{"id":"https://openalex.org/W2002782735","doi":"https://doi.org/10.1136/bjo.73.1.42","title":"Ocular toxicity of desferrioxamine--an example of copper promoted auto-oxidative damage?","display_name":"Ocular toxicity of desferrioxamine--an example of copper promoted auto-oxidative damage?","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2002782735","doi":"https://doi.org/10.1136/bjo.73.1.42","mag":"2002782735","pmid":"https://pubmed.ncbi.nlm.nih.gov/2784062","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1041641"},"language":"en","primary_location":{"id":"doi:10.1136/bjo.73.1.42","doi":"https://doi.org/10.1136/bjo.73.1.42","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.73.1.42","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/73/1/42.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjo.bmj.com/content/bjophthalmol/73/1/42.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054069514","display_name":"Hardev Pall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H Pall","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109435958","display_name":"D R Blake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D R Blake","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042238470","display_name":"Paul Graham Winyard","orcid":"https://orcid.org/0000-0002-9613-1202","observed_orcids":["https://orcid.org/0000-0002-9613-1202"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Winyard","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109937924","display_name":"J. Lunec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Lunec","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101485760","display_name":"Adrian C. Williams","orcid":"https://orcid.org/0000-0002-9306-944X","observed_orcids":["https://orcid.org/0000-0002-9306-944X"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Williams","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039370541","display_name":"Peter A. Good","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P A Good","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049832567","display_name":"E E Kritzinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E E Kritzinger","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040864308","display_name":"Allen L. Cornish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Cornish","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020843793","display_name":"Robert C. Hider","orcid":"https://orcid.org/0000-0003-1330-5797","observed_orcids":["https://orcid.org/0000-0003-1330-5797"]},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I4210117485","display_name":"Birmingham and Midland Eye Centre","ror":"https://ror.org/01n70p029","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799630439","https://openalex.org/I4210117485"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R C Hider","raw_affiliation_strings":["Department of Neurology, Medical School, University of Birmingham","3Department of Chemistry, University of Essex, Colchester C04 3SQ","From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical School, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"3Department of Chemistry, University of Essex, Colchester C04 3SQ","institution_ids":["https://openalex.org/I110002522"]},{"raw_affiliation_string":"From the 'Departments ofNeurology and Rheumatology, the Medical School, University of Birmingham, Birmingham B15 2TJ; 2Birmingham and","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Midland Eye Hospital, Church Street, Birmingham B3 2NS; and the","institution_ids":["https://openalex.org/I4210117485"]},{"raw_affiliation_string":"Neurology Department, Addenbrooke's Hospital, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I4210156194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0749,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.95035461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"1","first_page":"42","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.40700000524520874},{"id":"https://openalex.org/keywords/rheumatoid-disease","display_name":"rheumatoid disease","score":0.8489999771118164},{"id":"https://openalex.org/keywords/methyldopa","display_name":"methyldopa","score":0.8270000219345093},{"id":"https://openalex.org/keywords/electrooculogram","display_name":"electrooculogram","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vision-loss","display_name":"vision loss","score":0.5960000157356262},{"id":"https://openalex.org/keywords/phenanthroline","display_name":"phenanthroline","score":0.703000009059906},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.796999990940094},{"id":"https://openalex.org/keywords/drug-induced-retinal-damage","display_name":"drug-induced retinal damage","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.7722023725509644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7378621101379395},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7083433866500854},{"id":"https://openalex.org/C2778404011","wikidata":"https://www.wikidata.org/wiki/Q5168803","display_name":"Copper toxicity","level":3,"score":0.6062061786651611},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5960198640823364},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5043646097183228},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.431460440158844},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4091036915779114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3147065043449402},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09058201313018799},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004585","descriptor_name":"Electrooculography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008750","descriptor_name":"Methyldopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1136/bjo.73.1.42","doi":"https://doi.org/10.1136/bjo.73.1.42","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.73.1.42","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/73/1/42.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1041641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1041641","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1041641/pdf/brjopthal00593-0053.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Ophthalmol","raw_type":"Text"},{"id":"pmid:2784062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2784062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Case Reports"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.918.3722","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.918.3722","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bjo.bmj.com/content/73/1/42.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:bjophthalmol:73/1/42","doi":null,"is_oa":false,"landing_page_url":"http://bjo.bmj.com/cgi/content/short/73/1/42","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"mag:2551115825","doi":null,"is_oa":false,"landing_page_url":"https://bjo.bmj.com/content/73/1/42.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1136/bjo.73.1.42","doi":"https://doi.org/10.1136/bjo.73.1.42","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.73.1.42","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/73/1/42.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002782735.pdf","grobid_xml":"https://content.openalex.org/works/W2002782735.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W23595113","https://openalex.org/W58328632","https://openalex.org/W97551392","https://openalex.org/W142717435","https://openalex.org/W183973565","https://openalex.org/W187566210","https://openalex.org/W189585810","https://openalex.org/W1527893881","https://openalex.org/W1602331755","https://openalex.org/W1670573333","https://openalex.org/W1816728254","https://openalex.org/W1973361878","https://openalex.org/W1974589160","https://openalex.org/W1987750048","https://openalex.org/W2015439976","https://openalex.org/W2016325045","https://openalex.org/W2018388019","https://openalex.org/W2030922784","https://openalex.org/W2031229678","https://openalex.org/W2033788381","https://openalex.org/W2040432339","https://openalex.org/W2051260674","https://openalex.org/W2087075920","https://openalex.org/W2408824935","https://openalex.org/W2461446764","https://openalex.org/W6825895537"],"related_works":["https://openalex.org/W7097160654","https://openalex.org/W23595113","https://openalex.org/W7097880861","https://openalex.org/W2071001076","https://openalex.org/W1969993658","https://openalex.org/W1965601064","https://openalex.org/W2093967697","https://openalex.org/W1990752141","https://openalex.org/W2399701434","https://openalex.org/W920318936"],"abstract_inverted_index":{"Three":[0],"patients":[1,31,45,117,161],"with":[2,32,62,155],"rheumatoid":[3,160],"disease":[4],"were":[5],"given":[6],"the":[7,43,72,76,93,96,156,183],"'iron":[8],"chelating'":[9],"drug":[10,22],"desferrioxamine":[11],"(DFX),":[12],"which":[13],"also":[14,52],"has":[15],"an":[16,63,84],"appreciable":[17],"affinity":[18],"for":[19],"copper.":[20,90],"The":[21],"was":[23,109,127,147],"injected":[24],"cautiously,":[25],"in":[26,30,86,159,167,181],"lower":[27],"doses":[28],"than":[29],"thalassaemia,":[33],"and":[34,134,173],"intramuscularly":[35],"to":[36,129,135],"evaluate":[37],"its":[38],"anti-inflammatory":[39],"effects.":[40],"Two":[41],"of":[42,71,75,80,92,95,169,178,186],"three":[44,116],"developed":[46,55],"ocular":[47,107,184],"abnormalities.":[48],"One":[49],"patient,":[50,98],"who":[51,99],"received":[53],"methyldopa,":[54],"severe":[56],"but":[57],"reversible":[58,69],"visual":[59],"failure":[60],"associated":[61],"abnormal":[64],"electro-oculogram":[65],"(EOG);":[66],"another":[67],"showed":[68,83],"depression":[70],"EOG.":[73],"Analysis":[74,91],"cerebrospinal":[77],"fluid":[78],"(CSF)":[79],"this":[81,175],"patient":[82],"increase":[85],"phenanthroline":[87],"detectable":[88],"(non-caeruloplasmin-bound)":[89],"CSF":[94],"third":[97],"did":[100],"not":[101],"develop":[102],"any":[103],"clinical":[104],"or":[105],"electrophysiological":[106],"abnormalities,":[108],"normal.":[110],"Haematological":[111],"assessments":[112],"indicated":[113],"that":[114,146,158,174],"all":[115],"probably":[118],"had":[119],"reduced":[120],"iron":[121,163],"stores.":[122],"With":[123],"in-vitro":[124],"systems":[125],"DFX":[126,172],"shown":[128],"mobilise":[130],"copper":[131,137,170],"from":[132],"albumin":[133],"facilitate":[136],"movement":[138],"across":[139],"a":[140,144],"cell":[141],"membrane":[142],"model,":[143],"property":[145],"enhanced":[148],"by":[149,171],"methyldopa.":[150],"Our":[151],"observations":[152],"are":[153],"consistent":[154],"concept":[157],"low":[162],"stores":[164],"may":[165,176],"result":[166],"binding":[168],"be":[177],"central":[179],"importance":[180],"causing":[182],"toxicity":[185],"DFX.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}