{"id":"https://openalex.org/W2002671615","doi":"https://doi.org/10.1021/ol9906211","title":"Catalysis and Acceleration of Acyl Transfer by Aminocyclodextrins: A Biomimetic System of Use in Enzyme Modeling and Drug Design","display_name":"Catalysis and Acceleration of Acyl Transfer by Aminocyclodextrins: A Biomimetic System of Use in Enzyme Modeling and Drug Design","publication_year":1999,"publication_date":"1999-08-21","ids":{"openalex":"https://openalex.org/W2002671615","doi":"https://doi.org/10.1021/ol9906211","mag":"2002671615","pmid":"https://pubmed.ncbi.nlm.nih.gov/10823212"},"language":"en","primary_location":{"id":"doi:10.1021/ol9906211","doi":"https://doi.org/10.1021/ol9906211","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol9906211","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069632829","display_name":"Colin G. Ferguson","orcid":"https://orcid.org/0000-0002-9021-4533","observed_orcids":["https://orcid.org/0000-0002-9021-4533"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Colin G. Ferguson","raw_affiliation_strings":["Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020757036","display_name":"Gregory R. J. Thatcher","orcid":"https://orcid.org/0000-0002-7757-1739","observed_orcids":["https://orcid.org/0000-0002-7757-1739"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gregory R. J. Thatcher","raw_affiliation_strings":["Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4621,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76928483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"1","issue":"6","first_page":"829","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-transfer","display_name":"acyl transfer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/enzyme-mimics","display_name":"enzyme mimics","score":0.48399999737739563},{"id":"https://openalex.org/keywords/aminolysis","display_name":"aminolysis","score":0.777999997138977},{"id":"https://openalex.org/keywords/esterolysis","display_name":"esterolysis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hydrolysis","display_name":"hydrolysis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.7239999771118164},{"id":"https://openalex.org/keywords/biomimetic-catalysis","display_name":"biomimetic catalysis","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2777998946","wikidata":"https://www.wikidata.org/wiki/Q4746464","display_name":"Aminolysis","level":3,"score":0.9793911576271057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9101651906967163},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9009950160980225},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.790635347366333},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6158074140548706},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5955040454864502},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5473952889442444},{"id":"https://openalex.org/C2781383373","wikidata":"https://www.wikidata.org/wiki/Q4746436","display_name":"Amino esters","level":3,"score":0.5083310008049011},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4248616695404053},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4246904253959656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16936150193214417}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ol9906211","doi":"https://doi.org/10.1021/ol9906211","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol9906211","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:10823212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10823212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1977675128","https://openalex.org/W1986734415","https://openalex.org/W2034811265","https://openalex.org/W2046903485","https://openalex.org/W2063031518","https://openalex.org/W2068322609","https://openalex.org/W2070466213","https://openalex.org/W2120605226","https://openalex.org/W2134149462","https://openalex.org/W4253433169"],"related_works":["https://openalex.org/W2012102693","https://openalex.org/W2057513327","https://openalex.org/W1986734415","https://openalex.org/W878316518","https://openalex.org/W2040924955","https://openalex.org/W2028863431","https://openalex.org/W2023325541","https://openalex.org/W4250630805","https://openalex.org/W6885083475","https://openalex.org/W2950716734"],"abstract_inverted_index":{"[formula:":[0],"see":[1],"text]":[2],"Aminocyclodextrins":[3],"(ACDs),":[4],"perfunctionalized":[5],"at":[6,24,65],"the":[7],"6-position":[8],"with":[9,21,51],"amino":[10],"groups,":[11],"bind":[12],"phosphonoformate":[13],"(PFA)":[14],"diesters":[15,36,42],"and":[16,28,32,74],"accelerate":[17],"acyl":[18],"transfer":[19],"reactions":[20,49],"high":[22],"efficiency":[23],"neutral":[25],"pH.":[26],"Aminolysis":[27],"esterolysis":[29],"are":[30],"accelerated":[31],"hydrolysis":[33],"of":[34],"PFA":[35,41,63],"is":[37],"catalyzed":[38],"by":[39,62],"ACDs.":[40],"have":[43],"significant":[44,70],"antiviral":[45],"activity.":[46],"The":[47],"rapid":[48],"observed":[50],"ACDs":[52],"show":[53],"that":[54],"biological":[55],"nucleophiles":[56],"may":[57],"undergo":[58],"facile":[59],"covalent":[60],"modification":[61],"esters":[64],"physiological":[66],"pH,":[67],"which":[68],"has":[69],"implications":[71],"for":[72],"prodrug":[73],"drug":[75],"design":[76],"strategies.":[77]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}