{"id":"https://openalex.org/W2002604364","doi":"https://doi.org/10.1101/gr.163014.113","title":"Tempo and mode of regulatory evolution in Drosophila","display_name":"Tempo and mode of regulatory evolution in Drosophila","publication_year":2014,"publication_date":"2014-02-24","ids":{"openalex":"https://openalex.org/W2002604364","doi":"https://doi.org/10.1101/gr.163014.113","mag":"2002604364","pmid":"https://pubmed.ncbi.nlm.nih.gov/24567308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4009609"},"language":"en","primary_location":{"id":"doi:10.1101/gr.163014.113","doi":"https://doi.org/10.1101/gr.163014.113","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.163014.113","pdf_url":"http://genome.cshlp.org/content/24/5/797.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://genome.cshlp.org/content/24/5/797.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064925364","display_name":"Joseph D. Coolon","orcid":"https://orcid.org/0000-0003-1591-9418","observed_orcids":["https://orcid.org/0000-0003-1591-9418"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Coolon","raw_affiliation_strings":["University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA;","1University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA;","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"1University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088627617","display_name":"C. Joel McManus","orcid":"https://orcid.org/0000-0002-6605-2642","observed_orcids":["https://orcid.org/0000-0002-6605-2642"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Joel McManus","raw_affiliation_strings":["2Carnegie Mellon University, Department of Biological Sciences, Pittsburgh, Pennsylvania 15213, USA","3University of Connecticut Health Center, Institute for Systems Genomics, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Carnegie Mellon University, Department of Biological Sciences, Pittsburgh, Pennsylvania 15213, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"3University of Connecticut Health Center, Institute for Systems Genomics, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348687","display_name":"Kraig R. Stevenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kraig R. Stevenson","raw_affiliation_strings":["4University of Michigan, Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Michigan, Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376185","display_name":"Brenton R. Graveley","orcid":"https://orcid.org/0000-0001-5777-5892","observed_orcids":["https://orcid.org/0000-0001-5777-5892"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenton R. Graveley","raw_affiliation_strings":["3University of Connecticut Health Center, Institute for Systems Genomics, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Connecticut Health Center, Institute for Systems Genomics, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033807850","display_name":"Patricia Jean Wittkopp","orcid":"https://orcid.org/0000-0001-7619-0048","observed_orcids":["https://orcid.org/0000-0001-7619-0048"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia J. Wittkopp","raw_affiliation_strings":["1University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA","4University of Michigan, Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan 48109, USA","5University of Michigan, Department of Molecular, Cellular, and Developmental Biology, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Michigan, Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"4University of Michigan, Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"5University of Michigan, Department of Molecular, Cellular, and Developmental Biology, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033807850"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":193,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"5","first_page":"797","last_page":"808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.37229999899864197,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.37229999899864197,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.24279999732971191,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.15049999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-evolution","display_name":"regulatory evolution","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gene-expression-divergence","display_name":"gene expression divergence","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cis-regulatory-divergence","display_name":"cis-regulatory divergence","score":0.8629999756813049},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8479999899864197},{"id":"https://openalex.org/keywords/divergence-time","display_name":"divergence time","score":0.7419999837875366},{"id":"https://openalex.org/keywords/compensatory-changes","display_name":"compensatory changes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hybrid-gene-expression","display_name":"hybrid gene expression","score":0.6420000195503235},{"id":"https://openalex.org/keywords/drosophila-sechellia","display_name":"Drosophila sechellia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.9570000171661377},{"id":"https://openalex.org/keywords/phenotypic-divergence","display_name":"phenotypic divergence","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8832077980041504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6690318584442139},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6178159713745117},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.6110415458679199},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5736405849456787},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.5582886338233948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5546548962593079},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5539313554763794},{"id":"https://openalex.org/C2780767217","wikidata":"https://www.wikidata.org/wiki/Q5532421","display_name":"Generality","level":2,"score":0.5434842109680176},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5161734223365784},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.49028876423835754},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.47914236783981323},{"id":"https://openalex.org/C109186463","wikidata":"https://www.wikidata.org/wiki/Q1230536","display_name":"Genetic divergence","level":4,"score":0.4513331353664398},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4499165713787079},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.4181327521800995},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.22013574838638306},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.20515885949134827},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08972683548927307},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1101/gr.163014.113","doi":"https://doi.org/10.1101/gr.163014.113","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.163014.113","pdf_url":"http://genome.cshlp.org/content/24/5/797.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2989823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4009609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4009609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4009609","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmid:24567308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24567308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:genome:24/5/797","doi":null,"is_oa":false,"landing_page_url":"http://genome.cshlp.org/cgi/content/short/24/5/797","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1101/gr.163014.113","doi":"https://doi.org/10.1101/gr.163014.113","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.163014.113","pdf_url":"http://genome.cshlp.org/content/24/5/797.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1813998119","display_name":"Using next-generation sequencing to understand the evolution of gene regulation","funder_award_id":"F32GM089009","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G319763173","display_name":"The Evolution of Gene Expression: Molecular Mechanisms and Inheritance Patterns Revealed on a Genomic Scale With Next-Generation Sequencing","funder_award_id":"1021398","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3448066749","display_name":"Trans-Splicing in Drosophila","funder_award_id":"R01GM095296","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3530300517","display_name":"IGERT: Open Data: Graduate Training for Data Sharing and Reuse in E-Science","funder_award_id":"0903629","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002604364.pdf","grobid_xml":"https://content.openalex.org/works/W2002604364.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W18256236","https://openalex.org/W1586371200","https://openalex.org/W1968376884","https://openalex.org/W1970900633","https://openalex.org/W1971977350","https://openalex.org/W1979317140","https://openalex.org/W1980678014","https://openalex.org/W1981026612","https://openalex.org/W1982510939","https://openalex.org/W1983275320","https://openalex.org/W1986183145","https://openalex.org/W1986497280","https://openalex.org/W1988865197","https://openalex.org/W1989143204","https://openalex.org/W1989271920","https://openalex.org/W1990338025","https://openalex.org/W1991130603","https://openalex.org/W1991311588","https://openalex.org/W1995649500","https://openalex.org/W2006378142","https://openalex.org/W2006882445","https://openalex.org/W2011289056","https://openalex.org/W2020766456","https://openalex.org/W2025943989","https://openalex.org/W2041910571","https://openalex.org/W2043687119","https://openalex.org/W2045070305","https://openalex.org/W2046747589","https://openalex.org/W2053369320","https://openalex.org/W2054624670","https://openalex.org/W2054837796","https://openalex.org/W2063313162","https://openalex.org/W2066157707","https://openalex.org/W2067266410","https://openalex.org/W2067620870","https://openalex.org/W2070494252","https://openalex.org/W2072605474","https://openalex.org/W2072703310","https://openalex.org/W2075749311","https://openalex.org/W2076626517","https://openalex.org/W2085454778","https://openalex.org/W2090982963","https://openalex.org/W2093477772","https://openalex.org/W2094005099","https://openalex.org/W2095178364","https://openalex.org/W2095295625","https://openalex.org/W2096719970","https://openalex.org/W2097109507","https://openalex.org/W2097782352","https://openalex.org/W2099517971","https://openalex.org/W2100640908","https://openalex.org/W2100705274","https://openalex.org/W2103999749","https://openalex.org/W2111811789","https://openalex.org/W2115632577","https://openalex.org/W2116686110","https://openalex.org/W2116816847","https://openalex.org/W2116843300","https://openalex.org/W2121547736","https://openalex.org/W2123878394","https://openalex.org/W2124905066","https://openalex.org/W2125321608","https://openalex.org/W2128016314","https://openalex.org/W2131690896","https://openalex.org/W2133147430","https://openalex.org/W2135229155","https://openalex.org/W2143492752","https://openalex.org/W2145476225","https://openalex.org/W2145726016","https://openalex.org/W2150989284","https://openalex.org/W2155284904","https://openalex.org/W2155504414","https://openalex.org/W2155593623","https://openalex.org/W2157600799","https://openalex.org/W2159340058","https://openalex.org/W2160697089","https://openalex.org/W2161106528","https://openalex.org/W2161376294","https://openalex.org/W2164875056","https://openalex.org/W2166071280","https://openalex.org/W2167364244","https://openalex.org/W2167725902","https://openalex.org/W2168365989","https://openalex.org/W2170800086","https://openalex.org/W2171193618","https://openalex.org/W2320659487","https://openalex.org/W2582743722","https://openalex.org/W4255103122"],"related_works":["https://openalex.org/W2591306338","https://openalex.org/W6941150429","https://openalex.org/W2085454778","https://openalex.org/W1968376884","https://openalex.org/W18727036","https://openalex.org/W2155593623","https://openalex.org/W2589502865","https://openalex.org/W3042146259","https://openalex.org/W2135229155","https://openalex.org/W6990972432"],"abstract_inverted_index":{"Genetic":[0],"changes":[1,63,110,165],"affecting":[2],"gene":[3,15,75,116,123,211],"expression":[4,16,28,76,117,124,154,160,212],"contribute":[5],"to":[6,51,59,93,118],"phenotypic":[7],"divergence;":[8],"thus,":[9],"understanding":[10,23],"how":[11,61],"regulatory":[12,38,62],"networks":[13],"controlling":[14],"change":[17],"over":[18],"time":[19,145],"is":[20],"critical":[21],"for":[22,222],"evolution.":[24,224],"Prior":[25],"studies":[26,47],"of":[27,37,55,81,86,108,115,132,136,149,153,159,185],"differences":[29,44],"within":[30],"and":[31,42,79,89,97,100,218],"between":[32],"species":[33,80,179],"have":[34],"identified":[35],"properties":[36,57],"divergence,":[39],"but":[40,214],"technical":[41],"biological":[43],"among":[45,77],"these":[46,56,71],"make":[48],"it":[49],"difficult":[50],"assess":[52],"the":[53,106,113,130,147,157,207,216],"generality":[54],"or":[58],"understand":[60],"accumulate":[64],"with":[65,83,134,143,151,170],"divergence":[66,87,138,144,161,171,187],"time.":[67],"Here,":[68],"we":[69,127,189],"address":[70],"issues":[72],"by":[73,163],"comparing":[74],"strains":[78],"Drosophila":[82],"a":[84],"range":[85],"times":[88],"use":[90],"F1":[91],"hybrids":[92],"examine":[94],"inheritance":[95],"patterns":[96],"disentangle":[98],"cis-":[99],"trans-regulatory":[101],"changes.":[102],"We":[103],"find":[104],"that":[105,129,188],"fixation":[107],"compensatory":[109],"has":[111,139],"caused":[112],"regulation":[114],"diverge":[119],"more":[120,141],"rapidly":[121,142],"than":[122,146],"itself.":[125],"Specifically,":[126],"observed":[128],"proportion":[131,148],"genes":[133,150],"evidence":[135,152],"cis-regulatory":[137,164,186],"increased":[140],"differences.":[155],"Surprisingly,":[156],"amount":[158],"explained":[162],"did":[166],"not":[167,205],"increase":[168],"steadily":[169],"time,":[172],"as":[173],"was":[174],"previously":[175],"proposed.":[176],"Rather,":[177],"one":[178],"(Drosophila":[180],"sechellia)":[181],"showed":[182],"an":[183],"excess":[184],"argue":[190],"most":[191],"likely":[192],"resulted":[193],"from":[194],"positive":[195],"selection":[196],"in":[197],"this":[198,202,223],"lineage.":[199],"Taken":[200],"together,":[201],"work":[203],"reveals":[204],"only":[206],"rate":[208],"at":[209],"which":[210],"evolves,":[213],"also":[215],"molecular":[217],"evolutionary":[219],"mechanisms":[220],"responsible":[221]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
