://openalex.org/W1979500357","https://openalex.org/W2018239192","https://openalex.org/W2022970217","https://openalex.org/W2024880904","https://openalex.org/W2033421072","https://openalex.org/W2038987046","https://openalex.org/W2041890833","https://openalex.org/W2067965621","https://openalex.org/W2073832531","https://openalex.org/W2074605066","https://openalex.org/W2111658457","https://openalex.org/W2112544498","https://openalex.org/W2115956200","https://openalex.org/W2125095197","https://openalex.org/W2125848406","https://openalex.org/W2136220561","https://openalex.org/W2143190548","https://openalex.org/W2248606527","https://openalex.org/W2405339729","https://openalex.org/W2415454775","https://openalex.org/W4212883074","https://openalex.org/W4242082702","https://openalex.org/W4254294059"],"related_works":["https://openalex.org/W2073302179","https://openalex.org/W2248606527","https://openalex.org/W2964326123","https://openalex.org/W2427421716","https://openalex.org/W2415454775","https://openalex.org/W2101761561","https://openalex.org/W4254822018","https://openalex.org/W3134318877","https://openalex.org/W252224936","https://openalex.org/W2042974688"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}