{"id":"https://openalex.org/W20023735","doi":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","title":"Exercise adaptation attenuates VEGF gene expression in human skeletal muscle","display_name":"Exercise adaptation attenuates VEGF gene expression in human skeletal muscle","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W20023735","doi":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","mag":"20023735","pmid":"https://pubmed.ncbi.nlm.nih.gov/10924077"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.2000.279.2.h772","doi":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082427940","display_name":"Russel S. Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. S. Richardson","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051741750","display_name":"Harrieth E. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Wagner","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059329645","display_name":"Sundar R. D. Mudaliar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. R. D. Mudaliar","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Saucedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Saucedo","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462483","display_name":"Robert R. Henry","orcid":"https://orcid.org/0000-0002-4821-0117","observed_orcids":["https://orcid.org/0000-0002-4821-0117"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Henry","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018377081","display_name":"Peter D. Wagner","orcid":"https://orcid.org/0000-0001-7957-7432","observed_orcids":["https://orcid.org/0000-0001-7957-7432"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. D. Wagner","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California 92093-0623"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California 92093-0623","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":15.0192,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.98684976,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"279","issue":"2","first_page":"H772","last_page":"H778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.824999988079071},{"id":"https://openalex.org/keywords/skeletal-muscle-angiogenesis","display_name":"skeletal muscle angiogenesis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/training-adaptation","display_name":"training effects","score":0.8690000176429749},{"id":"https://openalex.org/keywords/acute-exercise-response","display_name":"acute exercise response","score":0.7570000290870667},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.7329999804496765},{"id":"https://openalex.org/keywords/muscle-oxygen-consumption","display_name":"muscle oxygen consumption","score":0.9440000057220459},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7806782722473145},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7214438915252686},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.659581184387207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5823562741279602},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.569668173789978},{"id":"https://openalex.org/C2776643329","wikidata":"https://www.wikidata.org/wiki/Q975459","display_name":"Vastus lateralis muscle","level":3,"score":0.5404163002967834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4797155261039734},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.44548195600509644},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.43346524238586426},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.414014995098114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29884734749794006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13166537880897522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06419223546981812}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.2000.279.2.h772","doi":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2000.279.2.h772","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:10924077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10924077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3009436772","display_name":"PHYSIOLOGICAL CONSEQUENCES OF PULMONARY DISEASE","funder_award_id":"P01HL017731","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5654063860","display_name":null,"funder_award_id":"HL17731","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W12613825","https://openalex.org/W954944586","https://openalex.org/W1774496769","https://openalex.org/W1912211625","https://openalex.org/W1951334508","https://openalex.org/W1961157115","https://openalex.org/W1965616764","https://openalex.org/W1978495288","https://openalex.org/W1983763042","https://openalex.org/W1990470994","https://openalex.org/W1996073586","https://openalex.org/W2004886666","https://openalex.org/W2010848569","https://openalex.org/W2013509105","https://openalex.org/W2014669590","https://openalex.org/W2043863730","https://openalex.org/W2045655456","https://openalex.org/W2048249923","https://openalex.org/W2050862411","https://openalex.org/W2074243670","https://openalex.org/W2074922229","https://openalex.org/W2104525538","https://openalex.org/W2109393326","https://openalex.org/W2118655579","https://openalex.org/W2127980806","https://openalex.org/W2130449274","https://openalex.org/W2134812217","https://openalex.org/W2137609684","https://openalex.org/W2159120450","https://openalex.org/W2165485458","https://openalex.org/W2178693631","https://openalex.org/W2270876567","https://openalex.org/W2397447528","https://openalex.org/W2405350346","https://openalex.org/W2432048069","https://openalex.org/W3141488140"],"related_works":["https://openalex.org/W1984227938","https://openalex.org/W2002078289","https://openalex.org/W1774496769","https://openalex.org/W2119429444","https://openalex.org/W3175936356","https://openalex.org/W2130780675","https://openalex.org/W1967788538","https://openalex.org/W1995764547","https://openalex.org/W1968292332","https://openalex.org/W2155918372"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1,17,29,178],"a":[2,64,105,191],"component":[3],"of":[4,35,47,67,118],"the":[5,33,38,73,78,86,93,162,174],"multifactoral":[6],"adaptation":[7],"to":[8,158,187,190],"exercise":[9,39,75,145,160,196],"training,":[10],"and":[11,23,55,62,77,95,99,112,134,185],"vascular":[12],"endothelial":[13,24],"growth":[14],"factor":[15],"(VEGF)":[16],"involved":[18,179],"in":[19,37,53,92,104,108,116,161,180],"extracellular":[20],"matrix":[21],"changes":[22],"cell":[25],"proliferation.":[26],"However,":[27],"there":[28],"limited":[30],"evidence":[31],"supporting":[32],"role":[34],"VEGF":[36,177],"training":[40,79],"response.":[41],"Thus":[42],"we":[43],"studied":[44],"mRNA":[45,126,149,156],"levels":[46,127,150],"VEGF,":[48],"using":[49],"quantitative":[50],"Northern":[51],"analysis,":[52],"untrained":[54,94],"trained":[56,96,163],"human":[57],"skeletal":[58,182],"muscle":[59,89,109,121,141,183],"at":[60,90],"rest":[61,91],"after":[63,100,135],"single":[65],"bout":[66],"exercise.":[68,101],"Single":[69],"leg":[70],"knee-extension":[71],"provided":[72],"acute":[74,144,159],"stimulus":[76],"modality.":[80],"Four":[81],"biopsies":[82],"were":[83,128],"collected":[84],"from":[85],"vastus":[87],"lateralis":[88],"conditions":[97],"before":[98,130],"Training":[102],"resulted":[103],"35%":[106],"increase":[107,115],"oxygen":[110],"consumption":[111],"an":[113],"18%":[114],"number":[117],"capillaries":[119],"per":[120],"fiber.":[122],"At":[123],"rest,":[124],"VEGF/18S":[125,148,155],"similar":[129],"(0.38":[131],"+/-":[132,137,152,169],"0.04)":[133],"(1.2":[136],"0.4)":[138],"training.":[139],"When":[140],"was":[142,165],"untrained,":[143],"greatly":[146],"elevated":[147],"(16.9":[151],"6.7).":[153],"The":[154],"response":[157],"state":[164],"markedly":[166],"attenuated":[167],"(5.4":[168],"1.3).":[170],"These":[171],"data":[172],"support":[173],"concept":[175],"that":[176],"exercise-induced":[181],"angiogenesis":[184],"appears":[186],"be":[188],"subject":[189],"negative":[192],"feedback":[193],"mechanism":[194],"as":[195],"adaptations":[197],"occur.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
