{"id":"https://openalex.org/W2002259190","doi":"https://doi.org/10.1016/j.molcel.2006.01.028","title":"A Transient Heterochromatic State in Xist Preempts X Inactivation Choice without RNA Stabilization","display_name":"A Transient Heterochromatic State in Xist Preempts X Inactivation Choice without RNA Stabilization","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2002259190","doi":"https://doi.org/10.1016/j.molcel.2006.01.028","mag":"2002259190","pmid":"https://pubmed.ncbi.nlm.nih.gov/16507360"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2006.01.028","doi":"https://doi.org/10.1016/j.molcel.2006.01.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2006.01.028","pdf_url":"http://www.cell.com/article/S1097276506000505/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2002259190"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1097276506000505/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013016915","display_name":"Bryan K. Sun","orcid":"https://orcid.org/0000-0002-0740-0125","observed_orcids":["https://orcid.org/0000-0002-0740-0125"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan K. Sun","raw_affiliation_strings":["Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, 02114, USA","Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, 02114, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043252915","display_name":"Aim\u00e9e M. Deaton","orcid":"https://orcid.org/0000-0003-0365-3077","observed_orcids":["https://orcid.org/0000-0003-0365-3077"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aim\u00e9e M. Deaton","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007941136","display_name":"Jeannie T. Lee","orcid":"https://orcid.org/0000-0001-7786-8850","observed_orcids":["https://orcid.org/0000-0001-7786-8850"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeannie T. Lee","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007941136"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":10.7716,"has_fulltext":false,"cited_by_count":298,"citation_normalized_percentile":{"value":0.99029502,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"21","issue":"5","first_page":"617","last_page":"628"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/xist","display_name":"XIST","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tsix","display_name":"Tsix","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/rna-stability","display_name":"RNA stability","score":0.4519999921321869},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cis-regulation","display_name":"cis-regulation","score":0.47699999809265137},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.4699999988079071},{"id":"https://openalex.org/keywords/chromatin-marks","display_name":"chromatin marks","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C110411900","wikidata":"https://www.wikidata.org/wiki/Q18032385","display_name":"XIST","level":5,"score":0.9346532821655273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9214770793914795},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5860146284103394},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.5358264446258545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42729076743125916},{"id":"https://openalex.org/C4323932","wikidata":"https://www.wikidata.org/wiki/Q898914","display_name":"X-inactivation","level":4,"score":0.4211009740829468},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3695623576641083},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.18673551082611084},{"id":"https://openalex.org/C35158069","wikidata":"https://www.wikidata.org/wiki/Q61333","display_name":"X chromosome","level":3,"score":0.12502986192703247},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12233737111091614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11825355887413025}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049951","descriptor_name":"X Chromosome Inactivation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.molcel.2006.01.028","doi":"https://doi.org/10.1016/j.molcel.2006.01.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2006.01.028","pdf_url":"http://www.cell.com/article/S1097276506000505/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:16507360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16507360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2006.01.028","doi":"https://doi.org/10.1016/j.molcel.2006.01.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2006.01.028","pdf_url":"http://www.cell.com/article/S1097276506000505/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2002259190.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1508367671","https://openalex.org/W1535914077","https://openalex.org/W1939654294","https://openalex.org/W1968508123","https://openalex.org/W1978324852","https://openalex.org/W1986277038","https://openalex.org/W1989287162","https://openalex.org/W2008620032","https://openalex.org/W2015132841","https://openalex.org/W2025998749","https://openalex.org/W2028907427","https://openalex.org/W2029146706","https://openalex.org/W2033384260","https://openalex.org/W2036111380","https://openalex.org/W2036322758","https://openalex.org/W2047333953","https://openalex.org/W2048791985","https://openalex.org/W2052074936","https://openalex.org/W2056385746","https://openalex.org/W2060446375","https://openalex.org/W2062313490","https://openalex.org/W2063622359","https://openalex.org/W2068225054","https://openalex.org/W2078174011","https://openalex.org/W2097295510","https://openalex.org/W2101943126","https://openalex.org/W2104882487","https://openalex.org/W2105702946","https://openalex.org/W2107011634","https://openalex.org/W2108741433","https://openalex.org/W2110576356","https://openalex.org/W2115447301","https://openalex.org/W2118442396","https://openalex.org/W2129578444","https://openalex.org/W2132291190","https://openalex.org/W2137808356","https://openalex.org/W2142445831","https://openalex.org/W2142928043","https://openalex.org/W2149790281","https://openalex.org/W2151505389","https://openalex.org/W2158156090","https://openalex.org/W2168763523","https://openalex.org/W2169765259","https://openalex.org/W4238656497","https://openalex.org/W7001298847"],"related_works":["https://openalex.org/W2517526273","https://openalex.org/W2110576356","https://openalex.org/W2129578444","https://openalex.org/W3205747490","https://openalex.org/W2078174011","https://openalex.org/W4289262352","https://openalex.org/W3169771247","https://openalex.org/W3035356371","https://openalex.org/W1630833910","https://openalex.org/W1583136479"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
