{"id":"https://openalex.org/W2002249283","doi":"https://doi.org/10.1056/nejmoa053783","title":"Daptomycin versus Standard Therapy for Bacteremia and Endocarditis Caused by Staphylococcus aureus","display_name":"Daptomycin versus Standard Therapy for Bacteremia and Endocarditis Caused by Staphylococcus aureus","publication_year":2006,"publication_date":"2006-08-16","ids":{"openalex":"https://openalex.org/W2002249283","doi":"https://doi.org/10.1056/nejmoa053783","mag":"2002249283","pmid":"https://pubmed.ncbi.nlm.nih.gov/16914701"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa053783","doi":"https://doi.org/10.1056/nejmoa053783","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa053783","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa053783?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa053783?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045500368","display_name":"Vance G. Fowler","orcid":"https://orcid.org/0000-0002-8048-0897","observed_orcids":["https://orcid.org/0000-0002-8048-0897"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vance G. Fowler","raw_affiliation_strings":["Duke University Medical Center, Durham, NC 27710, USA. vance.fowler@duke.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC 27710, USA. vance.fowler@duke.edu","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109277948","display_name":"Helen W. Boucher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen W. Boucher","raw_affiliation_strings":["Tufts New England Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts New England Medical Center","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059959498","display_name":"G. Ralph Corey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Ralph Corey","raw_affiliation_strings":["Duke University Medical Center, Durham, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, N.C","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044917251","display_name":"El\u00edas Abrutyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Abrutyn","raw_affiliation_strings":["Drexel University College of Medicine, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drexel University College of Medicine, Philadelphia","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030548278","display_name":"Adolf W. Karchmer","orcid":"https://orcid.org/0000-0001-5113-6395","observed_orcids":["https://orcid.org/0000-0001-5113-6395"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adolf W. Karchmer","raw_affiliation_strings":["Beth Israel Deaconess Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009557285","display_name":"Mark E. Rupp","orcid":"https://orcid.org/0000-0001-8946-8272","observed_orcids":["https://orcid.org/0000-0001-8946-8272"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Rupp","raw_affiliation_strings":["University of Nebraska Medical Center, Omaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Omaha","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004573937","display_name":"Donald P. Levine","orcid":"https://orcid.org/0000-0003-2252-5820","observed_orcids":["https://orcid.org/0000-0003-2252-5820"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald P. Levine","raw_affiliation_strings":["Wayne State University School of Medicine, Detroit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University School of Medicine, Detroit","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032051822","display_name":"Henry F. \u201cChip\u201d Chambers","orcid":"https://orcid.org/0000-0001-5317-4491","observed_orcids":["https://orcid.org/0000-0001-5317-4491"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry F. Chambers","raw_affiliation_strings":["San Francisco General Hospital, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Francisco General Hospital, San Francisco","institution_ids":["https://openalex.org/I1295908608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642979","display_name":"Francis P. Tally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97187500","display_name":"Cubist Pharmaceuticals (United States)","ror":"https://ror.org/02xwa6p02","country_code":"US","type":"company","lineage":["https://openalex.org/I97187500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis P. Tally","raw_affiliation_strings":["Cubist Pharmaceuticals, Lexington, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cubist Pharmaceuticals, Lexington, Mass","institution_ids":["https://openalex.org/I97187500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078165099","display_name":"Gloria A. Vigliani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97187500","display_name":"Cubist Pharmaceuticals (United States)","ror":"https://ror.org/02xwa6p02","country_code":"US","type":"company","lineage":["https://openalex.org/I97187500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria A. Vigliani","raw_affiliation_strings":["Cubist Pharmaceuticals, Lexington, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cubist Pharmaceuticals, Lexington, Mass","institution_ids":["https://openalex.org/I97187500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062709502","display_name":"Christopher H. Cabell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher H. Cabell","raw_affiliation_strings":["Duke University Medical Center, Durham, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, N.C","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009818555","display_name":"Arthur S. Link","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158401","display_name":"Novant Health Forsyth Medical Center","ror":"https://ror.org/04mm17p39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802152183","https://openalex.org/I4210158401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Stanley Link","raw_affiliation_strings":["Forsyth Medical Center, Winston-Salem, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forsyth Medical Center, Winston-Salem, N.C","institution_ids":["https://openalex.org/I4210158401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063257464","display_name":"Ignace Demeyer","orcid":"https://orcid.org/0009-0008-0294-2460","observed_orcids":["https://orcid.org/0009-0008-0294-2460","https://orcid.org/0000-0003-3645-6299"]},"institutions":[{"id":"https://openalex.org/I4210101486","display_name":"Onze Lieve Vrouwziekenhuis Hospital","ror":"https://ror.org/00zrfhe30","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210101486"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ignace DeMeyer","raw_affiliation_strings":["Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium","institution_ids":["https://openalex.org/I4210101486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804086","display_name":"Scott G. Filler","orcid":"https://orcid.org/0000-0001-7278-3700","observed_orcids":["https://orcid.org/0000-0001-7278-3700"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott G. Filler","raw_affiliation_strings":["Harbor\u2013UCLA Medical Center, Torrance, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbor\u2013UCLA Medical Center, Torrance, Calif","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045626390","display_name":"Marcus Zervos","orcid":"https://orcid.org/0000-0002-7328-4898","observed_orcids":["https://orcid.org/0000-0002-7328-4898"]},"institutions":[{"id":"https://openalex.org/I4210128757","display_name":"Beaumont Hospital, Royal Oak","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Zervos","raw_affiliation_strings":["William Beaumont Hospital, Royal Oak, Mich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Beaumont Hospital, Royal Oak, Mich","institution_ids":["https://openalex.org/I4210128757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109769727","display_name":"Paul Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Cook","raw_affiliation_strings":["East Carolina University, Greenville, N.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Carolina University, Greenville, N.C","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeffrey Parsonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Parsonnet","raw_affiliation_strings":["Dartmouth\u2013Hitchcock Medical Center, Lebanon, N.H"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth\u2013Hitchcock Medical Center, Lebanon, N.H","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077621600","display_name":"Jack M. Bernstein","orcid":"https://orcid.org/0009-0004-9793-2214","observed_orcids":["https://orcid.org/0009-0004-9793-2214"]},"institutions":[{"id":"https://openalex.org/I4210131414","display_name":"Dayton VA Medical Center","ror":"https://ror.org/03qjk6p58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210127612","https://openalex.org/I4210131414"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack M. Bernstein","raw_affiliation_strings":["Veterans Affairs Medical Center, Dayton, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center, Dayton, Ohio","institution_ids":["https://openalex.org/I4210131414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077588689","display_name":"Connie Savor Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie Savor Price","raw_affiliation_strings":["Denver Health Medical, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver Health Medical, Denver","institution_ids":["https://openalex.org/I2801983979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035007857","display_name":"Graeme N. Forrest","orcid":"https://orcid.org/0000-0002-6235-8978","observed_orcids":["https://orcid.org/0000-0002-6235-8978"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4405257352","display_name":"University of Maryland School of Medicine","ror":"https://ror.org/055yg0521","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593","https://openalex.org/I4405257352"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graeme N. Forrest","raw_affiliation_strings":["University of Maryland School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland School of Medicine","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4405257352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062744631","display_name":"Gerd F\u00e4tkenheuer","orcid":"https://orcid.org/0000-0002-5054-1871","observed_orcids":["https://orcid.org/0000-0002-5054-1871"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd F\u00e4tkenheuer","raw_affiliation_strings":["Klinikum, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042601195","display_name":"Marcelo Gareca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133885","display_name":"Lehigh Valley Hospital","ror":"https://ror.org/03h4fx826","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094360","https://openalex.org/I4210133885"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelo Gareca","raw_affiliation_strings":["Lehigh Valley Hospital Trauma and Critical Care Research, Allentown, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lehigh Valley Hospital Trauma and Critical Care Research, Allentown, Pa","institution_ids":["https://openalex.org/I4210133885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087329899","display_name":"Susan J. Rehm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan J. Rehm","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816812","display_name":"H.-R. Brodt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Reinhardt Brodt","raw_affiliation_strings":["Johann Wolfgang Goethe Universit\u00e4t, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johann Wolfgang Goethe Universit\u00e4t, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109937408","display_name":"Alan Douglas Tice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Tice","raw_affiliation_strings":["University of Hawaii, and Queens Medical Center \u2014 both in Honolulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawaii, and Queens Medical Center \u2014 both in Honolulu","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210104115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018437292","display_name":"Sara E. Cosgrove","orcid":"https://orcid.org/0000-0001-9458-4331","observed_orcids":["https://orcid.org/0000-0001-9458-4331"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara E. Cosgrove","raw_affiliation_strings":["Johns Hopkins University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":27,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":78.1361,"has_fulltext":true,"cited_by_count":1466,"citation_normalized_percentile":{"value":0.99971788,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"355","issue":"7","first_page":"653","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.18209999799728394,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daptomycin","display_name":"daptomycin","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-aureus-bacteremia","display_name":"Staphylococcus aureus bacteremia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/right-sided-infective-endocarditis","display_name":"right-sided endocarditis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7699999809265137},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.9673188924789429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9505288600921631},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.7989875078201294},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7444629669189453},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.733063280582428},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5864259004592896},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.569497287273407},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5285478830337524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5006999969482422},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.47752630710601807},{"id":"https://openalex.org/C2780176578","wikidata":"https://www.wikidata.org/wiki/Q2450598","display_name":"Infective endocarditis","level":2,"score":0.46500644087791443},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4408803880214691},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4112875163555145},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.05232933163642883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa053783","doi":"https://doi.org/10.1056/nejmoa053783","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa053783","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa053783?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:16914701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16914701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1056/nejmoa053783","doi":"https://doi.org/10.1056/nejmoa053783","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa053783","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa053783?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002249283.pdf","grobid_xml":"https://content.openalex.org/works/W2002249283.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1550111394","https://openalex.org/W1975150477","https://openalex.org/W1978679680","https://openalex.org/W2013423572","https://openalex.org/W2023046401","https://openalex.org/W2044087791","https://openalex.org/W2053889635","https://openalex.org/W2074827635","https://openalex.org/W2082441919","https://openalex.org/W2098407100","https://openalex.org/W2099481682","https://openalex.org/W2107372728","https://openalex.org/W2118546214","https://openalex.org/W2126874955","https://openalex.org/W2129543141","https://openalex.org/W2143084812","https://openalex.org/W2156451821","https://openalex.org/W2157572113","https://openalex.org/W2160244430","https://openalex.org/W2167973138","https://openalex.org/W2171155970","https://openalex.org/W2171436655","https://openalex.org/W2172100866","https://openalex.org/W2329427515","https://openalex.org/W2340388705","https://openalex.org/W4236600412"],"related_works":["https://openalex.org/W2307737358","https://openalex.org/W3091755651","https://openalex.org/W2407966126","https://openalex.org/W2144963218","https://openalex.org/W2078444411","https://openalex.org/W2807625228","https://openalex.org/W2157018267","https://openalex.org/W2921148263","https://openalex.org/W2573615115","https://openalex.org/W2332069639"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alternative":[1],"therapies":[2],"for":[3,85,126,273],"Staphylococcus":[4],"aureus":[5,19,275],"bacteremia":[6,20,276],"and":[7,38,145,249,277],"endocarditis":[8,24],"are":[9],"needed.":[10],"METHODS:":[11],"We":[12],"randomly":[13],"assigned":[14],"124":[15],"patients":[16,89,99,139,174,200,245,254],"with":[17,21,95,140,153,175,183,202,206,213],"S.":[18,147,274],"or":[22,50],"without":[23],"to":[25,40,118,186,193,223,227,270],"receive":[26,41],"6":[27,170],"mg":[28,263],"of":[29,34,65,73,87,97,129,138,157,171,218,230,244,253],"daptomycin":[30,92,180,187,207,248],"intravenously":[31],"per":[32,264],"kilogram":[33,265],"body":[35],"weight":[36],"daily":[37],"122":[39],"initial":[42],"low-dose":[43],"gentamicin":[44],"plus":[45],"either":[46],"an":[47],"antistaphylococcal":[48],"penicillin":[49],"vancomycin.":[51,203],"The":[52,131],"primary":[53],"efficacy":[54],"end":[55,64,72],"point":[56],"was":[57,83,151,161,195,211],"treatment":[58,224],"success":[59,132],"42":[60],"days":[61,69],"after":[62,70],"the":[63,71,76,127,172,179,228],"therapy.":[66],"RESULTS:":[67],"Forty-two":[68],"therapy":[74,103,150,163,210,231,258,272],"in":[75,136,178,197,241,250],"modified":[77],"intention-to-treat":[78],"analysis,":[79],"a":[80,154,190,214],"successful":[81],"outcome":[82],"documented":[84],"53":[86],"120":[88],"who":[90,100,246,255],"received":[91,101,247,256],"as":[93],"compared":[94,205],"48":[96],"115":[98],"standard":[102,162,209,257,271],"(44.2":[104],"percent":[105,114,243,252],"vs.":[106,165,233],"41.7":[107],"percent;":[108,112],"absolute":[109],"difference,":[110],"2.4":[111],"95":[113],"confidence":[115],"interval,":[116],"-10.2":[117],"15.1":[119],"percent).":[120],"Our":[121],"results":[122],"met":[123],"prespecified":[124],"criteria":[125],"noninferiority":[128],"daptomycin.":[130],"rates":[133],"were":[134],"similar":[135],"subgroups":[137],"complicated":[141],"bacteremia,":[142],"right-sided":[143,278],"endocarditis,":[144],"methicillin-resistant":[146],"aureus.":[148],"Daptomycin":[149,261],"associated":[152,212],"higher":[155,216],"rate":[156,217],"microbiologic":[158,176],"failure":[159,177,225],"than":[160],"(19":[164],"11":[166],"patients,":[167],"P=0.17).":[168],"In":[169],"19":[173],"group,":[181],"isolates":[182,198],"reduced":[184,191],"susceptibility":[185,192],"emerged;":[188],"similarly,":[189],"vancomycin":[194],"noted":[196],"from":[199],"treated":[201],"As":[204],"therapy,":[208],"nonsignificantly":[215],"adverse":[219],"events":[220],"that":[221],"led":[222],"due":[226],"discontinuation":[229],"(17":[232],"8,":[234],"P=0.06).":[235],"Clinically":[236],"significant":[237],"renal":[238],"dysfunction":[239],"occurred":[240],"11.0":[242],"26.3":[251],"(P=0.004).":[259],"CONCLUSIONS:":[260],"(6":[262],"daily)":[266],"is":[267],"not":[268],"inferior":[269],"endocarditis.":[279],"(ClinicalTrials.gov":[280],"number,":[281],"NCT00093067":[282],"[ClinicalTrials.gov].).":[283]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":40},{"year":2023,"cited_by_count":56},{"year":2022,"cited_by_count":49},{"year":2021,"cited_by_count":48},{"year":2020,"cited_by_count":55},{"year":2019,"cited_by_count":61},{"year":2018,"cited_by_count":53},{"year":2017,"cited_by_count":50},{"year":2016,"cited_by_count":65},{"year":2015,"cited_by_count":88},{"year":2014,"cited_by_count":77},{"year":2013,"cited_by_count":103},{"year":2012,"cited_by_count":95}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}