{"id":"https://openalex.org/W2002306705","doi":"https://doi.org/10.1158/1538-7445.nonrna12-a7","title":"Abstract A7: Roles of miRNAs in the switch of TGF-\u03b2 from tumor suppressor to pro-oncogenic factor in cancer progression","display_name":"Abstract A7: Roles of miRNAs in the switch of TGF-\u03b2 from tumor suppressor to pro-oncogenic factor in cancer progression","publication_year":2012,"publication_date":"2012-01-08","ids":{"openalex":"https://openalex.org/W2002306705","doi":"https://doi.org/10.1158/1538-7445.nonrna12-a7","mag":"2002306705"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.nonrna12-a7","doi":"https://doi.org/10.1158/1538-7445.nonrna12-a7","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.nonrna12-a7","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112686872","display_name":"Yoshiko Nagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshiko Nagano","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD","National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055646675","display_name":"Maxwell P. Lee","orcid":"https://orcid.org/0000-0003-3738-1292","observed_orcids":["https://orcid.org/0000-0003-3738-1292"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell P. Lee","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD","National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053646631","display_name":"Lalage M. Wakefield","orcid":"https://orcid.org/0000-0003-4124-5250","observed_orcids":["https://orcid.org/0000-0003-4124-5250"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lalage M. Wakefield","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD","National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"2_Supplement","first_page":"A7","last_page":"A7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.23890000581741333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7419999837875366},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/breast-cancer-progression","display_name":"breast cancer progression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/let-7i","display_name":"let-7i","score":0.8309999704360962},{"id":"https://openalex.org/keywords/let-7g","display_name":"let-7g","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5249999761581421},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.718999981880188},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7477474808692932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6485096216201782},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6436659693717957},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.608802080154419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6070013642311096},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5916441679000854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5699435472488403},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5611453056335449},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5196232199668884},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4805462956428528},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.41096267104148865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2741461992263794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1869262158870697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1707438826560974}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.nonrna12-a7","doi":"https://doi.org/10.1158/1538-7445.nonrna12-a7","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.nonrna12-a7","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009548550","https://openalex.org/W3032589310","https://openalex.org/W2460189675","https://openalex.org/W2370351381","https://openalex.org/W2433341169","https://openalex.org/W2041542789","https://openalex.org/W1600935440","https://openalex.org/W4231781208","https://openalex.org/W2046462443","https://openalex.org/W2156350934"],"abstract_inverted_index":{"Abstract":[0],"TGF-\u03b2":[1,15,36,46,68,112,139,151,182,308,340],"is":[2,29,41,47,113,136,309],"a":[3,72,114],"widely":[4],"expressed":[5,224,238,279],"pleiotropic":[6],"growth":[7,294],"factor":[8,22,346],"that":[9,58],"plays":[10],"complex":[11],"roles":[12],"in":[13,43,119,149,166,175,190,229,232,243,246,281,284,296,336,347],"tumorigenesis.":[14],"switches":[16],"from":[17,81,341],"tumor":[18,115,133,342],"suppressor":[19,134,343],"to":[20,30,49,62,128,270,303,344],"pro-oncogenic":[21,345],"during":[23],"breast":[24,76,87],"cancer":[25,77,348],"progression.":[26],"Our":[27],"goal":[28],"identify":[31],"molecular":[32],"determinants":[33],"of":[34,54,74,94,147,157,168,186,188,288,317,334,339,353],"the":[35,67,82,99,120,132,144,150,213,258,337,354],"switch.":[37,64],"Since":[38],"miRNA":[39,162,192],"expression":[40,51,155,193,204,253,287],"deregulated":[42],"cancer,":[44],"and":[45,52,106,138,173,177,180,210,262,276,313,361],"reported":[48],"regulate":[50,267],"biogenesis":[53],"miRNAs,":[55],"we":[56,70,153],"hypothesize":[57],"miRNAs":[59,148,158,202,222,236,251,266,290,304,335],"may":[60],"contribute":[61],"this":[63],"To":[65,142],"model":[66,92],"switch,":[69,152],"used":[71],"series":[73],"human":[75,86],"cell":[78,89,96,122,171,219,260],"lines":[79,172],"derived":[80],"spontaneously":[83],"immortalized":[84],"MCF10A":[85,100],"epithelial":[88],"line.":[90],"The":[91,315],"consists":[93],"4":[95],"lines.":[97,220],"In":[98,117],"(M-I;":[101],"normal),":[102],"MCF10AT":[103],"(M-II;":[104],"premalignant)":[105],"MCF10CA1hcl4":[107],"(M-IIIcl4;":[108],"low-grade":[109],"tumor)":[110],"lines,":[111,261],"suppressor.":[116],"contrast,":[118],"MCF10CA1a":[121],"line":[123],"(M-IV),":[124],"which":[125],"gives":[126],"rise":[127],"aggressive":[129],"metastatic":[130],"tumors,":[131],"activity":[135],"lost":[137],"promotes":[140],"metastasis.":[141],"test":[143],"possible":[145],"involvement":[146],"compared":[154],"profiles":[156],"by":[159,307],"Next":[160],"Gen":[161],"sequencing":[163],"1)":[164],"basally":[165,207],"cultures":[167],"all":[169],"four":[170],"2)":[174],"M-IIIcl4":[176,209,230,312],"M-IV":[178,244,282],"with":[179,194],"without":[181],"treatment.":[183],"A":[184,298],"variety":[185],"patterns":[187],"change":[189],"basal":[191],"malignant":[195],"progression":[196,349],"were":[197,223,237,278],"seen.":[198],"We":[199,248],"focused":[200],"on":[201,358],"whose":[203,252,305],"level":[205],"differs":[206],"between":[208,216,257,311],"M-IV,":[211,233],"since":[212],"switch":[214,338],"occurs":[215],"these":[217,265,289,318],"two":[218,259],"46":[221],">":[225,239],"1.5":[226,240],"fold":[227,241],"higher":[228,242,280],"than":[231,245,283],"whereas":[234],"29":[235],"M-IIIcl4.":[247,285,297],"selected":[249],"several":[250],"was":[254,301],"most":[255],"different":[256,310],"examined":[263],"whether":[264],"cellular":[268],"responses":[269],"TGF-\u03b2.":[271],"As":[272],"an":[273],"example,":[274],"let-7i":[275],"let-7g":[277],"Forced":[286],"partially":[291],"reversed":[292],"TGF-\u03b2-induced":[293],"inhibition":[295],"similar":[299],"strategy":[300],"applied":[302],"regulation":[306],"M-IV.":[314],"results":[316],"experiments":[319],"will":[320],"be":[321],"discussed.":[322],"Citation":[323],"Format:":[324],"Yoshiko":[325],"Nagano,":[326],"Maxwell":[327],"P.":[328],"Lee,":[329],"Lalage":[330],"M.":[331],"Wakefield.":[332],"Roles":[333],"[abstract].":[350],"In:":[351],"Proceedings":[352],"AACR":[355],"Special":[356],"Conference":[357],"Noncoding":[359],"RNAs":[360],"Cancer;":[362],"2012":[363],"Jan":[364],"8-11;":[365],"Miami":[366],"Beach,":[367],"FL.":[368],"Philadelphia":[369],"(PA):":[370],"AACR;":[371],"Cancer":[372],"Res":[373],"2012;72(2":[374],"Suppl):Abstract":[375],"nr":[376],"A7.":[377]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}