{"id":"https://openalex.org/W2002467112","doi":"https://doi.org/10.1002/jcp.21926","title":"Induction of Th17 differentiation by corneal epithelial\u2010derived cytokines","display_name":"Induction of Th17 differentiation by corneal epithelial\u2010derived cytokines","publication_year":2009,"publication_date":"2009-09-10","ids":{"openalex":"https://openalex.org/W2002467112","doi":"https://doi.org/10.1002/jcp.21926","mag":"2002467112","pmid":"https://pubmed.ncbi.nlm.nih.gov/19746420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789678"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.21926","doi":"https://doi.org/10.1002/jcp.21926","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.21926","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789678","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100710542","display_name":"Xiaofen Zheng","orcid":"https://orcid.org/0000-0003-0206-3040","observed_orcids":["https://orcid.org/0000-0003-0206-3040"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210132355","display_name":"Shanxi Eye Hospital","ror":"https://ror.org/02wh8xm70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132355"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaofen Zheng","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA","Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","Shanxi Eye Hospital, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Shanxi Eye Hospital, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I4210132355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101656675","display_name":"Fang Bian","orcid":"https://orcid.org/0000-0002-2938-4584","observed_orcids":["https://orcid.org/0000-0002-2938-4584"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Fang Bian","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","Department of Ophthalmology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Ophthalmology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625534","display_name":"Ping Ma","orcid":"https://orcid.org/0000-0002-1172-2805","observed_orcids":["https://orcid.org/0000-0002-1172-2805"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ping Ma","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","Zhongshan Ophthalmic Center, Sun-Yat Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Zhongshan Ophthalmic Center, Sun-Yat Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119261","display_name":"Cintia Sade de Paiva","orcid":"https://orcid.org/0000-0002-9057-5494","observed_orcids":["https://orcid.org/0000-0002-9057-5494"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cintia S. De Paiva","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024092541","display_name":"Michael E. Stern","orcid":"https://orcid.org/0000-0001-7466-1184","observed_orcids":["https://orcid.org/0000-0001-7466-1184"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Stern","raw_affiliation_strings":["Allergan, Inc., Irvine, California","Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan, Inc., Irvine, California","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086607086","display_name":"Stephen Carl Pflugfelder","orcid":"https://orcid.org/0000-0002-9341-3482","observed_orcids":["https://orcid.org/0000-0002-9341-3482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen C. Pflugfelder","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101882729","display_name":"De\u2010Quan Li","orcid":"https://orcid.org/0000-0001-9449-4686","observed_orcids":["https://orcid.org/0000-0001-9449-4686"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"De\u2010Quan Li","raw_affiliation_strings":["Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101882729"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.866,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.84964697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"222","issue":"1","first_page":"95","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.8849999904632568},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9330000281333923},{"id":"https://openalex.org/keywords/il-17f","display_name":"IL-17F","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyperosmotic-stress","display_name":"hyperosmotic stress","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tlr-ligands","display_name":"TLR ligands","score":0.871999979019165},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.9120000004768372},{"id":"https://openalex.org/keywords/flagellin","display_name":"flagellin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/keratitis","display_name":"keratitis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.5762574076652527},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.5731590986251831},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5500667095184326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5010321140289307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48424598574638367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4753686785697937},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4665009379386902},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4329882264137268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4146580994129181},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35846972465515137},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.2493533492088318},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12646394968032837}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009995","descriptor_name":"Osmosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcp.21926","doi":"https://doi.org/10.1002/jcp.21926","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.21926","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:19746420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19746420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2789678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2789678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1441766796","display_name":"Pathogenesis of Conjunctival Squamous Metaplasia","funder_award_id":"R01EY011915","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2463499466","display_name":null,"funder_award_id":"FY06 PR064719","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G42013391","display_name":null,"funder_award_id":"EY11915","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1491588541","https://openalex.org/W1507483488","https://openalex.org/W1600038678","https://openalex.org/W1822726093","https://openalex.org/W1959664751","https://openalex.org/W1979323310","https://openalex.org/W1979708061","https://openalex.org/W1982926364","https://openalex.org/W1992495439","https://openalex.org/W2002180108","https://openalex.org/W2004186675","https://openalex.org/W2006249161","https://openalex.org/W2008713912","https://openalex.org/W2012077729","https://openalex.org/W2014750930","https://openalex.org/W2015494251","https://openalex.org/W2020153915","https://openalex.org/W2021788075","https://openalex.org/W2024173356","https://openalex.org/W2035027025","https://openalex.org/W2053988957","https://openalex.org/W2066587571","https://openalex.org/W2077762362","https://openalex.org/W2081521873","https://openalex.org/W2085926098","https://openalex.org/W2086264253","https://openalex.org/W2087530820","https://openalex.org/W2088904701","https://openalex.org/W2090831287","https://openalex.org/W2092033904","https://openalex.org/W2092235636","https://openalex.org/W2094509276","https://openalex.org/W2100545178","https://openalex.org/W2112866067","https://openalex.org/W2116828514","https://openalex.org/W2117340681","https://openalex.org/W2124600315","https://openalex.org/W2139008734","https://openalex.org/W2139257870","https://openalex.org/W2155013311","https://openalex.org/W2155779547","https://openalex.org/W2156451877","https://openalex.org/W2172466148","https://openalex.org/W2413662519","https://openalex.org/W2776663677"],"related_works":["https://openalex.org/W1990612986","https://openalex.org/W2067886672","https://openalex.org/W2002180108","https://openalex.org/W4388801903","https://openalex.org/W1640605148","https://openalex.org/W7096707735","https://openalex.org/W2121977118","https://openalex.org/W2276707697","https://openalex.org/W2100675666","https://openalex.org/W1998961766"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,16,48,83,100],"to":[3,41,119,206],"explore":[4],"a":[5,42],"potential":[6],"role":[7],"of":[8,27,34,44,68,94,108,148,162,178],"epithelium-derived":[9],"cytokines":[10,116,198],"in":[11,91,105,123,172],"Th17":[12,14,46,52,89,103,192],"differentiation.":[13],"induction":[15],"evaluated":[17],"by":[18,50,72,126,151,197,200],"murine":[19],"CD4(+)":[20,155],"T":[21,70,156,180],"cells":[22,38,71,90,157,181],"treated":[23],"with":[24,145],"different":[25],"combinations":[26],"five":[28],"inducing":[29,115],"cytokines,":[30],"or":[31,153],"conditioned":[32,146],"media":[33,128,147],"human":[35],"corneal":[36,201],"epithelial":[37],"(HCECs)":[39],"exposed":[40,205],"variety":[43],"stimuli.":[45,211],"differentiation":[47,193],"determined":[49],"measuring":[51],"associated":[53],"molecules,":[54],"IL-17A,":[55,163],"IL-17F,":[56,164],"IL-22,":[57,165],"CCL-20,":[58,166],"and":[59,63,66,75,78,98,136,140,167,175,209],"STAT3":[60],"at":[61],"mRNA":[62,160],"protein":[64,171],"levels,":[65],"numbers":[67,177],"IL-17-producing":[69,179],"real-time":[73],"PCR,":[74],"cytokine":[76],"immunobead":[77],"ELISPOT":[79],"assays,":[80],"respectively.":[81],"IL-23":[82],"the":[84,92,101,106,173,188],"strongest":[85,102],"inducer":[86],"for":[87,187],"expanding":[88],"presence":[93,107],"TGF-beta1":[95,109],"+":[96,110,112],"IL-6;":[97],"IL-1beta":[99],"amplifier":[104],"IL-6":[111],"IL-23.":[113],"These":[114,184],"were":[117],"found":[118],"be":[120,195],"significantly":[121],"stimulated":[122],"HCECs":[124,149],"challenged":[125],"hyperosmotic":[127],"(450":[129],"mOsM),":[130],"microbial":[131],"components":[132],"(polyI:C,":[133],"flagellin,":[134],"R837,":[135],"other":[137],"TLR":[138],"ligands)":[139],"TNF-alpha.":[141],"Interestingly,":[142],"when":[143],"incubated":[144],"irritated":[150],"polyI:C":[152],"TNF-alpha,":[154],"displayed":[158],"increased":[159,169,176],"levels":[161],"STAT3,":[168],"IL-17":[170],"supernatant,":[174],"(Th17":[182],"cells).":[183],"findings":[185],"demonstrate":[186],"first":[189],"time":[190],"that":[191,203],"can":[194],"promoted":[196],"produced":[199],"epithelium":[202],"are":[204],"hyperosmotic,":[207],"microbial,":[208],"inflammatory":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}