{"id":"https://openalex.org/W2002299218","doi":"https://doi.org/10.1093/nar/16.21.9979","title":"A new member of therasgene superfamily identified in a rat liver cell line","display_name":"A new member of therasgene superfamily identified in a rat liver cell line","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2002299218","doi":"https://doi.org/10.1093/nar/16.21.9979","mag":"2002299218","pmid":"https://pubmed.ncbi.nlm.nih.gov/3057452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/338831"},"language":"en","primary_location":{"id":"doi:10.1093/nar/16.21.9979","doi":"https://doi.org/10.1093/nar/16.21.9979","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/16.21.9979","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC338831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000258094","display_name":"Cecilia Bucci","orcid":"https://orcid.org/0000-0002-6232-6183","observed_orcids":["https://orcid.org/0000-0002-6232-6183","https://orcid.org/0009-0001-8719-0964"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Bucci","raw_affiliation_strings":["Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universit\u00e0 di Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universit\u00e0 di Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032429393","display_name":"Rodolfo Frunzio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodolfo Frunzio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089906264","display_name":"Lorenzo Chiariotti","orcid":"https://orcid.org/0000-0001-6097-4171","observed_orcids":["https://orcid.org/0000-0001-6097-4171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenzo Chiariotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101707169","display_name":"Alexandra L. Brown","orcid":"https://orcid.org/0000-0002-0372-4675","observed_orcids":["https://orcid.org/0000-0002-0372-4675"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra L. Brown","raw_affiliation_strings":["Molecular, Cellular and Nutritional Endocrinology Branch NIDDK, NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular and Nutritional Endocrinology Branch NIDDK, NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084959996","display_name":"Matthew M. Rechler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Rechler","raw_affiliation_strings":["Molecular, Cellular and Nutritional Endocrinology Branch NIDDK, NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular and Nutritional Endocrinology Branch NIDDK, NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111934091","display_name":"Carmelo Bruno Bruni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmelo B. Bruni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":2.3725,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.89650783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"21","first_page":"9979","last_page":"9993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7960000038146973},{"id":"https://openalex.org/keywords/gtp-binding-domain","display_name":"GTP-binding domain","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gtpase-activity","display_name":"GTPase activity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.4699999988079071},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.421999990940094},{"id":"https://openalex.org/keywords/rat-genome","display_name":"rat genome","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9410266876220703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7334773540496826},{"id":"https://openalex.org/C2781335528","wikidata":"https://www.wikidata.org/wiki/Q24781762","display_name":"Ras superfamily","level":4,"score":0.7049651145935059},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.6367279887199402},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6292300820350647},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.567297637462616},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.47486352920532227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3938714563846588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28743547201156616},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.236589252948761},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.142403244972229}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/16.21.9979","doi":"https://doi.org/10.1093/nar/16.21.9979","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/16.21.9979","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1459960","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC338831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:338831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/338831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:3057452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3057452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisalento.it:11587/101690","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11587/101690","pdf_url":null,"source":{"id":"https://openalex.org/S7407055257","display_name":"AIRUS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1459960","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC338831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W35071699","https://openalex.org/W49731348","https://openalex.org/W1007536749","https://openalex.org/W1008529600","https://openalex.org/W1492325161","https://openalex.org/W1511815713","https://openalex.org/W1519718418","https://openalex.org/W1545380907","https://openalex.org/W1666400257","https://openalex.org/W1819297632","https://openalex.org/W1858120728","https://openalex.org/W1872215511","https://openalex.org/W1906753041","https://openalex.org/W1988970153","https://openalex.org/W1996031776","https://openalex.org/W1996626295","https://openalex.org/W1999175930","https://openalex.org/W2004512194","https://openalex.org/W2011836510","https://openalex.org/W2014669590","https://openalex.org/W2018228515","https://openalex.org/W2018289835","https://openalex.org/W2020358132","https://openalex.org/W2025237524","https://openalex.org/W2026336642","https://openalex.org/W2028622989","https://openalex.org/W2029987769","https://openalex.org/W2034277598","https://openalex.org/W2035363409","https://openalex.org/W2046066271","https://openalex.org/W2050077441","https://openalex.org/W2056786827","https://openalex.org/W2057163724","https://openalex.org/W2057385958","https://openalex.org/W2058511768","https://openalex.org/W2058872832","https://openalex.org/W2060333964","https://openalex.org/W2061129160","https://openalex.org/W2063450941","https://openalex.org/W2078119356","https://openalex.org/W2078425071","https://openalex.org/W2078792023","https://openalex.org/W2080587793","https://openalex.org/W2080875376","https://openalex.org/W2084832908","https://openalex.org/W2087844645","https://openalex.org/W2088353293","https://openalex.org/W2100256775","https://openalex.org/W2100837269","https://openalex.org/W2138270253","https://openalex.org/W2152520101","https://openalex.org/W2161524167","https://openalex.org/W2308783294","https://openalex.org/W4232777855","https://openalex.org/W4234342751"],"related_works":["https://openalex.org/W2004512194","https://openalex.org/W35071699","https://openalex.org/W2064985672","https://openalex.org/W1994029240","https://openalex.org/W1960601813","https://openalex.org/W2082745575","https://openalex.org/W2128705781","https://openalex.org/W2070001832","https://openalex.org/W1989379237","https://openalex.org/W2060091607"],"abstract_inverted_index":{"A":[0,59],"new":[1],"member":[2],"of":[3,35,61],"the":[4,36,48,54,62,84],"ras":[5,37],"genes":[6],"superfamily":[7],"was":[8,67],"isolated":[9],"from":[10,15],"a":[11,16],"cDNA":[12],"library":[13],"derived":[14],"rat":[17,85],"liver":[18],"cell":[19,98],"line":[20],"(BRL-3A).":[21],"The":[22,75],"predicted":[23],"201":[24],"amino":[25],"acids":[26],"ras-like":[27],"protein":[28,60],"shows":[29],"30-35%":[30],"homology":[31],"with":[32],"other":[33],"members":[34],"and":[38,50,53,87,97],"ras-related":[39],"gene":[40,77],"products":[41],"so":[42],"far":[43],"described.":[44],"Conserved":[45],"features":[46],"include":[47],"GTP-binding":[49],"hydrolysis":[51],"domains":[52],"carboxyl":[55],"terminal":[56],"cysteine":[57],"residues.":[58],"expected":[63],"size":[64],"(Mr":[65],"23,000)":[66],"synthesized":[68],"in":[69,71,80,83,94],"an":[70],"vitro":[72],"transcription-translation":[73],"system.":[74],"BRL-ras":[76],"is":[78,88],"present":[79],"single":[81],"copy":[82],"genome":[86],"ubiquitously":[89],"expressed":[90],"at":[91],"high":[92],"levels":[93],"all":[95],"tissues":[96],"lines":[99],"examined.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}