{"id":"https://openalex.org/W2002259954","doi":"https://doi.org/10.4103/2231-4040.111525","title":"Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats","display_name":"Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2002259954","doi":"https://doi.org/10.4103/2231-4040.111525","mag":"2002259954","pmid":"https://pubmed.ncbi.nlm.nih.gov/23833749","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696228"},"language":"en","primary_location":{"id":"doi:10.4103/2231-4040.111525","doi":"https://doi.org/10.4103/2231-4040.111525","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2231-4040.111525","pdf_url":null,"source":{"id":"https://openalex.org/S2764715273","display_name":"Journal of Advanced Pharmaceutical Technology amp Research","issn_l":"0976-2094","issn":["0976-2094","2231-4040"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Pharmaceutical Technology &amp; Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/2231-4040.111525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102950108","display_name":"T.S. Mohamed Saleem","orcid":"https://orcid.org/0000-0003-4890-8651","observed_orcids":["https://orcid.org/0000-0003-4890-8651"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"TS Mohamed Saleem","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081390450","display_name":"Neratur Krishnappagowda Lokanath","orcid":"https://orcid.org/0000-0003-2773-2247","observed_orcids":["https://orcid.org/0000-0003-2773-2247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Lokanath","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012364749","display_name":"A.G. Prasanthi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Prasanthi","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Madhavi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Madhavi","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093651283","display_name":"G. Mallika","orcid":"https://orcid.org/0009-0002-2986-7030","observed_orcids":["https://orcid.org/0009-0002-2986-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Mallika","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057017743","display_name":"M. Suryawanshi Vishnu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MN Vishnu","raw_affiliation_strings":["Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102950108"],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":2.3111,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.88865859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"94","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saussurea-lappa","display_name":"Saussurea lappa","score":1.0},{"id":"https://openalex.org/keywords/aqueous-root-extract","display_name":"aqueous root extract","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9490000009536743},{"id":"https://openalex.org/keywords/isoproterenol-induced-myocardial-injury","display_name":"isoproterenol-induced myocardial injury","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8289999961853027},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.8029999732971191},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ayurveda","display_name":"Ayurveda","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.9050686359405518},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.7229915857315063},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.6672448515892029},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5342710614204407},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.5327223539352417},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4817659854888916},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.46126610040664673},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.45973196625709534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.450927197933197},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.44034281373023987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43850621581077576},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.4129668176174164},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.38804900646209717},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3370385766029358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28132331371307373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19502830505371094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15553298592567444},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.0824093222618103},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4103/2231-4040.111525","doi":"https://doi.org/10.4103/2231-4040.111525","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2231-4040.111525","pdf_url":null,"source":{"id":"https://openalex.org/S2764715273","display_name":"Journal of Advanced Pharmaceutical Technology amp Research","issn_l":"0976-2094","issn":["0976-2094","2231-4040"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Pharmaceutical Technology &amp; Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3696228","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3696228/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3696228/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Adv Pharm Technol Res","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2697711","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3696228","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23833749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23833749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of advanced pharmaceutical technology & research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7f562aa1a9d140c6bb70012435aead49","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f562aa1a9d140c6bb70012435aead49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Advanced Pharmaceutical Technology & Research, Vol 4, Iss 2, Pp 94-100 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/2231-4040.111525","doi":"https://doi.org/10.4103/2231-4040.111525","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2231-4040.111525","pdf_url":null,"source":{"id":"https://openalex.org/S2764715273","display_name":"Journal of Advanced Pharmaceutical Technology amp Research","issn_l":"0976-2094","issn":["0976-2094","2231-4040"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Pharmaceutical Technology &amp; Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002259954.pdf","grobid_xml":"https://content.openalex.org/works/W2002259954.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1525340835","https://openalex.org/W1839803445","https://openalex.org/W1969276344","https://openalex.org/W1973893677","https://openalex.org/W1980823360","https://openalex.org/W1983310681","https://openalex.org/W2006370393","https://openalex.org/W2022791060","https://openalex.org/W2025388470","https://openalex.org/W2028059098","https://openalex.org/W2053649825","https://openalex.org/W2057603320","https://openalex.org/W2075664500","https://openalex.org/W2114726424","https://openalex.org/W2204912245","https://openalex.org/W2405118366"],"related_works":["https://openalex.org/W4223932293","https://openalex.org/W7172308634","https://openalex.org/W2325849685","https://openalex.org/W2093216124","https://openalex.org/W2157456029","https://openalex.org/W7100681039","https://openalex.org/W4396621939","https://openalex.org/W2763651397","https://openalex.org/W1997339907","https://openalex.org/W2036720295"],"abstract_inverted_index":{"Saussurea":[0],"lappa":[1,22,47,81],"Clarke":[2],"(Compositae),":[3],"is":[4,12,137],"commonly":[5],"known":[6],"as":[7],"Kushta.":[8],"In":[9],"Ayurvedha,":[10],"it":[11],"mentioned":[13],"that":[14,198],"the":[15,19,37,60,76,94,154,170,192],"aqueous":[16,41,77],"extract":[17,42,78,165],"of":[18,27,40,43,45,62,67,79,104,146,156,194],"root":[20,44],"S.":[21,46,80],"was":[23,33,57,167,189],"used":[24],"for":[25],"treatment":[26],"angina":[28],"pectoris.":[29],"The":[30,71,164,184],"present":[31],"study":[32],"designed":[34],"to":[35,130],"investigate":[36],"cardioprotective":[38],"effect":[39,166,187],"against":[48,204],"isoproterenol":[49,63,205],"induced":[50,58,206],"myocardial":[51,116,125,131,157,207],"injury.":[52,208],"Myocardial":[53],"injury":[54],"in":[55,83,148,179],"rat":[56],"by":[59,134,140],"administration":[61,145],"at":[64],"a":[65],"dose":[66,193],"85":[68],"mg/kg,":[69,91],"i.p.,":[70],"rats":[72,99],"were":[73],"pretreated":[74],"with":[75,169,191],"(AESL)":[82],"three":[84,149],"different":[85,150],"doses":[86,151],"(100,":[87],"200":[88,195],"and":[89,111,123,162,181],"300":[90],"p.o.)":[92],"through":[93],"oral":[95,144],"route.":[96],"Isoproterenol":[97],"alone-treated":[98],"showed":[100],"increased":[101,115],"serum":[102],"concentration":[103],"lactate":[105],"dehydrogenase":[106],"(LDH),":[107],"creatinine":[108],"kinase":[109],"(CK),":[110],"aspartate":[112],"transaminase":[113],"(AST),":[114],"thiobarbituric":[117],"acid":[118],"reactive":[119],"substances":[120],"(TBARS)":[121],"level,":[122],"decreased":[124],"glutathione":[126],"(GSH)":[127],"level":[128,155],"due":[129],"damage":[132],"produced":[133,200],"isoproterenol.":[135],"This":[136],"further":[138],"conformed":[139],"histopathological":[141,182],"changes.":[142,183],"Chronic":[143],"AESL":[147,199],"significantly":[152],"restored":[153],"LDH,":[158],"CK,":[159],"AST,":[160],"TBARS,":[161],"GSH.":[163],"compared":[168],"reference":[171],"standard":[172],"\u03b1-tocopherol":[173],"which":[174,188],"also":[175],"offered":[176],"similar":[177],"protection":[178],"biochemical":[180],"overall":[185],"beneficial":[186],"observed":[190],"mg/kg":[196],"indicated":[197],"significant":[201],"dose-dependent":[202],"activity":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
