{"id":"https://openalex.org/W2002605587","doi":"https://doi.org/10.1667/rr2235.1","title":"Transgenic Biosynthesis of Trypanothione Protects Escherichia coli from Radiation-Induced Toxicity","display_name":"Transgenic Biosynthesis of Trypanothione Protects Escherichia coli from Radiation-Induced Toxicity","publication_year":2010,"publication_date":"2010-08-26","ids":{"openalex":"https://openalex.org/W2002605587","doi":"https://doi.org/10.1667/rr2235.1","mag":"2002605587","pmid":"https://pubmed.ncbi.nlm.nih.gov/20726720","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942016"},"language":"en","primary_location":{"id":"doi:10.1667/rr2235.1","doi":"https://doi.org/10.1667/rr2235.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr2235.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082255064","display_name":"Matthew P. Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew P. Fitzgerald","raw_affiliation_strings":["Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa Free Radical and Radiation Biology Program, Montevideo, Uruguay","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa Free Radical and Radiation Biology Program, Montevideo, Uruguay","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joshua M. Madsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M. Madsen","raw_affiliation_strings":["aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005845679","display_name":"Mitchell C. Coleman","orcid":"https://orcid.org/0000-0002-5116-801X","observed_orcids":["https://orcid.org/0000-0002-5116-801X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell C. Coleman","raw_affiliation_strings":["aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064927700","display_name":"Melissa L.T. Teoh-Fitzgerald","orcid":"https://orcid.org/0000-0001-9765-6812","observed_orcids":["https://orcid.org/0000-0001-9765-6812"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. T. Teoh","raw_affiliation_strings":["aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086028754","display_name":"Scott G. Westphal","orcid":"https://orcid.org/0000-0001-5843-0677","observed_orcids":["https://orcid.org/0000-0001-5843-0677"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott G. Westphal","raw_affiliation_strings":["bThe University of Iowa Carver College of Medicine","The University of Iowa, Carver College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bThe University of Iowa Carver College of Medicine","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa, Carver College of Medicine","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044316011","display_name":"Douglas R. Spitz","orcid":"https://orcid.org/0000-0002-1254-8765","observed_orcids":["https://orcid.org/0000-0002-1254-8765"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Spitz","raw_affiliation_strings":["aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["cFaculdad de Medicina, Universidad de la R\u00e9publica de Uruguay, Montevideo, Uruguay","Faculdad de Medicina, Universidad de la R\u00e9publica de Uruguay,Montevideo,Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cFaculdad de Medicina, Universidad de la R\u00e9publica de Uruguay, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Faculdad de Medicina, Universidad de la R\u00e9publica de Uruguay,Montevideo,Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070049424","display_name":"Frederick E. Domann","orcid":"https://orcid.org/0000-0002-0489-2179","observed_orcids":["https://orcid.org/0000-0002-0489-2179"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick E. Domann","raw_affiliation_strings":["aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aThe University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782","https://openalex.org/I4390039339"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2986,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79154172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"174","issue":"3","first_page":"290","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanothione","display_name":"trypanothione","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.8289999961853027},{"id":"https://openalex.org/keywords/transgenic-escherichia-coli","display_name":"transgenic Escherichia coli","score":0.8370000123977661},{"id":"https://openalex.org/keywords/trypanothione-synthetase","display_name":"trypanothione synthetase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/trypanothione-reductase","display_name":"trypanothione reductase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gamma-radiation-resistance","display_name":"gamma radiation resistance","score":0.6930000185966492},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6179999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/amifostine","display_name":"amifostine","score":0.7269999980926514},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7410725951194763},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.7173857688903809},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.5594639778137207},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5486987829208374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5400770902633667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5233506560325623},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5107710361480713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34415966272354126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3047063946723938},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.30427318811416626},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18229427933692932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11813965439796448}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1667/rr2235.1","doi":"https://doi.org/10.1667/rr2235.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr2235.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:20726720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20726720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2167854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2942016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942016","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Radiat Res","raw_type":"Text"},{"id":"pmh:10.1667/RR2235.1","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1667/RR2235.1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2167854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2942016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5548254863","display_name":"University of Iowa Clinical and Translational Science Program (UL1)","funder_award_id":"UL1RR024979","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000868713","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA086862","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W346827628","https://openalex.org/W1604646983","https://openalex.org/W1968005725","https://openalex.org/W1973543110","https://openalex.org/W1976507459","https://openalex.org/W1983582054","https://openalex.org/W1983909677","https://openalex.org/W1996617516","https://openalex.org/W1998829644","https://openalex.org/W2023178182","https://openalex.org/W2023356380","https://openalex.org/W2042320307","https://openalex.org/W2049589006","https://openalex.org/W2059775525","https://openalex.org/W2063555332","https://openalex.org/W2073161317","https://openalex.org/W2074254361","https://openalex.org/W2091022241","https://openalex.org/W2108255104","https://openalex.org/W2110130136","https://openalex.org/W2127982898","https://openalex.org/W2128523126","https://openalex.org/W2134865352","https://openalex.org/W2154261496","https://openalex.org/W2155159495","https://openalex.org/W2162970254","https://openalex.org/W2314179356","https://openalex.org/W2318621416"],"related_works":["https://openalex.org/W2108255104","https://openalex.org/W2060285563","https://openalex.org/W2057988032","https://openalex.org/W2791196721","https://openalex.org/W2606172871","https://openalex.org/W2982452652","https://openalex.org/W2560680778","https://openalex.org/W1777021635","https://openalex.org/W7100779704","https://openalex.org/W2020460612"],"abstract_inverted_index":{"Trypanothione":[0,85],"is":[1,18],"a":[2,19,33,51,195],"unique":[3],"diglutathionyl-spermidine":[4],"conjugate":[5],"found":[6],"in":[7,9,13,56,87,93,119,179],"abundance":[8],"trypanosomes":[10],"but":[11],"not":[12],"other":[14],"eukaryotes.":[15],"Because":[16],"trypanothione":[17,47,63,123,134,151,171,193],"naturally":[20],"occurring":[21],"polyamine":[22],"thiol":[23],"reminiscent":[24],"of":[25,97,122,150,191],"the":[26,62,120,129,158,170,189],"synthetic":[27],"drug":[28],"amifostine,":[29],"it":[30],"may":[31],"be":[32,165],"useful":[34],"protector":[35],"against":[36],"radiation":[37,144],"and":[38,65,76,83,174],"oxidative":[39],"stress.":[40],"For":[41],"these":[42],"reasons":[43],"we":[44,154],"hypothesized":[45],"that":[46,161],"might":[48],"serve":[49],"as":[50,101,194],"radioprotective":[52,197],"agent":[53],"when":[54],"produced":[55],"bacteria.":[57,127],"To":[58],"accomplish":[59],"this":[60],"objective,":[61],"synthetase":[64],"reductase":[66],"genes":[67],"from":[68,113],"T.":[69],"cruzi":[70],"were":[71,135],"introduced":[72],"into":[73],"E.":[74,107,131,147,162],"coli":[75,108,132,148,163],"their":[77,180],"expression":[78],"was":[79,111],"verified":[80],"by":[81,90,103,117,141],"qPCR":[82],"immunoblotting.":[84],"synthesis":[86],"bacteria,":[88],"detected":[89],"HPLC,":[91],"resulted":[92],"decreased":[94],"intracellular":[95],"levels":[96],"reactive":[98],"oxygen":[99],"species":[100],"determined":[102],"H(2)DCFDA":[104],"oxidation.":[105],"Moreover,":[106],"genomic":[109],"DNA":[110,115],"protected":[112],"radiation-induced":[114],"damage":[116],"4.6-fold":[118],"presence":[121],"compared":[124,145],"to":[125,139,146,168,187],"control":[126],"Concordantly,":[128],"transgenic":[130],"expressing":[133],"4.3-fold":[136],"more":[137],"resistant":[138],"killing":[140],"(137)Cs":[142],"gamma":[143],"devoid":[149],"expression.":[152],"Thus":[153],"have":[155],"shown":[156],"for":[157],"first":[159],"time":[160],"can":[164],"genetically":[166],"engineered":[167],"express":[169],"biosynthetic":[172],"pathway":[173],"produce":[175],"trypanothione,":[176],"which":[177],"results":[178,183],"radioresistance.":[181],"These":[182],"warrant":[184],"further":[185],"research":[186],"explore":[188],"possibility":[190],"developing":[192],"novel":[196],"agent.":[198]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
