{"id":"https://openalex.org/W2002767652","doi":"https://doi.org/10.1039/c3ra21668c","title":"Creation and control of defined protein patterns on glass: alkyl chain length controls stability","display_name":"Creation and control of defined protein patterns on glass: alkyl chain length controls stability","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2002767652","doi":"https://doi.org/10.1039/c3ra21668c","mag":"2002767652"},"language":"en","primary_location":{"id":"doi:10.1039/c3ra21668c","doi":"https://doi.org/10.1039/c3ra21668c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3ra21668c","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067572871","display_name":"Clifford A. Schlecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford A. Schlecht","raw_affiliation_strings":["Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dawn M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn M. Johnson","raw_affiliation_strings":["Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043048419","display_name":"Joshua A. Maurer","orcid":"https://orcid.org/0000-0002-6663-0721","observed_orcids":["https://orcid.org/0000-0002-6663-0721"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua A. Maurer","raw_affiliation_strings":["Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis, St. Louis, MO, 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry and Center for Materials Innovation, Washington University in St. Louis,St. Louis,USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043048419"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0856102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"23","first_page":"8826","last_page":"8826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12012","display_name":"Diatoms and Algae Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-patterning","display_name":"protein patterning","score":0.722000002861023},{"id":"https://openalex.org/keywords/glass-surfaces","display_name":"glass surfaces","score":0.6060000061988831},{"id":"https://openalex.org/keywords/self-assembled-monolayers","display_name":"self-assembled monolayers","score":0.984000027179718},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.996999979019165},{"id":"https://openalex.org/keywords/monolayer-stability","display_name":"monolayer stability","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-resistance","display_name":"protein adsorption resistance","score":0.8840000033378601},{"id":"https://openalex.org/keywords/surface-functionalization","display_name":"surface functionalization","score":0.7200000286102295},{"id":"https://openalex.org/keywords/oxide-substrates","display_name":"oxide substrates","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.8878857493400574},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.8398861885070801},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.758073091506958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5336063504219055},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.49884963035583496},{"id":"https://openalex.org/C2781327020","wikidata":"https://www.wikidata.org/wiki/Q41581","display_name":"Alkane","level":3,"score":0.47895553708076477},{"id":"https://openalex.org/C131649739","wikidata":"https://www.wikidata.org/wiki/Q1121115","display_name":"Self-assembled monolayer","level":3,"score":0.4546348452568054},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.44702082872390747},{"id":"https://openalex.org/C2779248272","wikidata":"https://www.wikidata.org/wiki/Q419041","display_name":"Trichlorosilane","level":3,"score":0.43986812233924866},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4228115975856781},{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.41820722818374634},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3924614191055298},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.37760499119758606},{"id":"https://openalex.org/C544956773","wikidata":"https://www.wikidata.org/wiki/Q670","display_name":"Silicon","level":2,"score":0.3384733200073242},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23913222551345825},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.2207929790019989},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10590988397598267},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/c3ra21668c","doi":"https://doi.org/10.1039/c3ra21668c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3ra21668c","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1480838520","https://openalex.org/W1967334144","https://openalex.org/W1967598238","https://openalex.org/W1969493961","https://openalex.org/W1972091231","https://openalex.org/W1972559288","https://openalex.org/W1981096607","https://openalex.org/W1982421904","https://openalex.org/W1995353935","https://openalex.org/W1995829317","https://openalex.org/W2010462640","https://openalex.org/W2010692560","https://openalex.org/W2015295639","https://openalex.org/W2019366993","https://openalex.org/W2021698885","https://openalex.org/W2022265330","https://openalex.org/W2023022008","https://openalex.org/W2032594857","https://openalex.org/W2035736699","https://openalex.org/W2056648038","https://openalex.org/W2057026947","https://openalex.org/W2060548005","https://openalex.org/W2060831508","https://openalex.org/W2066103357","https://openalex.org/W2073772623","https://openalex.org/W2074374586","https://openalex.org/W2075561946","https://openalex.org/W2081710345","https://openalex.org/W2081942468","https://openalex.org/W2084323072","https://openalex.org/W2087706895","https://openalex.org/W2088556077","https://openalex.org/W2092093999","https://openalex.org/W2092167898","https://openalex.org/W2095582071","https://openalex.org/W2108861052","https://openalex.org/W2118146438","https://openalex.org/W2126288271","https://openalex.org/W2139667671","https://openalex.org/W2185386454"],"related_works":["https://openalex.org/W378497689","https://openalex.org/W2010692560","https://openalex.org/W2113874056","https://openalex.org/W7047368269","https://openalex.org/W2998109377","https://openalex.org/W2042771950","https://openalex.org/W1991013335","https://openalex.org/W8509391","https://openalex.org/W2109794183","https://openalex.org/W2001674371"],"abstract_inverted_index":{"Here":[0],"we":[1,99],"present":[2],"a":[3,49,58,91,124,136,142],"method":[4,137],"for":[5,88,120,138],"the":[6,29,41,62,66,73,129,139],"production":[7],"of":[8,68,141,145],"defined":[9],"protein":[10,83],"patterns":[11],"on":[12],"glass":[13],"using":[14,107,117],"trimethoxysilane-terminated":[15,96],"self-assembled":[16],"monolayer":[17,36],"(SAM)":[18],"chemistry.":[19],"The":[20,94],"surfaces":[21],"were":[22],"characterized":[23],"by":[24],"infrared":[25],"spectroscopy":[26],"to":[27,47,81],"determine":[28],"relationship":[30],"between":[31],"alkyl":[32,43],"chain":[33,44,70,77],"length":[34,45,71,78],"and":[35,112,128],"order":[37],"and,":[38],"in":[39],"turn,":[40],"critical":[42],"required":[46],"produce":[48],"tightly":[50],"packed":[51],"SAM.":[52],"Protein":[53],"resistance":[54],"studies,":[55],"which":[56,151],"incorporated":[57],"glycol":[59],"region":[60],"into":[61],"monomer,":[63],"further":[64],"highlighted":[65],"importance":[67],"alkane":[69],"within":[72],"monolayer,":[74],"as":[75],"increased":[76],"was":[79],"necessary":[80],"generate":[82],"resistant":[84],"regions":[85],"that":[86,98],"persisted":[87],"more":[89],"than":[90],"few":[92],"days.":[93],"long-chain":[95],"monomers":[97,127],"have":[100],"developed":[101,119],"are":[102],"stable,":[103],"can":[104,113],"be":[105,114],"purified":[106],"standard":[108],"silicon":[109],"gel":[110],"chromatography,":[111],"easily":[115],"patterned":[116],"methods":[118],"other":[121],"SAMs.":[122],"As":[123],"result,":[125],"these":[126],"resulting":[130],"monolayers":[131],"produced":[132],"from":[133],"them":[134],"provide":[135],"functionalization":[140],"wide":[143],"variety":[144],"oxide":[146],"substrates,":[147],"including":[148],"ordinary":[149],"glass,":[150],"has":[152],"enormous":[153],"advantages":[154],"over":[155],"previous":[156],"glycol-terminated":[157],"trichlorosilane":[158],"monomers.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}