{"id":"https://openalex.org/W2002355872","doi":"https://doi.org/10.1016/0065-2571(91)90017-g","title":"Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system","display_name":"Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2002355872","doi":"https://doi.org/10.1016/0065-2571(91)90017-g","mag":"2002355872","pmid":"https://pubmed.ncbi.nlm.nih.gov/1877390"},"language":"en","primary_location":{"id":"doi:10.1016/0065-2571(91)90017-g","doi":"https://doi.org/10.1016/0065-2571(91)90017-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0065-2571(91)90017-g","pdf_url":null,"source":{"id":"https://openalex.org/S4210167908","display_name":"Advances in Enzyme Regulation","issn_l":"0065-2571","issn":["0065-2571","1873-2437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Enzyme Regulation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077265250","display_name":"Bernardo Nadal\u2010Ginard","orcid":"https://orcid.org/0000-0002-1197-3612","observed_orcids":["https://orcid.org/0000-0002-1197-3612"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernardo Nadal-Ginard","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022055324","display_name":"Christopher W. J. Smith","orcid":"https://orcid.org/0000-0002-2753-3398","observed_orcids":["https://orcid.org/0000-0002-2753-3398"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W.J. Smith","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038115749","display_name":"James G. Patton","orcid":"https://orcid.org/0000-0001-5749-0870","observed_orcids":["https://orcid.org/0000-0001-5749-0870"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Patton","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113705523","display_name":"Roger E. Breitbart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger E. Breitbart","raw_affiliation_strings":["Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Laboratory of Cellular and Molecular Cardiology, Department of Cardiology, Children's Hospital, Departments of Cellular and Molecular Physiology, and Pediatrics, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4746,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.51528777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"31","issue":null,"first_page":"261","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":1.0},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.8949999809265137},{"id":"https://openalex.org/keywords/contractile-proteins","display_name":"contractile proteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alpha-tropomyosin","display_name":"alpha-tropomyosin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/troponin-t","display_name":"troponin T","score":0.8999999761581421},{"id":"https://openalex.org/keywords/muscle-cells","display_name":"muscle cells","score":0.5860000252723694},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.751676619052887},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6763239502906799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6391181945800781},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6016653180122375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5780355930328369},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5121190547943115},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5116577744483948},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.47114697098731995},{"id":"https://openalex.org/C205875245","wikidata":"https://www.wikidata.org/wiki/Q418454","display_name":"Tropomyosin","level":3,"score":0.4399494230747223},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.4394806921482086},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4339072108268738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3353006839752197},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.1383287012577057},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10503199696540833}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003285","descriptor_name":"Contractile Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014336","descriptor_name":"Troponin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0065-2571(91)90017-g","doi":"https://doi.org/10.1016/0065-2571(91)90017-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0065-2571(91)90017-g","pdf_url":null,"source":{"id":"https://openalex.org/S4210167908","display_name":"Advances in Enzyme Regulation","issn_l":"0065-2571","issn":["0065-2571","1873-2437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Enzyme Regulation","raw_type":"journal-article"},{"id":"pmid:1877390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1877390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in enzyme regulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W8823967","https://openalex.org/W189799969","https://openalex.org/W1486144458","https://openalex.org/W1492798688","https://openalex.org/W1503786179","https://openalex.org/W1515802281","https://openalex.org/W1518630967","https://openalex.org/W1530353793","https://openalex.org/W1531986635","https://openalex.org/W1573549078","https://openalex.org/W1583928970","https://openalex.org/W1584311881","https://openalex.org/W1597808722","https://openalex.org/W1603479071","https://openalex.org/W1799462851","https://openalex.org/W1836955960","https://openalex.org/W1864764602","https://openalex.org/W1905789932","https://openalex.org/W1917300031","https://openalex.org/W1947900728","https://openalex.org/W1965051773","https://openalex.org/W1967209412","https://openalex.org/W1976963104","https://openalex.org/W1983271049","https://openalex.org/W1986574046","https://openalex.org/W1989077450","https://openalex.org/W1989109522","https://openalex.org/W1989482194","https://openalex.org/W1989996631","https://openalex.org/W1994970453","https://openalex.org/W2003213264","https://openalex.org/W2008422577","https://openalex.org/W2008932218","https://openalex.org/W2013014592","https://openalex.org/W2013836961","https://openalex.org/W2014791263","https://openalex.org/W2015221277","https://openalex.org/W2015252183","https://openalex.org/W2024588724","https://openalex.org/W2032405270","https://openalex.org/W2033917643","https://openalex.org/W2039762550","https://openalex.org/W2042006657","https://openalex.org/W2044147175","https://openalex.org/W2044863269","https://openalex.org/W2045984686","https://openalex.org/W2047557186","https://openalex.org/W2047615149","https://openalex.org/W2050710651","https://openalex.org/W2051783923","https://openalex.org/W2054123210","https://openalex.org/W2055651252","https://openalex.org/W2057479447","https://openalex.org/W2060578134","https://openalex.org/W2061820742","https://openalex.org/W2065983662","https://openalex.org/W2066843250","https://openalex.org/W2071971601","https://openalex.org/W2072229642","https://openalex.org/W2076944748","https://openalex.org/W2081561538","https://openalex.org/W2085785668","https://openalex.org/W2089531735","https://openalex.org/W2089796770","https://openalex.org/W2092991423","https://openalex.org/W2094038629","https://openalex.org/W2094271838","https://openalex.org/W2112511379","https://openalex.org/W2112590565","https://openalex.org/W2114992132","https://openalex.org/W2118189700","https://openalex.org/W2121989806","https://openalex.org/W2125959590","https://openalex.org/W2133143001","https://openalex.org/W2140872205","https://openalex.org/W2143944785","https://openalex.org/W2145761775","https://openalex.org/W2149393914","https://openalex.org/W2149787772","https://openalex.org/W2170255408","https://openalex.org/W2170266703","https://openalex.org/W2177366650","https://openalex.org/W2210986612","https://openalex.org/W2339353415","https://openalex.org/W2342862502","https://openalex.org/W3021597811","https://openalex.org/W4254469900","https://openalex.org/W4300539875"],"related_works":["https://openalex.org/W53954117","https://openalex.org/W2094038629","https://openalex.org/W234632681","https://openalex.org/W2083826592","https://openalex.org/W4248389285","https://openalex.org/W2149393914","https://openalex.org/W5583878","https://openalex.org/W2085785668","https://openalex.org/W6977587662","https://openalex.org/W2143326261"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}