{"id":"https://openalex.org/W2002581355","doi":"https://doi.org/10.1371/journal.ppat.1003774","title":"Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice","display_name":"Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice","publication_year":2013,"publication_date":"2013-12-05","ids":{"openalex":"https://openalex.org/W2002581355","doi":"https://doi.org/10.1371/journal.ppat.1003774","mag":"2002581355","pmid":"https://pubmed.ncbi.nlm.nih.gov/24348248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857797"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1003774","doi":"https://doi.org/10.1371/journal.ppat.1003774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003774","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003774&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003774&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057702452","display_name":"Bastian Hatesuer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Bastian Hatesuer","raw_affiliation_strings":["Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084176911","display_name":"Stephanie Bertram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801496451","display_name":"German Primate Center","ror":"https://ror.org/02f99v835","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801496451","https://openalex.org/I315704651"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Bertram","raw_affiliation_strings":["Infection Biology Unit, German Primate Center, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Biology Unit, German Primate Center, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I2801496451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086238755","display_name":"Mehnert Nora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nora Mehnert","raw_affiliation_strings":["Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065345242","display_name":"Mahmoud Mohamed Bahgat","orcid":"https://orcid.org/0000-0002-6485-8722","observed_orcids":["https://orcid.org/0000-0002-6485-8722"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Mahmoud M. Bahgat","raw_affiliation_strings":["Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. Nelson","raw_affiliation_strings":["Divisons of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisons of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004595481","display_name":"Stefan P\u00f6hlmann","orcid":"https://orcid.org/0000-0001-6086-9136","observed_orcids":["https://orcid.org/0000-0001-6086-9136"]},"institutions":[{"id":"https://openalex.org/I2801496451","display_name":"German Primate Center","ror":"https://ror.org/02f99v835","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801496451","https://openalex.org/I315704651"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan P\u00f6hlman","raw_affiliation_strings":["Infection Biology Unit, German Primate Center, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Biology Unit, German Primate Center, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I2801496451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038499176","display_name":"Klaus Schughart","orcid":"https://orcid.org/0000-0002-6824-7523","observed_orcids":["https://orcid.org/0000-0002-6824-7523"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Klaus Schughart","raw_affiliation_strings":["Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210124929"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038499176"],"corresponding_institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210124929"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":8.1867,"has_fulltext":true,"cited_by_count":192,"citation_normalized_percentile":{"value":0.98297231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"12","first_page":"e1003774","last_page":"e1003774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hemagglutinin-cleavage","display_name":"hemagglutinin cleavage","score":0.8799999952316284},{"id":"https://openalex.org/keywords/host-cell-proteases","display_name":"host cell proteases","score":0.7519999742507935},{"id":"https://openalex.org/keywords/2009-h1n1-pandemic","display_name":"2009 H1N1 pandemic","score":0.8339999914169312},{"id":"https://openalex.org/keywords/h3n2-influenza-a-virus","display_name":"H3N2 influenza A virus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/viral-spread","display_name":"viral spread","score":0.6029999852180481},{"id":"https://openalex.org/keywords/pulmonary-pathology","display_name":"lung pathology","score":0.6690000295639038},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7413440346717834},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.7291375994682312},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7180782556533813},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.680079460144043},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6774412989616394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6514334678649902},{"id":"https://openalex.org/C82988372","wikidata":"https://www.wikidata.org/wiki/Q5628866","display_name":"H5N1 genetic structure","level":5,"score":0.5617107152938843},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.5262355208396912},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.5238652229309082},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5206705331802368},{"id":"https://openalex.org/C86282344","wikidata":"https://www.wikidata.org/wiki/Q575314","display_name":"Antigenic shift","level":5,"score":0.46432843804359436},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.4417875409126282},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34469544887542725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1429823637008667},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.11324989795684814},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0935245156288147},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.08336976170539856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D053122","descriptor_name":"Influenza A Virus, H3N2 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.ppat.1003774","doi":"https://doi.org/10.1371/journal.ppat.1003774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003774","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003774&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2845104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3857797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:24348248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24348248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:repository.helmholtz-hzi.de:10033/306641","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10033/306641","pdf_url":"https://repository.helmholtz-hzi.de/bitstream/10033/306641/1/Hatesuer%20et%20al_final.pdf","source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.6478","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.6478","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/10/d8/ppat.1003774.PMC3857797.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7cdc567aa0b24c34ae5832e23347ce0d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7cdc567aa0b24c34ae5832e23347ce0d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 9, Iss 12, p e1003774 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/869047","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Tmprss2_Is_Essential_for_Influenza_H1N1_Virus_Pathogenesis_in_Mice_/869047","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:goescholar:1/9512","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/9512","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:hzi.openrepository.com:10033/306641","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10033/306641","pdf_url":null,"source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/60701","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/60701","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1003774","doi":"https://doi.org/10.1371/journal.ppat.1003774","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003774","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003774&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2577379633","display_name":"Mechanisms and Markers of Prostate Cancer Metastases","funder_award_id":"P01CA085859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002581355.pdf","grobid_xml":"https://content.openalex.org/works/W2002581355.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W114652413","https://openalex.org/W193865296","https://openalex.org/W1507765665","https://openalex.org/W1547086125","https://openalex.org/W1558753212","https://openalex.org/W1972032770","https://openalex.org/W1976400886","https://openalex.org/W1980823976","https://openalex.org/W1993337771","https://openalex.org/W1997414761","https://openalex.org/W2008121982","https://openalex.org/W2012915017","https://openalex.org/W2013453931","https://openalex.org/W2017148875","https://openalex.org/W2029674444","https://openalex.org/W2034880469","https://openalex.org/W2048010092","https://openalex.org/W2049949004","https://openalex.org/W2057104879","https://openalex.org/W2064076043","https://openalex.org/W2069358581","https://openalex.org/W2087291913","https://openalex.org/W2098086455","https://openalex.org/W2099045066","https://openalex.org/W2099549544","https://openalex.org/W2101506295","https://openalex.org/W2102637313","https://openalex.org/W2104201091","https://openalex.org/W2105278533","https://openalex.org/W2106842109","https://openalex.org/W2126352919","https://openalex.org/W2137034000","https://openalex.org/W2137956145","https://openalex.org/W2139838713","https://openalex.org/W2139942977","https://openalex.org/W2140674451","https://openalex.org/W2142861733","https://openalex.org/W2160527857","https://openalex.org/W2167444679"],"related_works":["https://openalex.org/W2287495486","https://openalex.org/W1965400930","https://openalex.org/W2330268838","https://openalex.org/W2920147347","https://openalex.org/W2084981497","https://openalex.org/W3019098228","https://openalex.org/W2106842109","https://openalex.org/W2945668924","https://openalex.org/W2887166156","https://openalex.org/W2613674576"],"abstract_inverted_index":{"Annual":[0],"influenza":[1,39,59,77,110,117,144,180,205],"epidemics":[2],"and":[3,124,133,150,173,198,203],"occasional":[4],"pandemics":[5],"pose":[6],"a":[7,97,190],"severe":[8,154],"threat":[9],"to":[10,31,73,83,159],"human":[11],"health.":[12],"Host":[13],"cell":[14,45,69,192],"factors":[15],"required":[16],"for":[17,22,28,49,195],"viral":[18,50,171,196],"spread":[19,106,172,197],"but":[20],"not":[21,168],"cellular":[23],"survival":[24,151],"are":[25],"attractive":[26],"targets":[27],"novel":[29],"approaches":[30],"antiviral":[32],"intervention.":[33],"The":[34],"cleavage":[35,86],"activation":[36,87],"of":[37,96,107,135,200],"the":[38,74,89,113],"virus":[40,146],"hemagglutinin":[41],"(HA)":[42],"by":[43],"host":[44,191],"proteases":[46,57],"is":[47,54],"essential":[48,194],"infectivity.":[51],"However,":[52],"it":[53],"unknown":[55],"which":[56],"activate":[58],"viruses":[60,78],"in":[61,68,88,103,155],"mammals.":[62],"Several":[63],"candidates":[64],"have":[65],"been":[66],"identified":[67],"culture":[70],"studies,":[71],"leading":[72],"concept":[75],"that":[76,94],"can":[79],"employ":[80],"multiple":[81],"enzymes":[82],"ensure":[84],"their":[85],"host.":[90],"Here,":[91],"we":[92],"show":[93],"deletion":[95],"single":[98],"HA-activating":[99],"protease":[100],"gene,":[101],"Tmprss2,":[102],"mice":[104,126,166],"inhibits":[105],"mono-basic":[108,142,201],"H1N1":[109,202],"viruses,":[111],"including":[112],"pandemic":[114],"2009":[115],"swine":[116],"virus.":[118,182],"Lung":[119],"pathology":[120,174],"was":[121,152],"strongly":[122],"reduced":[123],"mutant":[125,157],"were":[127,167],"protected":[128,169],"from":[129,170],"weight":[130,148],"loss,":[131],"death":[132],"impairment":[134],"lung":[136],"function.":[137],"Also,":[138],"after":[139,175],"infection":[140,176],"with":[141,177],"H3N2":[143,204],"A":[145,181,206],"body":[147],"loss":[149],"less":[153],"Tmprss2":[156],"compared":[158],"wild":[160],"type":[161],"mice.":[162],"As":[163],"expected,":[164],"Tmprss2-deficient":[165],"multi-basic":[178],"H7N7":[179],"In":[183],"conclusion,":[184],"these":[185],"results":[186],"identify":[187],"TMPRSS2":[188],"as":[189],"factor":[193],"pathogenesis":[199],"viruses.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}