{"id":"https://openalex.org/W2002428253","doi":"https://doi.org/10.1074/jbc.m414388200","title":"ATP-dependent and ATP-independent Roles for the Rad54 Chromatin Remodeling Enzyme during Recombinational Repair of a DNA Double Strand Break","display_name":"ATP-dependent and ATP-independent Roles for the Rad54 Chromatin Remodeling Enzyme during Recombinational Repair of a DNA Double Strand Break","publication_year":2005,"publication_date":"2005-01-15","ids":{"openalex":"https://openalex.org/W2002428253","doi":"https://doi.org/10.1074/jbc.m414388200","mag":"2002428253","pmid":"https://pubmed.ncbi.nlm.nih.gov/15653683"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m414388200","doi":"https://doi.org/10.1074/jbc.m414388200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m414388200","pdf_url":"http://www.jbc.org/article/S0021925819304946/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819304946/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049132817","display_name":"Branden S. Wolner","orcid":"https://orcid.org/0000-0003-0021-2073","observed_orcids":["https://orcid.org/0000-0003-0021-2073"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Branden Wolner","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St., Worcester, Massachusetts 01605, USA","Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St., Worcester, Massachusetts 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035490948","display_name":"Craig L. Peterson","orcid":"https://orcid.org/0000-0002-9448-555X","observed_orcids":["https://orcid.org/0000-0002-9448-555X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig L. Peterson","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035490948"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.5175,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.95541746,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"280","issue":"11","first_page":"10855","last_page":"10860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rad54","display_name":"Rad54","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.859000027179718},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rad52","display_name":"RAD52","score":0.7269999980926514},{"id":"https://openalex.org/keywords/single-stranded-dna-binding","display_name":"single-stranded DNA binding","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-strand-invasion","display_name":"DNA strand invasion","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.8318581581115723},{"id":"https://openalex.org/C74054111","wikidata":"https://www.wikidata.org/wiki/Q5891445","display_name":"Homology directed repair","level":5,"score":0.6363987922668457},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6079357266426086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6075906157493591},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5813183784484863},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.5696817636489868},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5251938104629517},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5012485980987549},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4832947552204132},{"id":"https://openalex.org/C158456008","wikidata":"https://www.wikidata.org/wiki/Q412639","display_name":"DNA supercoil","level":4,"score":0.47969719767570496},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.43533387780189514},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4338727593421936},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3404783606529236},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3201116621494293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29103362560272217},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.23131057620048523},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.22810614109039307},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.1640940010547638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09947603940963745},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07534340023994446}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005277","descriptor_name":"Fenfluramine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005277","descriptor_name":"Fenfluramine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008836","descriptor_name":"Micrococcal Nuclease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m414388200","doi":"https://doi.org/10.1074/jbc.m414388200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m414388200","pdf_url":"http://www.jbc.org/article/S0021925819304946/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15653683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15653683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-1696","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m414388200","doi":"https://doi.org/10.1074/jbc.m414388200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m414388200","pdf_url":"http://www.jbc.org/article/S0021925819304946/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3638591765","display_name":"The Role of Rad54 in Recombination Repair of DNA.","funder_award_id":"5f32gm064233-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4420680472","display_name":null,"funder_award_id":"GM 54096","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7428619724","display_name":"Yeast chromatin structure and function","funder_award_id":"R01GM054096","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8011462252","display_name":null,"funder_award_id":"GM64233","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002428253.pdf","grobid_xml":"https://content.openalex.org/works/W2002428253.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1676891985","https://openalex.org/W1966320645","https://openalex.org/W1966407135","https://openalex.org/W1987600396","https://openalex.org/W1990586926","https://openalex.org/W2006895915","https://openalex.org/W2017988777","https://openalex.org/W2022100127","https://openalex.org/W2025972514","https://openalex.org/W2029094445","https://openalex.org/W2038608145","https://openalex.org/W2039196623","https://openalex.org/W2046104827","https://openalex.org/W2057072455","https://openalex.org/W2075087073","https://openalex.org/W2089804282","https://openalex.org/W2090263062","https://openalex.org/W2094810448","https://openalex.org/W2098126099","https://openalex.org/W2098502129","https://openalex.org/W2109038089","https://openalex.org/W2111490168","https://openalex.org/W2113147636","https://openalex.org/W2141312910","https://openalex.org/W2144550200","https://openalex.org/W2150453102","https://openalex.org/W2154317163","https://openalex.org/W2158526159","https://openalex.org/W2576734941","https://openalex.org/W4211163486"],"related_works":["https://openalex.org/W7098089714","https://openalex.org/W7000971747","https://openalex.org/W2101248318","https://openalex.org/W2054199196","https://openalex.org/W2111490168","https://openalex.org/W2006895915","https://openalex.org/W1517652763","https://openalex.org/W133976810","https://openalex.org/W7140188023","https://openalex.org/W2125600180"],"abstract_inverted_index":{"The":[0],"efficient":[1],"and":[2,16,26,84,107],"accurate":[3],"repair":[4,37,86],"of":[5,33,38,44,57,79,87,101,138,144],"DNA":[6,61,81,134],"double":[7],"strand":[8,135],"breaks":[9],"(DSBs)":[10],"is":[11,54],"critical":[12,49],"to":[13,23,76,104,147],"cell":[14],"survival,":[15],"defects":[17],"in":[18,51,69,130,151],"this":[19,112],"process":[20,43,73],"can":[21],"lead":[22],"genome":[24],"instability":[25],"cancers.":[27],"In":[28],"eukaryotes,":[29],"the":[30,36,41,55,58,77,88,94,133,152],"Rad52":[31],"group":[32],"proteins":[34],"dictates":[35],"DSBs":[39],"by":[40],"error-free":[42],"homologous":[45],"recombination":[46],"(HR).":[47],"A":[48],"step":[50,137],"eukaryotic":[52],"HR":[53,153],"formation":[56,78],"initial":[59],"Rad51-single-stranded":[60],"presynaptic":[62,66],"nucleoprotein":[63],"filament.":[64],"This":[65,140],"filament":[67],"participates":[68],"a":[70,80,99,122],"homology":[71],"search":[72],"that":[74,93,111,128],"leads":[75],"joint":[82],"molecule":[83],"recombinational":[85],"DSB.":[89],"Recently,":[90],"we":[91,109],"showed":[92],"Rad54":[95,145],"protein":[96],"functions":[97],"as":[98],"mediator":[100],"Rad51":[102],"binding":[103],"single-stranded":[105],"DNA,":[106],"here,":[108],"find":[110],"activity":[113,143],"does":[114],"not":[115],"require":[116],"ATP":[117],"hydrolysis.":[118],"We":[119],"also":[120],"identify":[121],"novel":[123],"Rad54-dependent":[124],"chromatin":[125],"remodeling":[126,142],"event":[127],"occurs":[129],"vivo":[131],"during":[132],"invasion":[136],"HR.":[139],"ATP-dependent":[141],"appears":[146],"control":[148],"subsequent":[149],"steps":[150],"process.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}