{"id":"https://openalex.org/W2002245039","doi":"https://doi.org/10.1016/j.bbmt.2008.10.010","title":"Oncogenic Signals as Treatment Targets in Classic Myeloproliferative Neoplasms","display_name":"Oncogenic Signals as Treatment Targets in Classic Myeloproliferative Neoplasms","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2002245039","doi":"https://doi.org/10.1016/j.bbmt.2008.10.010","mag":"2002245039","pmid":"https://pubmed.ncbi.nlm.nih.gov/19147089"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbmt.2008.10.010","doi":"https://doi.org/10.1016/j.bbmt.2008.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2008.10.010","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbmt.2008.10.010","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016216479","display_name":"Ayalew Tefferi","orcid":"https://orcid.org/0000-0003-4605-3821","observed_orcids":["https://orcid.org/0000-0003-4605-3821"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ayalew Tefferi","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, USA","Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025660159","display_name":"Ross L. Levine","orcid":"https://orcid.org/0000-0002-7884-1905","observed_orcids":["https://orcid.org/0000-0002-7884-1905"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross L. Levine","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, New York","Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop Kantarjian","raw_affiliation_strings":["MD Anderson\u00a0Cancer Center, Houston, Texas","MD Anderson Cancer Center , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson\u00a0Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"MD Anderson Cancer Center , Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016216479"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.4339,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66989127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"1","first_page":"114","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.996999979019165},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8029999732971191},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.7350000143051147},{"id":"https://openalex.org/keywords/fip1l1-pdgfra-fusion","display_name":"FIP1L1-PDGFRA fusion","score":0.9509999752044678},{"id":"https://openalex.org/keywords/jak2-mutation","display_name":"JAK2 mutation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mpl-mutation","display_name":"MPL mutation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kit-d816v-mutation","display_name":"KIT D816V mutation","score":0.902999997138977},{"id":"https://openalex.org/keywords/fgfr1-rearrangement","display_name":"FGFR1 rearrangement","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":1.0},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/systemic-mastocytosis","display_name":"systemic mastocytosis","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.8544565439224243},{"id":"https://openalex.org/C78221974","wikidata":"https://www.wikidata.org/wiki/Q18030425","display_name":"PDGFRB","level":3,"score":0.8285768032073975},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.7798895835876465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7751182317733765},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.6744546890258789},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6665217876434326},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.6301034092903137},{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.6135441064834595},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5464873909950256},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5111525654792786},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4968610107898712},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.4797852635383606},{"id":"https://openalex.org/C2780829020","wikidata":"https://www.wikidata.org/wiki/Q408163","display_name":"Anagrelide","level":4,"score":0.4594358801841736},{"id":"https://openalex.org/C2483381","wikidata":"https://www.wikidata.org/wiki/Q18030194","display_name":"NPM1","level":5,"score":0.4519306719303131},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.4488990306854248},{"id":"https://openalex.org/C2780833115","wikidata":"https://www.wikidata.org/wiki/Q14914527","display_name":"ETV6","level":4,"score":0.4245941936969757},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2202901840209961},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.21722382307052612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2075718343257904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13996240496635437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10799944400787354},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.10293787717819214},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.08033552765846252},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.06125786900520325},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.0},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbmt.2008.10.010","doi":"https://doi.org/10.1016/j.bbmt.2008.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2008.10.010","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},{"id":"pmid:19147089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19147089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbmt.2008.10.010","doi":"https://doi.org/10.1016/j.bbmt.2008.10.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2008.10.010","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W161996477","https://openalex.org/W186063976","https://openalex.org/W344393255","https://openalex.org/W1490860457","https://openalex.org/W1510546584","https://openalex.org/W1510874774","https://openalex.org/W1965375035","https://openalex.org/W1967919154","https://openalex.org/W1970553871","https://openalex.org/W1971248653","https://openalex.org/W1972112588","https://openalex.org/W1976479449","https://openalex.org/W1978187390","https://openalex.org/W1978330466","https://openalex.org/W1980568348","https://openalex.org/W1983650558","https://openalex.org/W1983892731","https://openalex.org/W1987362547","https://openalex.org/W1987470267","https://openalex.org/W1987925274","https://openalex.org/W1987966047","https://openalex.org/W1988019098","https://openalex.org/W1990250202","https://openalex.org/W1994309500","https://openalex.org/W1994830891","https://openalex.org/W1995578813","https://openalex.org/W1995930366","https://openalex.org/W1996189576","https://openalex.org/W1996683133","https://openalex.org/W1997560018","https://openalex.org/W1998593414","https://openalex.org/W1999608888","https://openalex.org/W2001006614","https://openalex.org/W2002117801","https://openalex.org/W2006468333","https://openalex.org/W2006518962","https://openalex.org/W2008198456","https://openalex.org/W2010268883","https://openalex.org/W2011346454","https://openalex.org/W2011474502","https://openalex.org/W2012952884","https://openalex.org/W2015015957","https://openalex.org/W2016086822","https://openalex.org/W2017021967","https://openalex.org/W2017410022","https://openalex.org/W2020092689","https://openalex.org/W2022750639","https://openalex.org/W2023815964","https://openalex.org/W2023942015","https://openalex.org/W2026644362","https://openalex.org/W2029466025","https://openalex.org/W2029818817","https://openalex.org/W2036047439","https://openalex.org/W2038195476","https://openalex.org/W2039285688","https://openalex.org/W2042011247","https://openalex.org/W2046632940","https://openalex.org/W2047079894","https://openalex.org/W2048394134","https://openalex.org/W2049145190","https://openalex.org/W2050477487","https://openalex.org/W2050596106","https://openalex.org/W2052475832","https://openalex.org/W2053310263","https://openalex.org/W2053846867","https://openalex.org/W2054251966","https://openalex.org/W2056777053","https://openalex.org/W2057360098","https://openalex.org/W2057375535","https://openalex.org/W2060833726","https://openalex.org/W2061956129","https://openalex.org/W2064698668","https://openalex.org/W2067700234","https://openalex.org/W2075216432","https://openalex.org/W2075970562","https://openalex.org/W2076372887","https://openalex.org/W2078038866","https://openalex.org/W2078391398","https://openalex.org/W2078398386","https://openalex.org/W2086998336","https://openalex.org/W2089483984","https://openalex.org/W2092606584","https://openalex.org/W2094457899","https://openalex.org/W2101502003","https://openalex.org/W2103974518","https://openalex.org/W2104043831","https://openalex.org/W2104485296","https://openalex.org/W2107268345","https://openalex.org/W2108771181","https://openalex.org/W2111914345","https://openalex.org/W2116878961","https://openalex.org/W2126665281","https://openalex.org/W2131067167","https://openalex.org/W2131174104","https://openalex.org/W2133804552","https://openalex.org/W2134094496","https://openalex.org/W2136903358","https://openalex.org/W2141349162","https://openalex.org/W2142969636","https://openalex.org/W2143877481","https://openalex.org/W2144198294","https://openalex.org/W2144651412","https://openalex.org/W2144664431","https://openalex.org/W2146505525","https://openalex.org/W2151486690","https://openalex.org/W2154591898","https://openalex.org/W2155469435","https://openalex.org/W2156482024","https://openalex.org/W2156694334","https://openalex.org/W2159962994","https://openalex.org/W2162013503","https://openalex.org/W2169452890","https://openalex.org/W2169501631","https://openalex.org/W2171722798","https://openalex.org/W2275311108","https://openalex.org/W2303212700","https://openalex.org/W2312804644","https://openalex.org/W2329648702","https://openalex.org/W2408843338","https://openalex.org/W2491446616","https://openalex.org/W2552564416","https://openalex.org/W2554871388","https://openalex.org/W2572005875","https://openalex.org/W4285719527","https://openalex.org/W6629364043","https://openalex.org/W6729870333","https://openalex.org/W6730143759","https://openalex.org/W6731757824"],"related_works":["https://openalex.org/W2239990123","https://openalex.org/W2045905423","https://openalex.org/W2059637742","https://openalex.org/W1573974756","https://openalex.org/W2082030723","https://openalex.org/W2295599767","https://openalex.org/W2810615447","https://openalex.org/W3128066466","https://openalex.org/W1993479562","https://openalex.org/W2576708678"],"abstract_inverted_index":{"Therapeutically":[0],"validated":[1],"oncoproteins":[2],"in":[3,9,48,64,85,94],"myeloproliferative":[4],"neoplasms":[5],"(MPNs)":[6],"include":[7,43],"BCR-ABL":[8],"chronic":[10],"myelogenous":[11],"leukemia":[12],"(CML)":[13],"and":[14,45,55,60,67,92],"a":[15],"spectrum":[16],"of":[17,24,83,97],"PDGFRA/B":[18],"mutant":[19,81],"proteins":[20],"that":[21,38],"are":[22,39],"products":[23],"intra-":[25],"(eg,":[26,30],"FIP1L1-PDGFRA)":[27],"or":[28],"interchromosomal":[29],"ETV6-PDGFRB)":[31],"gene":[32],"fusions.":[33],"Other":[34],"MPN-relevant":[35],"putative":[36],"oncogenes":[37],"awaiting":[40],"therapeutic":[41],"validation,":[42],"JAK2":[44],"MPL":[46],"mutations":[47,63],"polycythemia":[49],"vera":[50],"(PV),":[51],"essential":[52],"thrombocythemia":[53],"(ET),":[54],"primary":[56],"myelofibrosis":[57],"(PMF);":[58],"KITD816V":[59],"other":[61],"KIT":[62],"systemic":[65],"mastocytosis,":[66],"FGFR1":[68],"rearrangements":[69],"associated":[70],"with":[71],"the":[72,95],"8p11":[73],"leukemia/lymphoma":[74],"syndrome.":[75],"The":[76],"current":[77],"review":[78],"focuses":[79],"on":[80],"molecules":[82],"interest":[84],"classic":[86],"MPNs":[87],"(ie,":[88],"CML,":[89],"PV,":[90],"ET,":[91],"PMF)":[93],"context":[96],"their":[98],"value":[99],"as":[100],"drug":[101],"targets.":[102]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}