{"id":"https://openalex.org/W2002308570","doi":"https://doi.org/10.1016/j.bbcan.2014.01.004","title":"Tumor-induced perturbations of cytokines and immune cell networks","display_name":"Tumor-induced perturbations of cytokines and immune cell networks","publication_year":2014,"publication_date":"2014-01-16","ids":{"openalex":"https://openalex.org/W2002308570","doi":"https://doi.org/10.1016/j.bbcan.2014.01.004","mag":"2002308570","pmid":"https://pubmed.ncbi.nlm.nih.gov/24440852"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbcan.2014.01.004","doi":"https://doi.org/10.1016/j.bbcan.2014.01.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2014.01.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0304419X14000110/pdf","source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0304419X14000110/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048172000","display_name":"Brett Burkholder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Burkholder","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","institution_ids":["https://openalex.org/I4210123277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015981584","display_name":"Ren-Yu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ren-Yu Huang","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015981584","display_name":"Ren-Yu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ren-Yu Huang","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","RayBiotech, Inc., Guangzhou 510600, China","RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]},{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","institution_ids":["https://openalex.org/I4210123277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042674101","display_name":"Rob Burgess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Rob Burgess","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","institution_ids":["https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101915487","display_name":"Shuhong Luo","orcid":"https://orcid.org/0000-0002-9058-4833","observed_orcids":["https://orcid.org/0000-0002-9058-4833"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shuhong Luo","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China","RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","institution_ids":["https://openalex.org/I4210123277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070393024","display_name":"Valerie Sloane Jones","orcid":"https://orcid.org/0000-0002-4204-9959","observed_orcids":["https://orcid.org/0000-0002-4204-9959"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Valerie Sloane Jones","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA","institution_ids":["https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101905420","display_name":"Wenji Zhang","orcid":"https://orcid.org/0000-0003-1500-6627","observed_orcids":["https://orcid.org/0000-0003-1500-6627"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenji Zhang","raw_affiliation_strings":["RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034202621","display_name":"Zongqiang Lv","orcid":"https://orcid.org/0009-0000-2340-9392","observed_orcids":["https://orcid.org/0009-0000-2340-9392"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Qiang Lv","raw_affiliation_strings":["RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102290475","display_name":"Changyu Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Yu Gao","raw_affiliation_strings":["RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bao-Ling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Ling Wang","raw_affiliation_strings":["RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590788","display_name":"Yuming Zhang","orcid":"https://orcid.org/0009-0007-9710-7726","observed_orcids":["https://orcid.org/0009-0007-9710-7726"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yu-Ming Zhang","raw_affiliation_strings":["RayBiotech, Inc., Guangzhou 510600, China","RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]},{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077630778","display_name":"Ruo\u2010Pan Huang","orcid":"https://orcid.org/0000-0002-5884-8026","observed_orcids":["https://orcid.org/0000-0002-5884-8026"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ruo-Pan Huang","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077630778","display_name":"Ruo\u2010Pan Huang","orcid":"https://orcid.org/0000-0002-5884-8026","observed_orcids":["https://orcid.org/0000-0002-5884-8026"]},"institutions":[{"id":"https://openalex.org/I4210116455","display_name":"RayBiotech (China)","ror":"https://ror.org/026djmp70","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"id":"https://openalex.org/I4210123277","display_name":"RayBiotech (United States)","ror":"https://ror.org/02319f413","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123277"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ruo-Pan Huang","raw_affiliation_strings":["RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","RayBiotech, Inc., Guangzhou 510600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RayBiotech, Inc., 3607 Parkway Lane, Suite 100, Norcross, GA 30092, USA; RayBiotech, Inc., Guangzhou 510600, China; South China Biochip Research Center, Guangzhou 510630, China. Electronic address: rhuang@raybiotech.com","institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"]},{"raw_affiliation_string":"RayBiotech, Inc., Guangzhou 510600, China","institution_ids":["https://openalex.org/I4210116455"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015981584","https://openalex.org/A5077630778"],"corresponding_institution_ids":["https://openalex.org/I4210116455","https://openalex.org/I4210123277"],"apc_list":{"value":5070,"currency":"USD","value_usd":5070},"apc_paid":{"value":5070,"currency":"USD","value_usd":5070},"fwci":14.2133,"has_fulltext":true,"cited_by_count":357,"citation_normalized_percentile":{"value":0.99444607,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"1845","issue":"2","first_page":"182","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.21070000529289246,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8289999961853027},{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.8489999771118164},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunoediting","display_name":"immunoediting","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-escape","display_name":"tumor escape","score":0.39399999380111694},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6923235654830933},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47595998644828796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3723728060722351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3686462938785553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35238391160964966},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32344603538513184}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015166","descriptor_name":"Monitoring, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015166","descriptor_name":"Monitoring, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015166","descriptor_name":"Monitoring, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbcan.2014.01.004","doi":"https://doi.org/10.1016/j.bbcan.2014.01.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2014.01.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0304419X14000110/pdf","source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},{"id":"pmid:24440852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24440852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbcan.2014.01.004","doi":"https://doi.org/10.1016/j.bbcan.2014.01.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2014.01.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0304419X14000110/pdf","source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2077358701","display_name":null,"funder_award_id":"2012B090600021","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G4501370094","display_name":null,"funder_award_id":"2012Q-P182","funder_id":"https://openalex.org/F4320333334","funder_display_name":"Guangdong Province Introduction of Innovative R&D Team"},{"id":"https://openalex.org/G8742073286","display_name":null,"funder_award_id":"201001s0104659419","funder_id":"https://openalex.org/F4320333334","funder_display_name":"Guangdong Province Introduction of Innovative R&D Team"}],"funders":[{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320333334","display_name":"Guangdong Province Introduction of Innovative R&D Team","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002308570.pdf","grobid_xml":"https://content.openalex.org/works/W2002308570.grobid-xml"},"referenced_works_count":177,"referenced_works":["https://openalex.org/W118325993","https://openalex.org/W1219680990","https://openalex.org/W1480357432","https://openalex.org/W1490379819","https://openalex.org/W1500831029","https://openalex.org/W1511743510","https://openalex.org/W1515725948","https://openalex.org/W1518759830","https://openalex.org/W1527752391","https://openalex.org/W1537143297","https://openalex.org/W1571546772","https://openalex.org/W1661544713","https://openalex.org/W1859257957","https://openalex.org/W1967060514","https://openalex.org/W1967884480","https://openalex.org/W1967890713","https://openalex.org/W1975568557","https://openalex.org/W1983560795","https://openalex.org/W1984162437","https://openalex.org/W1984186890","https://openalex.org/W1984484036","https://openalex.org/W1984504267","https://openalex.org/W1984706590","https://openalex.org/W1986058292","https://openalex.org/W1988881559","https://openalex.org/W1988924112","https://openalex.org/W1989595767","https://openalex.org/W1990587639","https://openalex.org/W1992112921","https://openalex.org/W1993820570","https://openalex.org/W1994625040","https://openalex.org/W1995481385","https://openalex.org/W1995658981","https://openalex.org/W1997605269","https://openalex.org/W2001131198","https://openalex.org/W2002157461","https://openalex.org/W2004630197","https://openalex.org/W2006252261","https://openalex.org/W2012097777","https://openalex.org/W2012704834","https://openalex.org/W2013411992","https://openalex.org/W2014073110","https://openalex.org/W2018867485","https://openalex.org/W2021226726","https://openalex.org/W2021580329","https://openalex.org/W2026318599","https://openalex.org/W2028240889","https://openalex.org/W2028554313","https://openalex.org/W2029650614","https://openalex.org/W2029695719","https://openalex.org/W2031576122","https://openalex.org/W2037550429","https://openalex.org/W2039146285","https://openalex.org/W2041600831","https://openalex.org/W2042355069","https://openalex.org/W2043776488","https://openalex.org/W2046972425","https://openalex.org/W2047479954","https://openalex.org/W2047900555","https://openalex.org/W2049029511","https://openalex.org/W2049491375","https://openalex.org/W2049528074","https://openalex.org/W2049822454","https://openalex.org/W2049856484","https://openalex.org/W2050941607","https://openalex.org/W2051099402","https://openalex.org/W2052313621","https://openalex.org/W2053277543","https://openalex.org/W2056063027","https://openalex.org/W2058648826","https://openalex.org/W2061217549","https://openalex.org/W2062627337","https://openalex.org/W2064304633","https://openalex.org/W2064920472","https://openalex.org/W2065385505","https://openalex.org/W2067885308","https://openalex.org/W2068005505","https://openalex.org/W2068994108","https://openalex.org/W2069200323","https://openalex.org/W2073218792","https://openalex.org/W2073606915","https://openalex.org/W2076866768","https://openalex.org/W2078323166","https://openalex.org/W2079663505","https://openalex.org/W2080641261","https://openalex.org/W2083991703","https://openalex.org/W2084414513","https://openalex.org/W2084599508","https://openalex.org/W2088571368","https://openalex.org/W2089828715","https://openalex.org/W2092355198","https://openalex.org/W2093424661","https://openalex.org/W2093660938","https://openalex.org/W2095138364","https://openalex.org/W2096625946","https://openalex.org/W2096826039","https://openalex.org/W2098005365","https://openalex.org/W2098506409","https://openalex.org/W2099117852","https://openalex.org/W2100510996","https://openalex.org/W2102152192","https://openalex.org/W2103513989","https://openalex.org/W2105212193","https://openalex.org/W2105709966","https://openalex.org/W2106943429","https://openalex.org/W2107079238","https://openalex.org/W2109721791","https://openalex.org/W2110845079","https://openalex.org/W2111713436","https://openalex.org/W2114027214","https://openalex.org/W2114050989","https://openalex.org/W2115407830","https://openalex.org/W2115536507","https://openalex.org/W2116291089","https://openalex.org/W2116378201","https://openalex.org/W2117692326","https://openalex.org/W2118278569","https://openalex.org/W2120620347","https://openalex.org/W2120692790","https://openalex.org/W2121052443","https://openalex.org/W2123105952","https://openalex.org/W2123124042","https://openalex.org/W2123900004","https://openalex.org/W2126615361","https://openalex.org/W2127421703","https://openalex.org/W2128319428","https://openalex.org/W2128967324","https://openalex.org/W2130229338","https://openalex.org/W2130354176","https://openalex.org/W2130870648","https://openalex.org/W2131610923","https://openalex.org/W2134139967","https://openalex.org/W2138128450","https://openalex.org/W2140521865","https://openalex.org/W2142357559","https://openalex.org/W2144114922","https://openalex.org/W2146708145","https://openalex.org/W2147087574","https://openalex.org/W2148576689","https://openalex.org/W2150633526","https://openalex.org/W2150678612","https://openalex.org/W2151327646","https://openalex.org/W2152155935","https://openalex.org/W2157207652","https://openalex.org/W2157269800","https://openalex.org/W2157962067","https://openalex.org/W2159181129","https://openalex.org/W2162819001","https://openalex.org/W2163825883","https://openalex.org/W2164355106","https://openalex.org/W2164618834","https://openalex.org/W2165639314","https://openalex.org/W2166530259","https://openalex.org/W2167447755","https://openalex.org/W2168631000","https://openalex.org/W2169820627","https://openalex.org/W2170931646","https://openalex.org/W2171481006","https://openalex.org/W2171831396","https://openalex.org/W2171998177","https://openalex.org/W2173547083","https://openalex.org/W2208115725","https://openalex.org/W2314818675","https://openalex.org/W2416811803","https://openalex.org/W2491842184","https://openalex.org/W2593611879","https://openalex.org/W2783142245","https://openalex.org/W3127074869","https://openalex.org/W4240703051","https://openalex.org/W4256189622","https://openalex.org/W4313308240","https://openalex.org/W6629414752","https://openalex.org/W6663128759","https://openalex.org/W6674896819","https://openalex.org/W6675535923","https://openalex.org/W6677498071","https://openalex.org/W6677653775"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Until":[0],"recently,":[1],"the":[2,11,18,29,57,89,134,145,182,200],"intrinsically":[3],"high":[4],"level":[5],"of":[6,13,21,31,65,69,80,83,94,126,174,195,202],"cross-talk":[7],"between":[8],"immune":[9,14,41,127,139],"cells,":[10],"complexity":[12],"cell":[15,86,128,140],"development,":[16],"and":[17,39,85,98,122,138,164,198],"pleiotropic":[19],"nature":[20],"cytokine":[22,58,95,110,147,187],"signaling":[23,54],"have":[24,102,189],"hampered":[25],"progress":[26],"in":[27,73,157,181],"understanding":[28,194,204],"mechanisms":[30],"immunosuppression":[32],"by":[33,115,119,166],"which":[34,61],"tumor":[35,116,183],"cells":[36,117,121],"circumvent":[37],"native":[38],"adaptive":[40],"responses.":[42],"One":[43],"technology":[44],"that":[45,107,149],"has":[46],"helped":[47],"to":[48,67,154,162,191,205],"shed":[49],"light":[50],"on":[51],"this":[52,203],"complex":[53,74,105],"network":[55],"is":[56],"antibody":[59,96],"array,":[60],"facilitates":[62],"simultaneous":[63],"screening":[64,92],"dozens":[66],"hundreds":[68],"secreted":[70,177],"signal":[71,179],"proteins":[72],"biological":[75],"samples.":[76],"The":[77],"combined":[78],"applications":[79],"traditional":[81],"methods":[82],"molecular":[84],"biology":[87],"with":[88,186],"high-content,":[90],"high-throughput":[91],"capabilities":[93],"arrays":[97],"other":[99],"multiplexed":[100],"immunoassays":[101],"revealed":[103],"a":[104,123,158],"mechanism":[106],"involves":[108],"multiple":[109],"signals":[111,148],"contributed":[112,190],"not":[113],"just":[114],"but":[118],"stromal":[120],"wide":[124],"spectrum":[125],"types.":[129],"This":[130],"review":[131],"will":[132,171],"summarize":[133],"interactions":[135],"among":[136],"cancerous":[137],"types,":[141],"as":[142,144],"well":[143],"key":[146],"are":[150],"required":[151],"for":[152],"tumors":[153],"survive":[155],"immunoediting":[156],"dormant":[159],"state":[160],"or":[161],"grow":[163],"spread":[165],"escaping":[167],"it.":[168],"Additionally,":[169],"it":[170],"present":[172],"examples":[173],"how":[175],"probing":[176],"cell-cell":[178],"networks":[180],"microenvironment":[184],"(TME)":[185],"screens":[188],"our":[192],"current":[193],"these":[196],"processes":[197],"discuss":[199],"implications":[201],"antitumor":[206],"therapies.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":42},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":39},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":8}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}