{"id":"https://openalex.org/W2002279360","doi":"https://doi.org/10.1210/en.131.3.1063","title":"Follicle-stimulating hormone induces functional receptors for basic fibroblast growth factor in rat granulosa cells","display_name":"Follicle-stimulating hormone induces functional receptors for basic fibroblast growth factor in rat granulosa cells","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2002279360","doi":"https://doi.org/10.1210/en.131.3.1063","mag":"2002279360","pmid":"https://pubmed.ncbi.nlm.nih.gov/1324147"},"language":"en","primary_location":{"id":"doi:10.1210/en.131.3.1063","doi":"https://doi.org/10.1210/en.131.3.1063","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.131.3.1063","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013068699","display_name":"Toshihiko Shikone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Shikone","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wakayama Medical College, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wakayama Medical College, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054474479","display_name":"Mareo Yamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Yamoto","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wakayama Medical College, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wakayama Medical College, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004740539","display_name":"Ryuichi Nakano","orcid":"https://orcid.org/0000-0003-2086-2591","observed_orcids":["https://orcid.org/0000-0003-2086-2591"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Nakano","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wakayama Medical College, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wakayama Medical College, Japan","institution_ids":["https://openalex.org/I190805021"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I190805021"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.5645,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.82910446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"131","issue":"3","first_page":"1063","last_page":"1068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.11760000139474869,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9390000104904175},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bfgf-receptor","display_name":"bFGF receptor","score":0.7559999823570251},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/receptor-induction","display_name":"receptor induction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.75},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9800000190734863},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.7250000238418579},{"id":"https://openalex.org/keywords/fsh-priming","display_name":"FSH priming","score":0.6129999756813049},{"id":"https://openalex.org/keywords/oocyte-differentiation","display_name":"oocyte differentiation","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.8578420877456665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7983782291412354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.771928608417511},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.6681629419326782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6182124614715576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5471977591514587},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5356724858283997},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4392624497413635},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.41399717330932617},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.40565407276153564},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3799859881401062},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.291609525680542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09798577427864075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.131.3.1063","doi":"https://doi.org/10.1210/en.131.3.1063","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.131.3.1063","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.131.3.1324147","doi":"https://doi.org/10.1210/endo.131.3.1324147","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.131.3.1324147","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:1324147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1324147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"mag:2267930860","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000101399?l=ja","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1591495971","https://openalex.org/W1970516412","https://openalex.org/W1973983380","https://openalex.org/W1984648137","https://openalex.org/W1992327323","https://openalex.org/W2009509886","https://openalex.org/W2010833294","https://openalex.org/W2024787221","https://openalex.org/W2026853181","https://openalex.org/W2035172569","https://openalex.org/W2039213845","https://openalex.org/W2044568122","https://openalex.org/W2060572191","https://openalex.org/W2082267164","https://openalex.org/W2094206083","https://openalex.org/W2105354674","https://openalex.org/W2111544730","https://openalex.org/W2128749862","https://openalex.org/W2131391777","https://openalex.org/W2133685524","https://openalex.org/W2144957328","https://openalex.org/W2151607232","https://openalex.org/W2188638493"],"related_works":["https://openalex.org/W2042861570","https://openalex.org/W2089483086","https://openalex.org/W2151607232","https://openalex.org/W2021283573","https://openalex.org/W2060572191","https://openalex.org/W2036483376","https://openalex.org/W2067967344","https://openalex.org/W1007771602","https://openalex.org/W2083158575","https://openalex.org/W2161276384"],"abstract_inverted_index":{"In":[0],"the":[1,6,63,72,77,93,105,123,155,168,200,205],"present":[2,179],"study":[3,180],"we":[4],"examined":[5],"existence":[7],"of":[8,25,71,80,96,126,171,202,207],"receptors":[9,186],"for":[10,51,187],"basic":[11],"fibroblast":[12],"growth":[13,41],"factor":[14],"(bFGF)":[15],"and":[16,141,192],"its":[17],"regulation":[18],"in":[19,48,107,122,137,154,189,199],"rat":[20,29,55],"granulosa":[21,30,56,143,190],"cells.":[22,57],"The":[23,162,178],"binding":[24,50,64,95,109],"labeled":[26],"bFGF":[27,52,73,108,127,131,149,166,172,188,194],"to":[28,53,148,159],"cells":[31,144,191],"was":[32],"dose-dependently":[33],"displaced":[34],"by":[35,111],"unlabeled":[36],"bFGF,":[37],"but":[38,75],"not":[39,61],"other":[40],"factors.":[42],"FSH":[43,58,124,183],"induced":[44,110],"a":[45,100,138,152,197],"dose-dependent":[46,139],"increase":[47,106],"specific":[49,94],"cultured":[54],"treatment":[59,84],"did":[60],"change":[62],"affinity":[65],"(Kd,":[66],"2.8-3.0":[67],"x":[68],"10(-10)":[69],"M)":[70],"receptor,":[74],"increased":[76],"total":[78],"number":[79],"bFGF-binding":[81],"sites,":[82],"whereas":[83],"with":[85,151],"several":[86],"steroid":[87],"hormones":[88],"had":[89],"no":[90],"effect":[91,170],"on":[92,173],"bFGF.":[97],"Since":[98],"cycloheximide,":[99],"protein":[101,117],"synthesis":[102,118],"inhibitor,":[103],"inhibited":[104],"FSH,":[112],"it":[113],"is":[114],"suggested":[115],"that":[116,182,193],"might":[119],"be":[120],"involved":[121],"stimulation":[125],"receptor":[128],"induction.":[129],"Furthermore,":[130],"stimulated":[132],"tissue":[133,174],"plasminogen":[134,175],"activator":[135,176],"activity":[136],"manner,":[140],"FSH-primed":[142],"were":[145],"more":[146],"responsive":[147],"action,":[150],"decrease":[153],"ED50":[156],"from":[157],"5.0":[158],"1.5":[160],"ng/ml.":[161],"antibody":[163],"against":[164],"human":[165],"neutralized":[167],"stimulatory":[169],"secretion.":[177],"suggests":[181],"induces":[184],"functional":[185],"may":[195],"play":[196],"role":[198],"process":[201],"differentiation":[203],"under":[204],"influence":[206],"FSH.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}