{"id":"https://openalex.org/W2002734656","doi":"https://doi.org/10.1093/nar/22.24.5399","title":"Alternate pathways for processing in the internal transcribed spacer 1 in pre-rRNA of Saccharomyces cerevisiae","display_name":"Alternate pathways for processing in the internal transcribed spacer 1 in pre-rRNA of Saccharomyces cerevisiae","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2002734656","doi":"https://doi.org/10.1093/nar/22.24.5399","mag":"2002734656","pmid":"https://pubmed.ncbi.nlm.nih.gov/7816631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/332089"},"language":"en","primary_location":{"id":"doi:10.1093/nar/22.24.5399","doi":"https://doi.org/10.1093/nar/22.24.5399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/22.24.5399","pdf_url":"https://academic.oup.com/nar/article-pdf/22/24/5399/3530589/22-24-5399.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/22/24/5399/3530589/22-24-5399.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087363205","display_name":"Lasse Lindahl","orcid":"https://orcid.org/0000-0001-8418-7885","observed_orcids":["https://orcid.org/0000-0001-8418-7885"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lasse Lindahl","raw_affiliation_strings":["Department of Biology, University of Rochester, NY 14627","Department of Biology, University of RochesterRochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester, NY 14627","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Biology, University of RochesterRochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073471291","display_name":"Richard H. Archer","orcid":"https://orcid.org/0000-0002-1562-3185","observed_orcids":["https://orcid.org/0000-0002-1562-3185"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H. Archer","raw_affiliation_strings":["Department of Biology, University of Rochester Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046316721","display_name":"Janice M. Zengel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice M. Zengel","raw_affiliation_strings":["Department of Biology, University of Rochester Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087363205"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":1.2003,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77669711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"22","issue":"24","first_page":"5399","last_page":"5407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.48339998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.48339998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.10890000313520432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internal-transcribed-spacer-1","display_name":"internal transcribed spacer 1","score":0.953000009059906},{"id":"https://openalex.org/keywords/pre-rrna-processing","display_name":"pre-rRNA processing","score":0.9539999961853027},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cleavage-site-mapping","display_name":"cleavage site mapping","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8559545278549194},{"id":"https://openalex.org/C155794727","wikidata":"https://www.wikidata.org/wiki/Q2306414","display_name":"Internal transcribed spacer","level":4,"score":0.832402229309082},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.7056758999824524},{"id":"https://openalex.org/C116029586","wikidata":"https://www.wikidata.org/wiki/Q4675666","display_name":"Spacer DNA","level":5,"score":0.5531917810440063},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5479223728179932},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.5165516138076782},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48923587799072266},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4658798575401306},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4584813117980957},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.4090460538864136},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.39582639932632446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3115782141685486},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/22.24.5399","doi":"https://doi.org/10.1093/nar/22.24.5399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/22.24.5399","pdf_url":"https://academic.oup.com/nar/article-pdf/22/24/5399/3530589/22-24-5399.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:463912","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC307158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:332089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/332089","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:7816631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7816631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:mdsoar.org:11603/14031","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11603/14031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402556","display_name":"Maryland Shared Open Access Repository (USMAI Consortium)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.13016/m2nu8r-vb63","doi":"https://doi.org/10.13016/m2nu8r-vb63","is_oa":true,"landing_page_url":"https://doi.org/10.13016/m2nu8r-vb63","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/nar/22.24.5399","doi":"https://doi.org/10.1093/nar/22.24.5399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/22.24.5399","pdf_url":"https://academic.oup.com/nar/article-pdf/22/24/5399/3530589/22-24-5399.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002734656.pdf","grobid_xml":"https://content.openalex.org/works/W2002734656.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W20619123","https://openalex.org/W109701900","https://openalex.org/W1515283239","https://openalex.org/W1559808711","https://openalex.org/W1584699951","https://openalex.org/W1585970141","https://openalex.org/W1679428278","https://openalex.org/W1846812271","https://openalex.org/W1966929898","https://openalex.org/W1967390330","https://openalex.org/W1984491679","https://openalex.org/W1996851109","https://openalex.org/W1997680593","https://openalex.org/W2003210932","https://openalex.org/W2018430759","https://openalex.org/W2023018666","https://openalex.org/W2028007077","https://openalex.org/W2058401582","https://openalex.org/W2066200564","https://openalex.org/W2073322721","https://openalex.org/W2076821933","https://openalex.org/W2115839673","https://openalex.org/W2117008060","https://openalex.org/W2140224280","https://openalex.org/W2144535541","https://openalex.org/W2166952949","https://openalex.org/W2323778292","https://openalex.org/W6633861719"],"related_works":["https://openalex.org/W2076821933","https://openalex.org/W2993518094","https://openalex.org/W1929480046","https://openalex.org/W2153821277","https://openalex.org/W1585970141","https://openalex.org/W1967887348","https://openalex.org/W6980607209","https://openalex.org/W2421303168","https://openalex.org/W2169618180","https://openalex.org/W2131436482"],"abstract_inverted_index":{"We":[0],"have":[1,51,101],"extended":[2],"the":[3,54,59,66,72,76,82,85,95,110,136,144,149,161,168,171],"system":[4,49],"of":[5,19,65,84,109,148,160,170],"Nogi":[6],"et":[7],"al.":[8],"(Proc.":[9],"Natl.":[10],"Acad.":[11],"Sci.":[12],"USA":[13],"88,":[14],"1991,":[15],"3962-3966)":[16],"for":[17,92,129,166],"transcription":[18,41],"rRNA":[20,40,87],"from":[21],"an":[22],"RNA":[23,31],"polymerase":[24,32],"II":[25],"promoter":[26],"in":[27,58,123,135,152],"strains":[28,36],"lacking":[29],"functional":[30],"I.":[33],"In":[34],"our":[35],"two":[37,96],"differentially":[38],"marked":[39],"units":[42],"can":[43],"be":[44],"expressed":[45],"alternately.":[46],"Using":[47],"this":[48],"we":[50,100],"shown":[52],"that":[53,89,126,157],"A2":[55,77,105,137,145,162],"processing":[56,74,119,131,142],"site":[57,78,120,163],"internal":[60],"transcribed":[61],"spacer":[62],"1":[63],"(ITS1)":[64],"pre-rRNA":[67],"is":[68,106],"dispensable.":[69],"According":[70],"to":[71,80],"accepted":[73],"scheme,":[75],"serves":[79],"separate":[81],"parts":[83],"primary":[86],"transcript":[88],"are":[90,164],"destined":[91],"incorporation":[93],"into":[94],"ribosomal":[97],"subunits.":[98],"However,":[99],"found":[102],"that,":[103],"when":[104],"impaired,":[107],"separation":[108],"small":[111],"and":[112],"large":[113],"subunit":[114],"rRNAs":[115],"occurs":[116],"at":[117,143],"a":[118],"further":[121],"downstream":[122,159],"ITS1,":[124],"indicating":[125],"alternate":[127],"pathways":[128],"ITS1":[130],"exist.":[132],"Short":[133],"deletions":[134],"region":[138],"still":[139],"allow":[140],"residual":[141],"site.":[146],"Mapping":[147],"cleavage":[150],"sites":[151],"such":[153],"deletion":[154],"transcripts":[155],"suggests":[156],"sequences":[158],"used":[165],"determining":[167],"position":[169],"cleavage.":[172]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
