{"id":"https://openalex.org/W2002373408","doi":"https://doi.org/10.1016/j.jalz.2011.05.564","title":"P1\u2010283: Mitochondrial DNA haplogroup, AD incidence, and cognitive function: The Cache County study on memory, health, and aging","display_name":"P1\u2010283: Mitochondrial DNA haplogroup, AD incidence, and cognitive function: The Cache County study on memory, health, and aging","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2002373408","doi":"https://doi.org/10.1016/j.jalz.2011.05.564","mag":"2002373408"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.564","doi":"https://doi.org/10.1016/j.jalz.2011.05.564","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.564","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.564","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.564","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107876646","display_name":"John S. K. Kauwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kauwe","raw_affiliation_strings":["Brigham Young University Provo Utah United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham Young University Provo Utah United States","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053243722","display_name":"Richard Cawthon","orcid":"https://orcid.org/0000-0001-6073-9112","observed_orcids":["https://orcid.org/0000-0001-6073-9112"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Cawthon","raw_affiliation_strings":["University of Utah, Salt Lake City, Utah United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, Utah United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071197369","display_name":"Richard A. Kerber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Kerber","raw_affiliation_strings":["University of Louisville, louisville, Kentucky, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, louisville, Kentucky, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026227665","display_name":"JoAnn T. Tschanz","orcid":"https://orcid.org/0000-0003-1766-2556","observed_orcids":["https://orcid.org/0000-0003-1766-2556"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JoAnn Tschanz","raw_affiliation_strings":["Utah State University, Logan, Utah United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utah State University, Logan, Utah United States","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102984796","display_name":"David C. Ward","orcid":"https://orcid.org/0000-0003-2380-4813","observed_orcids":["https://orcid.org/0000-0003-2380-4813","https://orcid.org/0000-0002-2705-408X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Ward","raw_affiliation_strings":["University of Hawaii, honolulu, Hawaii, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawaii, honolulu, Hawaii, United States","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023201995","display_name":"Maria C. Norton","orcid":"https://orcid.org/0000-0001-9261-6977","observed_orcids":["https://orcid.org/0000-0001-9261-6977"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Norton","raw_affiliation_strings":["Utah State University, Logan, Utah United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utah State University, Logan, Utah United States","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065109317","display_name":"Peter P. Zandi","orcid":"https://orcid.org/0000-0001-8423-2623","observed_orcids":["https://orcid.org/0000-0001-8423-2623"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Zandi","raw_affiliation_strings":["Johns Hopkins University, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001196482","display_name":"Kathleen Anne Welsh-Bohmer","orcid":"https://orcid.org/0000-0003-1824-0179","observed_orcids":["https://orcid.org/0000-0003-1824-0179"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Welsh\u2010Bohmer","raw_affiliation_strings":["Duke University, Durham, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057796570","display_name":"John C.S. Breitner","orcid":"https://orcid.org/0000-0003-4229-4687","observed_orcids":["https://orcid.org/0000-0003-4229-4687"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Breitner","raw_affiliation_strings":["McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028394515","display_name":"Ronald G. Munger","orcid":"https://orcid.org/0000-0002-2381-5355","observed_orcids":["https://orcid.org/0000-0002-2381-5355"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Munger","raw_affiliation_strings":["Utah State University, Logan, Utah United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utah State University, Logan, Utah United States","institution_ids":["https://openalex.org/I121980950"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14185419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/mitochondrial-haplogroups","display_name":"mtDNA haplogroups","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C201526758","wikidata":"https://www.wikidata.org/wiki/Q80686","display_name":"Haplogroup","level":5,"score":0.9196680188179016},{"id":"https://openalex.org/C78450430","wikidata":"https://www.wikidata.org/wiki/Q1356230","display_name":"Human mitochondrial DNA haplogroup","level":5,"score":0.6426237225532532},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6337164640426636},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5303968191146851},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5077048540115356},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.48452895879745483},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.465221643447876},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4619728624820709},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42522409558296204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38334596157073975},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.36584556102752686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35544490814208984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3510574698448181},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30929890275001526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23925629258155823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07122141122817993},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.564","doi":"https://doi.org/10.1016/j.jalz.2011.05.564","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.564","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.564","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2011.05.564","doi":"https://doi.org/10.1016/j.jalz.2011.05.564","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.564","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.564","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002373408.pdf","grobid_xml":"https://content.openalex.org/works/W2002373408.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097171620","https://openalex.org/W2042141031","https://openalex.org/W4312086198","https://openalex.org/W4200455181","https://openalex.org/W4290794105","https://openalex.org/W3034246445","https://openalex.org/W2040979033","https://openalex.org/W2037581579","https://openalex.org/W2009756075","https://openalex.org/W2081616997"],"abstract_inverted_index":{"Previous":[0],"findings":[1],"from":[2,71,95,111],"case-control":[3],"studies":[4],"of":[5,33,52,83,88,146,153,304,308,321,344],"Alzheimer's":[6],"disease":[7],"(AD)":[8],"and":[9,57,128,151,163,197,223,233,254,280,294,327,331],"mitochondrial":[10],"DNA":[11],"(mtDNA)":[12],"haplogroup":[13,29,56,147,253,326],"have":[14],"identified":[15],"some":[16,24],"significant":[17,249,267,340],"associations,":[18],"including":[19,123],"higher":[20],"AD":[21,34,44,58,167,228,329],"risk":[22,229],"among":[23],"populations":[25],"for":[26,64,100,158,166],"individuals":[27,82,104,275],"in":[28,36,184,189,192,195,199,219,270,273,289],"H.":[30],"Further":[31],"examination":[32],"incidence":[35,330],"tandem":[37],"with":[38,133,177,208,342],"quantitative":[39],"cognitive":[40,309,333,345],"phenotypes":[41],"leading":[42],"to":[43,48,210,231,291],"onset":[45],"may":[46],"help":[47],"refine":[49],"our":[50],"understanding":[51],"the":[53,72,101,112,134,144,174,185,292,302],"relationship":[54],"between":[55,206,251,324],"risk.":[59],"mtDNA":[60,91,119,179,252,325],"haplogroups":[61,120,207,220,296],"were":[62,93,105,121,182,202,311],"determined":[63,110],"1009":[65],"persons":[66,176],"without":[67],"dementia":[68],"at":[69],"baseline":[70,255],"Cache":[73],"County":[74],"Memory":[75],"Study":[76],"cohort,":[77],"comprised":[78],"almost":[79],"entirely":[80],"by":[81],"European":[84],"ancestry.":[85],"For":[86],"284":[87],"these":[89],"subjects,":[90],"sequences":[92],"typed":[94],"stored":[96],"blood":[97],"samples.":[98],"Haplogroups":[99],"remaining":[102],"768":[103],"imputed":[106],"based":[107],"on":[108,148],"matrilineages":[109],"Utah":[113],"Population":[114],"Database":[115],"(UPDB).":[116],"Five":[117],"major":[118],"identified,":[122],"H,":[124,221,278],"UK,":[125,193],"WIX,":[126],"U,":[127],"JT.":[129],"Cognition":[130],"was":[131,168,246,319,337],"assessed":[132,169],"Modified":[135],"Mini-Mental":[136],"State":[137],"Exam":[138],"(3MS).":[139],"Linear":[140],"mixed":[141,263],"models":[142],"examined":[143],"effects":[145],"average":[149,271,332],"3MS":[150,154,256,272,285],"rate":[152,343],"decline,":[155],"controlling":[156],"also":[157],"APOE":[159,213],"genotype,":[160,214],"age,":[161,212],"gender,":[162,211],"education.":[164],"Risk":[165],"using":[170],"logistic":[171],"regression.":[172],"Of":[173],"968":[175],"available":[178],"data,":[180],"45.0%":[181],"classified":[183,276],"H":[186],"haplogroup,":[187],"22.1%":[188],"JT,":[190,222,279],"23.9%":[191],"4.0%":[194],"V,":[196],"5.0%":[198],"WIX.":[200],"There":[201,245],"no":[203],"significance":[204],"differences":[205,269],"respect":[209],"or":[215],"education":[216],"level.":[217],"Individuals":[218],"WIX":[224,281],"had":[225,282],"significantly":[226,283,313],"greater":[227],"relative":[230],"UK":[232,293],"V":[234,295],"(OR":[235],"=":[236,240,243,258,298],"1.97,":[237],"95%":[238],"CI":[239],"(1.07,3.66),":[241],"p":[242],"0.04).":[244],"additionally":[247],"a":[248,339],"association":[250,323,341],"(p":[257,297],"0.02).":[259],"In":[260,315],"adjusted":[261],"linear":[262],"models,":[264],"we":[265],"found":[266],"overall":[268],"that":[274],"as":[277],"lower":[284],"scores":[286],"over":[287,301],"time":[288],"comparison":[290],"0.04),":[299],"although":[300,335],"course":[303],"study":[305],"their":[306],"rates":[307],"decline":[310],"not":[312,338],"different.":[314],"this":[316],"sample,":[317],"there":[318,336],"evidence":[320],"an":[322],"both":[328],"function,":[334],"change.":[346]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
