{"id":"https://openalex.org/W2002803271","doi":"https://doi.org/10.1021/bi0029090","title":"Conformationally Specific Misfolding of an Integral Membrane Protein","display_name":"Conformationally Specific Misfolding of an Integral Membrane Protein","publication_year":2001,"publication_date":"2001-04-05","ids":{"openalex":"https://openalex.org/W2002803271","doi":"https://doi.org/10.1021/bi0029090","mag":"2002803271","pmid":"https://pubmed.ncbi.nlm.nih.gov/11318632"},"language":"en","primary_location":{"id":"doi:10.1021/bi0029090","doi":"https://doi.org/10.1021/bi0029090","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0029090","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070735075","display_name":"Kirill Oxenoid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirill Oxenoid","raw_affiliation_strings":["Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063724891","display_name":"Frank D. S\u00f6nnichsen","orcid":"https://orcid.org/0000-0002-4539-3755","observed_orcids":["https://orcid.org/0000-0002-4539-3755"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank D. S\u00f6nnichsen","raw_affiliation_strings":["Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970","Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, 44106-4970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, 44106-4970","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007437458","display_name":"Charles R. Sanders","orcid":"https://orcid.org/0000-0003-2046-2862","observed_orcids":["https://orcid.org/0000-0003-2046-2862"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles R. Sanders","raw_affiliation_strings":["Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970","Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, 44106-4970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, 44106-4970","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1561,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75630916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"17","first_page":"5111","last_page":"5118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diacylglycerol-kinase","display_name":"diacylglycerol kinase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/homotrimer","display_name":"homotrimer","score":0.5799999833106995},{"id":"https://openalex.org/keywords/transmembrane-proteins","display_name":"transmembrane proteins","score":0.6620000004768372},{"id":"https://openalex.org/keywords/detergent-micelles","display_name":"detergent micelles","score":0.796999990940094},{"id":"https://openalex.org/keywords/chemical-shift-dispersion","display_name":"chemical shift dispersion","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.7799999713897705},{"id":"https://openalex.org/keywords/secondary-structure","display_name":"secondary structure","score":0.6349999904632568},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7455129027366638},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5316591262817383},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5141851902008057},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4836219847202301},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.48277392983436584},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4698340594768524},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46910959482192993},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4224250614643097},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4191700220108032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32625654339790344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11237090826034546},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019852","descriptor_name":"Diacylglycerol Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi0029090","doi":"https://doi.org/10.1021/bi0029090","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0029090","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11318632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11318632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1179255374","display_name":"APPLYING SOLUTION NMR TO LARGER MEMBRANE PROTEINS","funder_award_id":"1r21gm059071-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1734690950","display_name":null,"funder_award_id":"R21 GM59071","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1800733478","display_name":null,"funder_award_id":"R01GM47485","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3290140266","display_name":"Diacylglycerol Kinase: Structure, Folding, and Mechanism","funder_award_id":"R01GM047485","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W164666323","https://openalex.org/W2003794281","https://openalex.org/W2006925909","https://openalex.org/W2019323543","https://openalex.org/W2034120336","https://openalex.org/W2034456418","https://openalex.org/W2045010160","https://openalex.org/W2050510818","https://openalex.org/W2052880253","https://openalex.org/W2155147384","https://openalex.org/W4230554171"],"related_works":["https://openalex.org/W2087964729","https://openalex.org/W2087173221","https://openalex.org/W2037848731","https://openalex.org/W2002326153","https://openalex.org/W169092238","https://openalex.org/W2050510818","https://openalex.org/W2069395833","https://openalex.org/W4392877840","https://openalex.org/W35911669","https://openalex.org/W2094868556"],"abstract_inverted_index":{"Membrane":[0],"protein":[1,37],"misfolding":[2,24,233],"is":[3,12],"related":[4],"to":[5,159,225],"the":[6,67,91,115,133,140,160,175,196,210,215,227],"etiology":[7],"of":[8,25,29,43,69,77,97,112,127,168,230,234],"many":[9],"diseases,":[10],"but":[11,85],"poorly":[13],"understood,":[14],"particularly":[15],"from":[16,114],"a":[17,26,33,47,70,100,108,119,150,165],"structural":[18,172,203],"standpoint.":[19],"This":[20,222],"study":[21],"focuses":[22],"upon":[23],"mutant":[27],"form":[28,219],"diacylglycerol":[30],"kinase":[31],"(s-DAGK),":[32],"40":[34],"kDa":[35,102],"homotrimeric":[36],"having":[38],"nine":[39],"transmembrane":[40],"segments.":[41],"Preparations":[42],"s-DAGK":[44,78,98,148,194],"sometimes":[45],"contain":[46],"kinetically":[48,216],"trapped":[49,217],"misfolded":[50,116,121,193,218],"population,":[51],"as":[52,99],"evidenced":[53],"by":[54,66,190],"lower-than-expected":[55],"enzyme":[56,137,213],"activity":[57,138],"(with":[58],"no":[59],"accompanying":[60],"change":[61],"in":[62,73,136,153,170,180],"substrate":[63],"K(m))":[64],"and":[65,185,192,214],"appearance":[68],"second":[71],"band":[72],"electrophoresis":[74],"gels.":[75],"Misfolding":[76],"may":[79],"take":[80],"place":[81],"during":[82],"cellular":[83],"overexpression,":[84],"can":[86],"also":[87],"be":[88],"reproduced":[89],"using":[90],"purified":[92],"enzyme.":[93],"TROSY":[94],"NMR":[95,181],"spectra":[96],"100":[101],"complex":[103],"with":[104,132,164],"detergent":[105],"micelles":[106],"exhibit":[107],"single":[109,120],"additional":[110],"set":[111],"resonances":[113,130],"form,":[117],"indicating":[118],"conformational":[122],"state.":[123],"The":[124],"relative":[125],"intensities":[126],"these":[128],"extra":[129],"correlate":[131],"percent":[134],"reduction":[135],"below":[139],"maximum":[141],"observed":[142],"for":[143],"fully":[144],"folded":[145,161,191,212],"s-DAGK.":[146],"Misfolded":[147],"exhibits":[149],"modest":[151],"difference":[152],"its":[154],"far-UV":[155],"CD":[156],"spectrum":[157],"compared":[158],"enzyme,":[162],"consistent":[163],"small":[166],"degree":[167],"variance":[169],"secondary":[171],"content":[173],"between":[174],"two":[176],"forms.":[177],"However,":[178],"differences":[179],"chemical":[182],"shift":[183],"dispersion":[184],"temperature-dependent":[186],"line":[187],"widths":[188],"exhibited":[189],"support":[195],"notion":[197],"that":[198,208],"they":[199],"represent":[200,226],"very":[201],"different":[202],"states.":[204],"Cross-linking":[205],"experiments":[206],"indicate":[207],"both":[209],"correctly":[211],"are":[220],"homotrimers.":[221],"work":[223],"appears":[224],"first":[228],"documentation":[229],"conformationally":[231],"specific":[232],"an":[235],"integral":[236],"membrane":[237],"protein.":[238]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
