{"id":"https://openalex.org/W2002315548","doi":"https://doi.org/10.1210/me.2007-0426","title":"Androgen Receptor-Mediated Apoptosis Is Regulated by Photoactivatable Androgen Receptor Ligands","display_name":"Androgen Receptor-Mediated Apoptosis Is Regulated by Photoactivatable Androgen Receptor Ligands","publication_year":2008,"publication_date":"2008-06-19","ids":{"openalex":"https://openalex.org/W2002315548","doi":"https://doi.org/10.1210/me.2007-0426","mag":"2002315548","pmid":"https://pubmed.ncbi.nlm.nih.gov/18562628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2631375"},"language":"en","primary_location":{"id":"doi:10.1210/me.2007-0426","doi":"https://doi.org/10.1210/me.2007-0426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2007-0426","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2631375","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030976585","display_name":"Boris Risek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Risek","raw_affiliation_strings":["Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, III T.W. Alexander Drive, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, III T.W. Alexander Drive, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066234326","display_name":"Piotr J. Bilski","orcid":"https://orcid.org/0000-0002-6375-805X","observed_orcids":["https://orcid.org/0000-0002-6375-805X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Bilski","raw_affiliation_strings":["Laboratory of Pharmacology and Chemistry (P.B.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Chemistry (P.B.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050866443","display_name":"Annette B. Rice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annette B. Rice","raw_affiliation_strings":["Laboratory of Reproductive and Developmental Toxicology (B.R., A.B.R., W.T.S.), Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Reproductive and Developmental Toxicology (B.R., A.B.R., W.T.S.), Research Triangle Park, North Carolina 27709","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108385950","display_name":"William T. Schrader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William T. Schrader","raw_affiliation_strings":["Laboratory of Reproductive and Developmental Toxicology (B.R., A.B.R., W.T.S.), Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Reproductive and Developmental Toxicology (B.R., A.B.R., W.T.S.), Research Triangle Park, North Carolina 27709","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108385950"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.532,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83742212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"9","first_page":"2099","last_page":"2115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.24819999933242798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/photoactivatable-ligands","display_name":"photoactivatable ligands","score":0.9269999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.7480000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.734000027179718},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.7329999804496765},{"id":"https://openalex.org/keywords/prostate-cancer-cells","display_name":"prostate cancer cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/caspase-inhibition","display_name":"caspase inhibition","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bystander-effect","display_name":"bystander effect","score":0.7990000247955322},{"id":"https://openalex.org/keywords/r1881","display_name":"R1881","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.9066420793533325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8010332584381104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5745234489440918},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5403227806091309},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5340235233306885},{"id":"https://openalex.org/C138599941","wikidata":"https://www.wikidata.org/wiki/Q18031158","display_name":"RNF4","level":5,"score":0.4772074818611145},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4350340664386749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4160214364528656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25600337982177734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22426959872245789},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.11900219321250916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1099041998386383},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06108394265174866}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015741","descriptor_name":"Metribolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015741","descriptor_name":"Metribolone","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018462","descriptor_name":"Photobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/me.2007-0426","doi":"https://doi.org/10.1210/me.2007-0426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2007-0426","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2631375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2631375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},{"id":"pmid:18562628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18562628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2631375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2631375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1447670574","display_name":"Biology of Non-steroidal Androgen Receptor Modulators","funder_award_id":"Z01ES101985","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W38078248","https://openalex.org/W1419228847","https://openalex.org/W1502076440","https://openalex.org/W1862557020","https://openalex.org/W1967932707","https://openalex.org/W1968577485","https://openalex.org/W1982647833","https://openalex.org/W1987409548","https://openalex.org/W1998893258","https://openalex.org/W2003958312","https://openalex.org/W2011094327","https://openalex.org/W2015620666","https://openalex.org/W2021565484","https://openalex.org/W2025312106","https://openalex.org/W2035396203","https://openalex.org/W2038265619","https://openalex.org/W2047860376","https://openalex.org/W2052853635","https://openalex.org/W2053258455","https://openalex.org/W2058273161","https://openalex.org/W2059968629","https://openalex.org/W2060046004","https://openalex.org/W2060232277","https://openalex.org/W2060943196","https://openalex.org/W2061530358","https://openalex.org/W2061686178","https://openalex.org/W2062273647","https://openalex.org/W2063477993","https://openalex.org/W2066570340","https://openalex.org/W2072210156","https://openalex.org/W2077935465","https://openalex.org/W2078954239","https://openalex.org/W2084647824","https://openalex.org/W2089091268","https://openalex.org/W2089976500","https://openalex.org/W2090257664","https://openalex.org/W2093978777","https://openalex.org/W2095348706","https://openalex.org/W2115151855","https://openalex.org/W2123996585","https://openalex.org/W2128016380","https://openalex.org/W2128840922","https://openalex.org/W2129340606","https://openalex.org/W2134259738","https://openalex.org/W2138297556","https://openalex.org/W2144941480","https://openalex.org/W2145846248","https://openalex.org/W2151922331","https://openalex.org/W2157723631","https://openalex.org/W2160534562","https://openalex.org/W2164698768","https://openalex.org/W2169777638","https://openalex.org/W2170843919","https://openalex.org/W2340799873"],"related_works":["https://openalex.org/W2009854256","https://openalex.org/W7098906149","https://openalex.org/W2147712254","https://openalex.org/W2123996585","https://openalex.org/W2515777381","https://openalex.org/W2084647824","https://openalex.org/W2397633070","https://openalex.org/W4366975073","https://openalex.org/W2329018521","https://openalex.org/W1990241243"],"abstract_inverted_index":{"We":[0],"have":[1,12],"studied":[2],"nonsteroidal":[3],"ligands":[4,205],"of":[5,43,85,111,130,166,174,177,181,199,214],"the":[6,56,75,79,117,134,167],"human":[7,47],"androgen":[8],"receptor":[9],"(hAR)":[10],"and":[11,132,153],"shown":[13],"elsewhere":[14],"that":[15],"when":[16,78],"photoactivated":[17],"by":[18,147,164,194],"visible":[19],"light":[20,39],"they":[21],"collide":[22],"with":[23],"O2":[24],"to":[25,120],"yield":[26],"singlet":[27],"oxygens":[28],"(1O2)":[29],"in":[30,46,179],"vitro.":[31],"Here":[32],"we":[33],"report":[34],"cell":[35],"killing":[36],"after":[37],"brief":[38],"activation":[40],"(405":[41],"nm)":[42],"1,2,3,4-tetrahydro-2,2-dimethyl-6-(trifluoromethyl)-8-pyridono[5,6-g]quinoline":[44],"(TDPQ)":[45],"prostate":[48],"tumor":[49],"cells.":[50],"TDPQ/AR":[51],"complexes":[52],"were":[53,63,69,81,124],"required":[54],"for":[55,212],"death":[57,141],"response":[58],"because":[59,160],"AR-positive":[60],"LNCaP":[61,94],"cells":[62,68,86,115,118,183,193,215],"killed,":[64],"whereas":[65],"AR-negative":[66],"PC-3":[67,114],"resistant.":[70],"Excess":[71],"dihydrotestosterone":[72],"(DHT)":[73],"blocked":[74],"TDPQ":[76],"effect":[77],"two":[80],"added":[82],"together;":[83],"irradiation":[84],"containing":[87],"DHT":[88],"alone":[89],"had":[90],"no":[91],"effect.":[92,202],"When":[93],"AR":[95,137],"expression":[96],"was":[97,106,162],"suppressed":[98],"using":[99,126],"small":[100],"interfering":[101],"oligonucleotides":[102],"targeting":[103],"AR,":[104],"photocytotoxicity":[105],"diminished.":[107],"Conversely,":[108],"stable":[109],"transfection":[110],"hAR":[112],"into":[113,190],"made":[116],"photosensitive":[119],"TDPQ.":[121],"Similar":[122],"results":[123],"obtained":[125],"a":[127,200,209],"structural":[128],"isomer":[129],"TDPQ,":[131],"also":[133],"synthetic":[135],"steroidal":[136],"ligand":[138],"R1881.":[139],"Cell":[140],"occurred":[142],"via":[143],"apoptosis":[144],"as":[145],"demonstrated":[146],"annexin":[148],"V":[149],"immunostaining,":[150],"nuclear":[151,218],"condensation,":[152],"caspase":[154],"inhibition.":[155],"Death":[156],"involved":[157],"oxidative":[158,185],"stress,":[159],"it":[161],"prevented":[163],"addition":[165],"antioxidant":[168],"ascorbic":[169],"acid":[170],"during":[171],"photoactivation.":[172],"Detection":[173],"elevated":[175],"levels":[176],"8-hydroxy-2'-deoxyguanosine":[178],"nuclei":[180],"irradiated":[182],"indicated":[184],"DNA":[186],"damage.":[187],"Apoptosis":[188],"spread":[189],"adjacent":[191],"nonirradiated":[192],"direct":[195],"cell-cell":[196],"contacts,":[197],"indicative":[198],"bystander":[201],"Other":[203],"photoactivatable":[204],"are":[206],"described,":[207],"implying":[208],"general":[210],"method":[211],"ablation":[213],"bearing":[216],"specific":[217],"hormone":[219],"receptors.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}