{"id":"https://openalex.org/W2002393526","doi":"https://doi.org/10.1371/journal.pone.0082543","title":"UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin","display_name":"UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin","publication_year":2013,"publication_date":"2013-12-10","ids":{"openalex":"https://openalex.org/W2002393526","doi":"https://doi.org/10.1371/journal.pone.0082543","mag":"2002393526","pmid":"https://pubmed.ncbi.nlm.nih.gov/24340038","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3858337"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0082543","doi":"https://doi.org/10.1371/journal.pone.0082543","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0082543","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082543&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082543&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072717503","display_name":"Haeri Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haeri Choi","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020300580","display_name":"Heather Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Schneider","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078007061","display_name":"Shannon Klum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Klum","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040653487","display_name":"Devon B. Chandler-Brown","orcid":"https://orcid.org/0000-0001-8454-7318","observed_orcids":["https://orcid.org/0000-0001-8454-7318"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devon Chandler-Brown","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072624010","display_name":"Matt R. Kaeberlein","orcid":"https://orcid.org/0000-0002-1311-3421","observed_orcids":["https://orcid.org/0000-0002-1311-3421"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matt Kaeberlein","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075262666","display_name":"Lara S. Shamieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128365640","display_name":"Regis University","ror":"https://ror.org/043ae9h44","country_code":"US","type":"education","lineage":["https://openalex.org/I128365640"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lara Shamieh","raw_affiliation_strings":["Department of Biology, Regis University, Denver, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Regis University, Denver, Colorado, United States of America","institution_ids":["https://openalex.org/I128365640"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072624010","https://openalex.org/A5075262666"],"corresponding_institution_ids":["https://openalex.org/I128365640","https://openalex.org/I201448701"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.1714,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.41418764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"12","first_page":"e82543","last_page":"e82543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11179","display_name":"Nematode management and characterization studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethosuximide","display_name":"ethosuximide","score":1.0},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.9139999747276306},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7490000128746033},{"id":"https://openalex.org/keywords/trimethadione","display_name":"trimethadione","score":0.824999988079071},{"id":"https://openalex.org/keywords/succinimide","display_name":"succinimide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.7570000290870667},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2779619453","wikidata":"https://www.wikidata.org/wiki/Q421567","display_name":"Ethosuximide","level":4,"score":0.9688299298286438},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6726805567741394},{"id":"https://openalex.org/C167552308","wikidata":"https://www.wikidata.org/wiki/Q711849","display_name":"Median lethal dose","level":3,"score":0.46424946188926697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4152091145515442},{"id":"https://openalex.org/C2781449162","wikidata":"https://www.wikidata.org/wiki/Q910277","display_name":"Tocopherol","level":4,"score":0.4128708839416504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3975856900215149},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38517770171165466},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3784947693347931},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31882038712501526},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.17592552304267883},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.1509157121181488},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.13913926482200623},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08173179626464844},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.059266477823257446},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0590415894985199}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0082543","doi":"https://doi.org/10.1371/journal.pone.0082543","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0082543","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082543&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2844117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3858337","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24340038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24340038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3858337","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3858337/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.804.417","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.804.417","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/35/16/pone.0082543.PMC3858337.pdf","raw_type":"text"},{"id":"pmh:oai:epublications.regis.edu:facultypubs-1672","doi":null,"is_oa":false,"landing_page_url":"https://epublications.regis.edu/facultypubs/671","pdf_url":null,"source":{"id":"https://openalex.org/S4377196795","display_name":"ePublications at Regis University (Regis University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I128365640","host_organization_name":"Regis University","host_organization_lineage":["https://openalex.org/I128365640"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regis University Faculty Publications (comprehensive list)","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1ee73a55c3734d3b90426410d95362df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ee73a55c3734d3b90426410d95362df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 12, p e82543 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0082543","doi":"https://doi.org/10.1371/journal.pone.0082543","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0082543","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082543&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4037210613","display_name":"Mechanisms of Life Span Extension and Rejuvenation By Adult Reproductive Diapause","funder_award_id":"R01AG031108","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4072459529","display_name":"Genetic Approaches to Aging","funder_award_id":"T32AG000057","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002393526.pdf","grobid_xml":"https://content.openalex.org/works/W2002393526.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1631908837","https://openalex.org/W1662930619","https://openalex.org/W1983627046","https://openalex.org/W1985647060","https://openalex.org/W1989397237","https://openalex.org/W1991080848","https://openalex.org/W2008371754","https://openalex.org/W2018359498","https://openalex.org/W2023448902","https://openalex.org/W2027212069","https://openalex.org/W2033367887","https://openalex.org/W2040930527","https://openalex.org/W2043738446","https://openalex.org/W2058734423","https://openalex.org/W2061756062","https://openalex.org/W2062629127","https://openalex.org/W2108742602","https://openalex.org/W2129704808","https://openalex.org/W2135479055","https://openalex.org/W2151034892","https://openalex.org/W2159575874","https://openalex.org/W2170979056","https://openalex.org/W2171436932","https://openalex.org/W4321509056"],"related_works":["https://openalex.org/W2027212069","https://openalex.org/W2112421922","https://openalex.org/W1978925174","https://openalex.org/W2012676939","https://openalex.org/W1985647060","https://openalex.org/W2001851127","https://openalex.org/W1977084577","https://openalex.org/W1989397237","https://openalex.org/W2914350445","https://openalex.org/W2803499566"],"abstract_inverted_index":{"The":[0],"anticonvulsant":[1],"ethosuximide":[2,34,71,91,105,128,144,170],"has":[3],"been":[4],"previously":[5],"shown":[6],"to":[7,28,81],"increase":[8],"life":[9,93,133,146],"span":[10,94,147],"and":[11,58,163],"promote":[12],"healthspan":[13],"in":[14,75],"the":[15,53,131,141],"nematode":[16],"Caenorhabditis":[17],"elegans":[18],"at":[19,31,95,101,109,153],"millimolar":[20],"concentrations.":[21],"Here":[22],"we":[23],"report":[24],"that":[25,40,78,143,151],"following":[26,65],"exposure":[27],"ultraviolet":[29],"irradiation":[30],"254":[32],"nm,":[33],"is":[35,48,72],"converted":[36],"into":[37,171],"a":[38,149,172],"compound":[39,174],"displays":[41],"toxicity":[42,82,108,122],"toward":[43],"C.":[44],"elegans.":[45],"This":[46],"effect":[47],"specific":[49],"for":[50],"ethosuximide,":[51,125],"as":[52],"structurally":[54],"related":[55],"compounds":[56],"trimethadione":[57],"succinimide":[59],"do":[60],"not":[61,73,100,119],"show":[62],"similar":[63,107],"toxicities":[64],"UV":[66,176],"exposure.":[67],"Killing":[68],"by":[69,115,148,160,175],"UV-irradiated":[70],"attenuated":[74],"chemosensory":[76],"mutants":[77],"are":[79],"resistant":[80],"associated":[83],"with":[84],"high":[85],"doses":[86],"of":[87,135,169],"non-irradiated":[88,127],"ethosuximide.":[89],"Non-irradiated":[90],"extends":[92,130,145],"15\u00b0C":[96],"or":[97],"20\u00b0C,":[98],"but":[99],"25\u00b0C,":[102],"while":[103,126],"irradiated":[104,124],"shows":[106],"all":[110],"three":[111],"temperatures.":[112],"Dietary":[113],"restriction":[114,159],"bacterial":[116,161],"deprivation":[117,162],"does":[118],"protect":[120],"against":[121],"from":[123,157],"further":[129],"long":[132],"spans":[134],"restricted":[136],"animals.":[137],"These":[138],"data":[139],"support":[140],"model":[142],"mechanism":[150],"is,":[152],"least":[154],"partially,":[155],"distinct":[156],"dietary":[158],"demonstrates":[164],"an":[165],"unexpected":[166],"photochemical":[167],"conversion":[168],"toxic":[173],"light.":[177]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}