{"id":"https://openalex.org/W2002711073","doi":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","title":"Metrifonate: A Cholinesterase Inhibitor for Alzheimer's Disease Therapy","display_name":"Metrifonate: A Cholinesterase Inhibitor for Alzheimer's Disease Therapy","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2002711073","doi":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","mag":"2002711073"},"language":"en","primary_location":{"id":"doi:10.1111/j.1527-3458.1999.tb00083.x","doi":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","pdf_url":null,"source":{"id":"https://openalex.org/S165828461","display_name":"CNS Drug Reviews","issn_l":"1080-563X","issn":["1080-563X","1527-3458"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059020389","display_name":"Lon S. S. Schneider","orcid":"https://orcid.org/0000-0002-4636-6150","observed_orcids":["https://orcid.org/0000-0002-4636-6150"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lon S. Schneider","raw_affiliation_strings":["Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, California, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104059981","display_name":"Ezio Giacobini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ezio Giacobini","raw_affiliation_strings":["Department of Geriatrics, University Hospitals of Geriatrics, Medical School of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, University Hospitals of Geriatrics, Medical School of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059020389"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":1.6702,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.84228972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"1","first_page":"13","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichlorfon","display_name":"trichlorfon","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.953000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antiparasitic-drugs","display_name":"antiparasitic drugs","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7609999775886536},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.8208329677581787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6120418310165405},{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.5754575133323669},{"id":"https://openalex.org/C2779046751","wikidata":"https://www.wikidata.org/wiki/Q421076","display_name":"Tacrine","level":4,"score":0.5354808568954468},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.5149236917495728},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5108177661895752},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4830487370491028},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43963223695755005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43148335814476013},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.36759722232818604},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2913209795951843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26717114448547363},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.22748929262161255},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.2233421504497528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13472840189933777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06929710507392883},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06804946064949036}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1527-3458.1999.tb00083.x","doi":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3458.1999.tb00083.x","pdf_url":null,"source":{"id":"https://openalex.org/S165828461","display_name":"CNS Drug Reviews","issn_l":"1080-563X","issn":["1080-563X","1527-3458"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Reviews","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.415.1644","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.415.1644","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nevapress.com/cnsdr/full/5/1/13.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W38088827","https://openalex.org/W1481591018","https://openalex.org/W1599716179","https://openalex.org/W1906511305","https://openalex.org/W1964126380","https://openalex.org/W1980479088","https://openalex.org/W1981695661","https://openalex.org/W1983916534","https://openalex.org/W1985905543","https://openalex.org/W1987660189","https://openalex.org/W1992223942","https://openalex.org/W1993957653","https://openalex.org/W1994915643","https://openalex.org/W2003601846","https://openalex.org/W2006148854","https://openalex.org/W2009354777","https://openalex.org/W2010993944","https://openalex.org/W2014546852","https://openalex.org/W2016659621","https://openalex.org/W2016913703","https://openalex.org/W2020448511","https://openalex.org/W2022416584","https://openalex.org/W2023054003","https://openalex.org/W2024361249","https://openalex.org/W2024377859","https://openalex.org/W2026267640","https://openalex.org/W2029149910","https://openalex.org/W2034167332","https://openalex.org/W2035254967","https://openalex.org/W2037767516","https://openalex.org/W2040346940","https://openalex.org/W2045037749","https://openalex.org/W2047399799","https://openalex.org/W2053602869","https://openalex.org/W2064097612","https://openalex.org/W2069284334","https://openalex.org/W2071869098","https://openalex.org/W2079923887","https://openalex.org/W2080168663","https://openalex.org/W2081996497","https://openalex.org/W2083738893","https://openalex.org/W2084143358","https://openalex.org/W2085299097","https://openalex.org/W2086447925","https://openalex.org/W2087883935","https://openalex.org/W2091277339","https://openalex.org/W2102307026","https://openalex.org/W2105062825","https://openalex.org/W2128155972","https://openalex.org/W2130992306","https://openalex.org/W2164135372","https://openalex.org/W2237008908","https://openalex.org/W2318592937","https://openalex.org/W2326927314","https://openalex.org/W2412865542","https://openalex.org/W2467877026"],"related_works":["https://openalex.org/W2078130301","https://openalex.org/W1987325332","https://openalex.org/W2125834859","https://openalex.org/W2614833439","https://openalex.org/W2418582113","https://openalex.org/W2525266014","https://openalex.org/W2042549454","https://openalex.org/W1602442700","https://openalex.org/W2040510018","https://openalex.org/W1599716179"],"abstract_inverted_index":{"Metrifonate":[0],"(O,O-dimethyl-(1-hydroxy-2,2,2-trichloroethyl)-phosphonate)":[1],"was":[2],"introduced":[3],"as":[4],"a":[5,41],"drug":[6],"for":[7,35],"the":[8,13,24,32],"treatment":[9],"of":[10],"schistosomiasis":[11],"during":[12],"1960s.":[14],"It":[15],"has":[16],"been":[17],"used":[18],"extensively":[19],"in":[20],"developing":[21],"countries":[22],"around":[23],"world,":[25],"and,":[26],"although":[27],"it":[28,39],"is":[29],"no":[30],"longer":[31],"first-line":[33],"medication":[34],"this":[36],"helminthic":[37],"infection,":[38],"remains":[40],"World":[42],"Health":[43],"Organization":[44]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
