{"id":"https://openalex.org/W2002246721","doi":"https://doi.org/10.1159/000340048","title":"An Acquired Defect Associated with Abnormal Signaling of the Platelet Collagen Receptor Glycoprotein VI","display_name":"An Acquired Defect Associated with Abnormal Signaling of the Platelet Collagen Receptor Glycoprotein VI","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2002246721","doi":"https://doi.org/10.1159/000340048","mag":"2002246721","pmid":"https://pubmed.ncbi.nlm.nih.gov/22922528"},"language":"en","primary_location":{"id":"doi:10.1159/000340048","doi":"https://doi.org/10.1159/000340048","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000340048","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112042086","display_name":"Jianlin Qiao","orcid":"https://orcid.org/0000-0002-0456-0940","observed_orcids":["https://orcid.org/0000-0002-0456-0940"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jianlin Qiao","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, Melbourne, Vic., Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, Melbourne, Vic., Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108087947","display_name":"Jane Frances Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jane F. Arthur","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, and","Australian Centre for Blood Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, and","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Centre for Blood Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017020393","display_name":"Margaret F. Collecutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Margaret Collecutt","raw_affiliation_strings":["Department of Clinical Haematology, The Alfred, Melbourne, Vic., Australia;","Alfred Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Haematology, The Alfred, Melbourne, Vic., Australia;","institution_ids":["https://openalex.org/I2801993434"]},{"raw_affiliation_string":"Alfred Health","institution_ids":["https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101854857","display_name":"Yang Shen","orcid":"https://orcid.org/0009-0009-3181-2574","observed_orcids":["https://orcid.org/0009-0009-3181-2574"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yang Shen","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, and","Australian Centre for Blood Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, and","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Centre for Blood Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111826335","display_name":"Fi\u2010Tjen Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fi-Tjen Mu","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, and","Australian Centre for Blood Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, and","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Centre for Blood Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107835527","display_name":"Michael C. Berndt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael C. Berndt","raw_affiliation_strings":["Biomedical Diagnostics Institute, Dublin City University, and Royal College of Surgeons in Ireland, Dublin, Ireland","Dublin City University#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Diagnostics Institute, Dublin City University, and Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I42934936"]},{"raw_affiliation_string":"Dublin City University#TAB#","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006336589","display_name":"Amanda Katherine Davis","orcid":"https://orcid.org/0000-0002-2752-1522","observed_orcids":["https://orcid.org/0000-0002-2752-1522"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amanda K. Davis","raw_affiliation_strings":["Department of Clinical Haematology, The Alfred, Melbourne, Vic., Australia;","Alfred Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Haematology, The Alfred, Melbourne, Vic., Australia;","institution_ids":["https://openalex.org/I2801993434"]},{"raw_affiliation_string":"Alfred Health","institution_ids":["https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105934314","display_name":"Robert K. Andrews","orcid":"https://orcid.org/0000-0001-9577-8082","observed_orcids":["https://orcid.org/0000-0001-9577-8082"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert K. Andrews","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, and","Australian Centre for Blood Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, and","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Centre for Blood Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072400072","display_name":"Elizabeth E. Gardiner","orcid":"https://orcid.org/0000-0001-9453-9688","observed_orcids":["https://orcid.org/0000-0001-9453-9688"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elizabeth E. Gardiner","raw_affiliation_strings":["Australian Centre for Blood Diseases, Monash University, and","Australian Centre for Blood Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Centre for Blood Diseases, Monash University, and","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Centre for Blood Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.409,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64670719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"128","issue":"4","first_page":"233","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein-vi","display_name":"glycoprotein VI","score":0.9760000109672546},{"id":"https://openalex.org/keywords/platelet-collagen-receptor","display_name":"platelet collagen receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8759999871253967},{"id":"https://openalex.org/keywords/syk-phosphorylation","display_name":"Syk phosphorylation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/collagen-related-peptide","display_name":"collagen-related peptide","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9509999752044678},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2780573682","wikidata":"https://www.wikidata.org/wiki/Q14905651","display_name":"GPVI","level":4,"score":0.9952614903450012},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.9802817106246948},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6587961912155151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6429808139801025},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6113153696060181},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5794445872306824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5319861173629761},{"id":"https://openalex.org/C26828662","wikidata":"https://www.wikidata.org/wiki/Q7202248","display_name":"Platelet membrane glycoprotein","level":3,"score":0.5194127559661865},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4435036778450012},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4304220676422119},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.4163168668746948},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38110822439193726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30756986141204834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30046671628952026},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.286870539188385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22592172026634216},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0545540452003479}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038981","descriptor_name":"Receptors, Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000340048","doi":"https://doi.org/10.1159/000340048","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000340048","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:22922528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22922528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:espace.curtin.edu.au:20.500.11937/8243","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11937/8243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401790","display_name":"eSpace (Curtin University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205640436","host_organization_name":"Curtin University","host_organization_lineage":["https://openalex.org/I205640436"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1535628758","https://openalex.org/W1552734957","https://openalex.org/W1857730116","https://openalex.org/W1972429479","https://openalex.org/W1972832497","https://openalex.org/W1973901090","https://openalex.org/W1984528197","https://openalex.org/W1992358929","https://openalex.org/W2006363406","https://openalex.org/W2009802325","https://openalex.org/W2011608330","https://openalex.org/W2016337873","https://openalex.org/W2017341404","https://openalex.org/W2022962025","https://openalex.org/W2027694261","https://openalex.org/W2030887495","https://openalex.org/W2045105401","https://openalex.org/W2048202003","https://openalex.org/W2061400583","https://openalex.org/W2065416929","https://openalex.org/W2065571808","https://openalex.org/W2067862448","https://openalex.org/W2068307892","https://openalex.org/W2073359373","https://openalex.org/W2073966706","https://openalex.org/W2080796596","https://openalex.org/W2081145901","https://openalex.org/W2090268921","https://openalex.org/W2095255852","https://openalex.org/W2117165617","https://openalex.org/W2125815072","https://openalex.org/W2130927645","https://openalex.org/W2133893126","https://openalex.org/W2156573675","https://openalex.org/W2157297879","https://openalex.org/W2157383269","https://openalex.org/W2158112997","https://openalex.org/W2165043805","https://openalex.org/W2165122118","https://openalex.org/W2171271044","https://openalex.org/W2265690186","https://openalex.org/W2313920324","https://openalex.org/W2993543892","https://openalex.org/W4321429627"],"related_works":["https://openalex.org/W2012515500","https://openalex.org/W1857730116","https://openalex.org/W2021156311","https://openalex.org/W6928891758","https://openalex.org/W4410001395","https://openalex.org/W2753385863","https://openalex.org/W2921849366","https://openalex.org/W1965314978","https://openalex.org/W2782482191","https://openalex.org/W2022962025"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Ligands":[1],"acting":[2],"at":[3],"the":[4,160],"platelet":[5,40,97,157,193],"collagen":[6,114],"receptor,":[7],"glycoprotein":[8],"(GP)VI,":[9],"induce":[10],"intracellular":[11,21,180],"FcR\u03b3/Syk-dependent":[12],"signaling":[13,44],"pathways":[14,30,60,190],"and":[15,43,65,76,87,99,139,159],"Syk-dependent":[16,145],"or":[17,28,115,147,188,195],"Syk-independent":[18,136],"generation":[19,64,79,138],"of":[20,35,39,74,162,165,184],"reactive":[22],"oxygen":[23],"species":[24],"(ROS).":[25],"Additional":[26],"signaling-dependent":[27],"signaling-independent":[29],"lead":[31],"to":[32,62,113,124,192],"metalloproteinase-mediated":[33],"shedding":[34,86],"GPVI.":[36],"AIM:":[37],"Analysis":[38],"GPVI":[41,75,85,100,130,141,175],"expression":[42,73,102],"in":[45,68,111,122,156,177],"a":[46,49,153],"patient":[47],"with":[48,53,128],"collagen-selective":[50],"defect":[51],"associated":[52],"myelodysplastic":[54],"syndrome":[55],"(MDS)":[56],"uniquely":[57],"demonstrates":[58],"divergent":[59,189],"leading":[61,191],"ROS":[63,78,137,146,181],"Syk":[66,88,168,186],"phosphorylation":[67,89,164],"human":[69],"platelets.":[70],"METHODS:":[71],"Surface":[72],"ligand-induced":[77,148,163],"was":[80],"quantitated":[81],"by":[82,92],"flow":[83],"cytometry.":[84],"were":[90],"analyzed":[91],"Western":[93],"blot.":[94],"RESULTS:":[95],"Despite":[96],"count/size":[98],"surface":[101],"within":[103],"normal":[104],"ranges,":[105],"platelet-rich":[106],"plasma":[107],"showed":[108,152],"no":[109],"aggregation":[110,194],"response":[112,123],"GPVI-selective":[116],"agonist":[117],"collagen-related":[118],"peptide,":[119],"but":[120,143],"aggregated":[121],"other":[125],"agonists,":[126],"consistent":[127],"dysfunctional":[129],"signaling.":[131],"We":[132],"observed":[133],"rapid":[134],"GPVI-dependent":[135],"disulfide-dependent":[140],"homodimerization,":[142],"not":[144],"shedding.":[149,197],"Temporal":[150],"analysis":[151],"gradual":[154],"decline":[155],"count":[158],"appearance":[161],"an":[166],"\u223c40-kDa":[167],"fragment.":[169],"CONCLUSIONS:":[170],"These":[171],"studies":[172],"show":[173],"that":[174],"ligation":[176],"platelets":[178],"induces":[179],"production":[182],"independent":[183],"either":[185],"activation":[187],"ectodomain":[196]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
