{"id":"https://openalex.org/W2002246578","doi":"https://doi.org/10.1088/0953-8984/16/26/014","title":"The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach","display_name":"The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach","publication_year":2004,"publication_date":"2004-06-19","ids":{"openalex":"https://openalex.org/W2002246578","doi":"https://doi.org/10.1088/0953-8984/16/26/014","mag":"2002246578"},"language":"en","primary_location":{"id":"doi:10.1088/0953-8984/16/26/014","doi":"https://doi.org/10.1088/0953-8984/16/26/014","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0953-8984/16/26/014","pdf_url":"https://iopscience.iop.org/article/10.1088/0953-8984/16/26/014/pdf","source":{"id":"https://openalex.org/S190924190","display_name":"Journal of Physics Condensed Matter","issn_l":"0953-8984","issn":["0953-8984","1361-648X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Condensed Matter","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iopscience.iop.org/article/10.1088/0953-8984/16/26/014/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007011762","display_name":"Frances Neville","orcid":"https://orcid.org/0000-0002-7760-1344","observed_orcids":["https://orcid.org/0000-0002-7760-1344"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frances Neville","raw_affiliation_strings":["Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032449755","display_name":"Marjolaine Cahuzac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marjolaine Cahuzac","raw_affiliation_strings":["Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088498945","display_name":"Andrew L. Nelson","orcid":"https://orcid.org/0000-0002-5842-7459","observed_orcids":["https://orcid.org/0000-0002-5842-7459"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Nelson","raw_affiliation_strings":["Centre for Self Organising Molecular Systems and School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK","Centre for Self Organising Molecular Systems and School of Chemistry, University of#N#Leeds, Leeds, LS2 9JT,#N#UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Self Organising Molecular Systems and School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Centre for Self Organising Molecular Systems and School of Chemistry, University of#N#Leeds, Leeds, LS2 9JT,#N#UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015223280","display_name":"David Gidalevitz","orcid":"https://orcid.org/0000-0002-3620-780X","observed_orcids":["https://orcid.org/0000-0002-3620-780X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I180949307","display_name":"Illinois Institute of Technology","ror":"https://ror.org/037t3ry66","country_code":"US","type":"education","lineage":["https://openalex.org/I180949307"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"David Gidalevitz","raw_affiliation_strings":["Department of Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA","Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","Department of Chemical and Environmental Engineering, Illinois Institute of Technology,#N#Chicago, IL 60616,#N#USA","Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA","institution_ids":["https://openalex.org/I180949307"]},{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Illinois Institute of Technology,#N#Chicago, IL 60616,#N#USA","institution_ids":["https://openalex.org/I180949307"]},{"raw_affiliation_string":"Institute for Materials Research and Department of Chemical Engineering, University of#N#Leeds, Leeds, LS2 9JT,#N#UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015223280"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I180949307"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":null,"fwci":1.8951,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83036815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"26","first_page":"S2413","last_page":"S2420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ll-37","display_name":"LL-37","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9779999852180481},{"id":"https://openalex.org/keywords/peptide-membrane-interactions","display_name":"peptide-membrane interactions","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lipid-monolayers","display_name":"lipid monolayers","score":0.9340000152587891},{"id":"https://openalex.org/keywords/air-water-interface","display_name":"air-water interface","score":0.7590000033378601},{"id":"https://openalex.org/keywords/phosphatidylglycerol","display_name":"phosphatidylglycerol","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lipid-a","display_name":"lipid A","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":1.0},{"id":"https://openalex.org/keywords/membrane-damage","display_name":"membrane damage","score":0.8299999833106995},{"id":"https://openalex.org/keywords/peptide-lipid-binding","display_name":"peptide-lipid binding","score":0.8190000057220459},{"id":"https://openalex.org/keywords/capacitance","display_name":"capacitance","score":0.6129999756813049},{"id":"https://openalex.org/keywords/layer-thickness","display_name":"layer thickness","score":0.6010000109672546},{"id":"https://openalex.org/keywords/epifluorescence-microscopy","display_name":"epifluorescence microscopy","score":0.781000018119812},{"id":"https://openalex.org/keywords/impedance-spectroscopy","display_name":"impedance spectroscopy","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.7986644506454468},{"id":"https://openalex.org/C7040849","wikidata":"https://www.wikidata.org/wiki/Q899580","display_name":"Dielectric spectroscopy","level":4,"score":0.6623497605323792},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6405407786369324},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5817083120346069},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5751504302024841},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.574368417263031},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.5584045648574829},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5233009457588196},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5062769651412964},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4967730641365051},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.41816478967666626},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.4133101999759674},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.41197073459625244},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.37217622995376587},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3265293538570404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.310377299785614},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2351132035255432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15127810835838318},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.13202261924743652},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/0953-8984/16/26/014","doi":"https://doi.org/10.1088/0953-8984/16/26/014","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0953-8984/16/26/014","pdf_url":"https://iopscience.iop.org/article/10.1088/0953-8984/16/26/014/pdf","source":{"id":"https://openalex.org/S190924190","display_name":"Journal of Physics Condensed Matter","issn_l":"0953-8984","issn":["0953-8984","1361-648X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Condensed Matter","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/0953-8984/16/26/014","doi":"https://doi.org/10.1088/0953-8984/16/26/014","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0953-8984/16/26/014","pdf_url":"https://iopscience.iop.org/article/10.1088/0953-8984/16/26/014/pdf","source":{"id":"https://openalex.org/S190924190","display_name":"Journal of Physics Condensed Matter","issn_l":"0953-8984","issn":["0953-8984","1361-648X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Condensed Matter","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002246578.pdf","grobid_xml":"https://content.openalex.org/works/W2002246578.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W41822333","https://openalex.org/W1565259073","https://openalex.org/W1623183061","https://openalex.org/W1979192175","https://openalex.org/W2002066211","https://openalex.org/W2003493354","https://openalex.org/W2017600594","https://openalex.org/W2020154280","https://openalex.org/W2025230440","https://openalex.org/W2026165865","https://openalex.org/W2027820702","https://openalex.org/W2030716883","https://openalex.org/W2041787682","https://openalex.org/W2047599457","https://openalex.org/W2054602599","https://openalex.org/W2063312972","https://openalex.org/W2081539900","https://openalex.org/W2081973476","https://openalex.org/W2082790072","https://openalex.org/W2082844643","https://openalex.org/W2084954530","https://openalex.org/W2090279224","https://openalex.org/W2092658336","https://openalex.org/W2096283909","https://openalex.org/W2138893502","https://openalex.org/W2473637287","https://openalex.org/W4232495602","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3160239680","https://openalex.org/W1964113525","https://openalex.org/W2913537512","https://openalex.org/W1971163616","https://openalex.org/W2049814814","https://openalex.org/W2016956807","https://openalex.org/W4393278996","https://openalex.org/W2795459631","https://openalex.org/W2805124267","https://openalex.org/W2114526613"],"abstract_inverted_index":{"Membrane":[0],"interactions":[1],"of":[2,14,28,63],"the":[3,32,61,85],"human":[4],"antimicrobial":[5],"peptide":[6],"LL-37":[7,45,86,95],"have":[8],"been":[9],"studied":[10],"by":[11,70],"a":[12],"variety":[13],"techniques":[15],"including":[16],"insertion":[17],"assay,":[18],"epifluorescence":[19,77],"microscopy":[20],"and":[21,51,78],"impedance":[22],"spectroscopy.":[23],"This":[24],"study":[25],"makes":[26],"use":[27],"lipid":[29,52,97],"monolayers":[30,66],"at":[31],"air\u2013aqueous":[33],"interface":[34],"to":[35],"mimic":[36],"bacterial":[37],"or":[38],"eukaryotic":[39],"membranes.":[40],"It":[41],"was":[42],"found":[43],"that":[44,84],"readily":[46],"inserts":[47],"into":[48],"phosphatidylglycerol":[49],"(PG)":[50],"A":[53,98],"monolayers,":[54],"significantly":[55],"disrupting":[56],"their":[57],"structure.":[58],"In":[59],"contrast,":[60],"structure":[62],"phosphatidylcholine":[64],"(PC)":[65],"remains":[67,90],"virtually":[68],"unaffected":[69],"LL-37,":[71],"which":[72],"is":[73],"evident":[74],"both":[75],"from":[76,108],"electrochemical":[79],"measurements.":[80],"Impedance":[81],"spectroscopy":[82],"showed":[83],"rich":[87],"PC":[88],"monolayer":[89],"an":[91,103],"ideal":[92],"capacitor":[93],"while":[94],"enriched":[96],"capacitance":[99],"decreases":[100],"significantly,":[101],"suggesting":[102],"increase":[104],"in":[105],"layer":[106],"thickness":[107],"peptide\u2013lipid":[109],"binding.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}