{"id":"https://openalex.org/W2002607484","doi":"https://doi.org/10.1002/mnfr.200700101","title":"N\u03b5\u2010carboxymethyllysine\u2010modified proteins are unable to bind to RAGE and activate an inflammatory response","display_name":"N\u03b5\u2010carboxymethyllysine\u2010modified proteins are unable to bind to RAGE and activate an inflammatory response","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2002607484","doi":"https://doi.org/10.1002/mnfr.200700101","mag":"2002607484","pmid":"https://pubmed.ncbi.nlm.nih.gov/18320574"},"language":"en","primary_location":{"id":"doi:10.1002/mnfr.200700101","doi":"https://doi.org/10.1002/mnfr.200700101","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.200700101","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5167/uzh-4576","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039560120","display_name":"Timo M. Buetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Timo M. Buetler","raw_affiliation_strings":["Nestl\u00e9 Research Center, Lausanne, Switzerland. Timo.Buetler@rdls.nestle.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Timo.Buetler@rdls.nestle.com","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047933988","display_name":"Estelle Leclerc","orcid":"https://orcid.org/0000-0003-3707-9974","observed_orcids":["https://orcid.org/0000-0003-3707-9974"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Estelle Leclerc","raw_affiliation_strings":["Florida Atlantic University, Department of Chemistry and Biochemistry, Boca Raton, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Atlantic University, Department of Chemistry and Biochemistry, Boca Raton, FL, USA","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076473289","display_name":"Alexandra Baumeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexandra Baumeyer","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052863119","display_name":"H\u00e9lia Latado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Helia Latado","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042795268","display_name":"John W. Newell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"John Newell","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050007062","display_name":"Oskar Adolfsson","orcid":"https://orcid.org/0000-0001-5875-9026","observed_orcids":["https://orcid.org/0000-0001-5875-9026"]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Oskar Adolfsson","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048250916","display_name":"V\u00e9ronique Parisod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Parisod","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047269405","display_name":"Janique Richoz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Janique Richoz","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016431764","display_name":"Sarah Maurer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sarah Maurer","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053493848","display_name":"Francis Foata","orcid":"https://orcid.org/0000-0002-1624-9682","observed_orcids":["https://orcid.org/0000-0002-1624-9682"]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francis Foata","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008643714","display_name":"Dominique Piguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominique Piguet","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032774721","display_name":"S. Junod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sylviane Junod","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108412676","display_name":"Claus W. Heizmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Claus W. Heizmann","raw_affiliation_strings":["University Children's Hospital, Division of Clinical Chemistry and Biochemistry, Zu\u0308rich, Switzerland","University Children's Hospital, Division of Clinical Chemistry and Biochemistry, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital, Division of Clinical Chemistry and Biochemistry, Zu\u0308rich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]},{"raw_affiliation_string":"University Children's Hospital, Division of Clinical Chemistry and Biochemistry, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036223416","display_name":"Thierry Delatour","orcid":"https://orcid.org/0000-0003-1540-9645","observed_orcids":["https://orcid.org/0000-0003-1540-9645"]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thierry Delatour","raw_affiliation_strings":["Nestle\u0301 Research Center, Lausanne, Switzerland","Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestle\u0301 Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]},{"raw_affiliation_string":"Nestl\u00e9 Research Center, Lausanne, Switzerland. Fax: +41-21-785-8553","institution_ids":["https://openalex.org/I4210112383"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039560120"],"corresponding_institution_ids":["https://openalex.org/I4210112383"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":4.5203,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.95214887,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"52","issue":"3","first_page":"370","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11745","display_name":"Potato Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nepsilon-carboxymethyl-lysine","display_name":"carboxymethyllysine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.906000018119812},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-glycation","display_name":"protein glycation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proinflammatory-signaling","display_name":"pro-inflammatory signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lung-epithelial-cells","display_name":"lung epithelial cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.9680944681167603},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.9096713662147522},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6723310351371765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.582484781742096},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5416508316993713},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.507347047328949},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49569571018218994},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47663578391075134},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4386788010597229},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.41281816363334656},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41057854890823364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38061845302581787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26316308975219727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2463560700416565},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.16166800260543823},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.062061578035354614}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006038","descriptor_name":"Glyoxylates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/mnfr.200700101","doi":"https://doi.org/10.1002/mnfr.200700101","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.200700101","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},{"id":"pmid:18320574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18320574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular nutrition & food research","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:4576","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/4576/10/Buetler_MolNutrFoodRes_2008-1.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/4576/10/Buetler_MolNutrFoodRes_2008-1.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Buetler, T M; Leclerc, E; Baumeyer, A; Latado, H; Newell, J; Adolfsson, O; Parisod, V; Richoz, J; Maurer, S; Foata, F; Piguet, D; Junod, S; Heizmann, C W; Delatour, T (2008). N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response. Molecular Nutrition and Food Research, 52(3):370-378.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/34096","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/34096","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Buetler, T. M., Leclerc, E., Baumeyer, A., Latado, H., Newell, J., Adolfsson, O., Parisod, V., Richoz, J., Maurer, S., Foata, F., Piguet, D., Junod, S., Heizmann, C. W., & Delatour, T. (2008). N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response. Molecular Nutrition & Food Research, 52, 370\u2013378. https://doi.org/10.1002/mnfr.200700101","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-4576","doi":"https://doi.org/10.5167/uzh-4576","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-4576","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5167/uzh-4576","doi":"https://doi.org/10.5167/uzh-4576","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-4576","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W28144601","https://openalex.org/W1949772429","https://openalex.org/W1968022408","https://openalex.org/W1978793468","https://openalex.org/W1986059252","https://openalex.org/W1986493103","https://openalex.org/W1990992376","https://openalex.org/W1992850373","https://openalex.org/W1995282198","https://openalex.org/W1998826717","https://openalex.org/W2004771015","https://openalex.org/W2006356353","https://openalex.org/W2009498637","https://openalex.org/W2011330952","https://openalex.org/W2011443409","https://openalex.org/W2012705127","https://openalex.org/W2015100117","https://openalex.org/W2028227522","https://openalex.org/W2029719937","https://openalex.org/W2044437167","https://openalex.org/W2051851091","https://openalex.org/W2064569101","https://openalex.org/W2068052073","https://openalex.org/W2071675524","https://openalex.org/W2076328193","https://openalex.org/W2080231890","https://openalex.org/W2084751368","https://openalex.org/W2091960651","https://openalex.org/W2094258156","https://openalex.org/W2094781039","https://openalex.org/W2106697731","https://openalex.org/W2108448809","https://openalex.org/W2117690477","https://openalex.org/W2123964031","https://openalex.org/W2141820958","https://openalex.org/W2142060886"],"related_works":["https://openalex.org/W6948730175","https://openalex.org/W2106697731","https://openalex.org/W3038085131","https://openalex.org/W2084751368","https://openalex.org/W2094258156","https://openalex.org/W2057844010","https://openalex.org/W7132626636","https://openalex.org/W1964486895","https://openalex.org/W2006356353","https://openalex.org/W2107304339"],"abstract_inverted_index":{"Advanced":[0],"glycation":[1],"endproducts":[2],"(AGEs)":[3],"containing":[4],"carboxymethyllysine":[5],"(CML)":[6],"modifications":[7],"are":[8,98,112],"generally":[9],"thought":[10],"to":[11,65,100,102,114,131],"be":[12],"ligands":[13],"of":[14,30],"the":[15,28,119,128],"receptor":[16],"for":[17],"AGEs,":[18],"RAGEs.":[19],"It":[20],"has":[21,37],"been":[22,39],"argued":[23],"that":[24,42,93],"this":[25],"results":[26,91],"in":[27,77,86,104,118,141],"activation":[29],"pro-inflammatory":[31,116],"pathways":[32],"and":[33,79,83,135],"diseases.":[34],"However,":[35],"it":[36],"not":[38,126],"shown":[40],"conclusively":[41],"a":[43,105],"CML-modified":[44,94],"protein":[45],"can":[46,72],"interact":[47,74,81,132],"directly":[48],"with":[49,75,82,133],"RAGE.":[50],"Here,":[51],"we":[52],"have":[53],"analyzed":[54],"whether":[55],"beta-lactoglobulin":[56],"(bLG)":[57],"or":[58,96],"human":[59],"serum":[60],"albumin":[61],"(HSA)":[62],"modified":[63],"chemically":[64],"contain":[66],"only":[67],"CML":[68,123],"(10-40%":[69],"lysine":[70],"modification)":[71],"(i)":[73],"RAGE":[76,85,103,134],"vitro":[78],"(ii)":[80],"activate":[84,115,136],"lung":[87],"epithelial":[88],"cells.":[89,143],"Our":[90],"show":[92],"bLG":[95],"HSA":[97],"unable":[99,113],"bind":[101],"cell-free":[106],"assay":[107],"system":[108],"(Biacore).":[109],"Furthermore,":[110],"they":[111],"signaling":[117,139],"cellular":[120],"system.":[121],"Thus,":[122],"probably":[124],"does":[125],"form":[127],"necessary":[129],"structure(s)":[130],"an":[137],"inflammatory":[138],"cascade":[140],"RAGE-expressing":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}