{"id":"https://openalex.org/W2002243556","doi":"https://doi.org/10.1007/s10974-010-9231-8","title":"More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease","display_name":"More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2002243556","doi":"https://doi.org/10.1007/s10974-010-9231-8","mag":"2002243556","pmid":"https://pubmed.ncbi.nlm.nih.gov/21132354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3005110"},"language":"en","primary_location":{"id":"doi:10.1007/s10974-010-9231-8","doi":"https://doi.org/10.1007/s10974-010-9231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10974-010-9231-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10974-010-9231-8.pdf","source":{"id":"https://openalex.org/S122159434","display_name":"Journal of Muscle Research and Cell Motility","issn_l":"0142-4319","issn":["0142-4319","1573-2657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Muscle Research and Cell Motility","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10974-010-9231-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002233320","display_name":"Nazha Hamdani","orcid":"https://orcid.org/0000-0002-3053-0008","observed_orcids":["https://orcid.org/0000-0002-3053-0008"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nazha Hamdani","raw_affiliation_strings":["Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103099830","display_name":"Attila Borb\u00e9ly","orcid":"https://orcid.org/0000-0002-6019-6274","observed_orcids":["https://orcid.org/0000-0002-6019-6274"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Attila Borb\u00e9ly","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108323918","display_name":"S. Veenstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sophie P. G. R. Veenstra","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031256057","display_name":"Viola Kooij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Viola Kooij","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056725548","display_name":"Wim Vrydag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wim Vrydag","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","University of Amsterdam#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"University of Amsterdam#N#","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052629322","display_name":"R. Zaremba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ruud Zaremba","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007866499","display_name":"Cristobal G. dos Remedios","orcid":"https://orcid.org/0000-0003-1052-7490","observed_orcids":["https://orcid.org/0000-0003-1052-7490"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cris dos Remedios","raw_affiliation_strings":["Muscle Research Unit, Institute for Biomedical Research, The University of Sydney, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muscle Research Unit, Institute for Biomedical Research, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065784242","display_name":"Hans W.M. Niessen","orcid":"https://orcid.org/0000-0001-9404-9822","observed_orcids":["https://orcid.org/0000-0001-9404-9822"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans W. M. Niessen","raw_affiliation_strings":["Department of Pathology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040869371","display_name":"Martin Christian Michel","orcid":"https://orcid.org/0000-0003-4161-8467","observed_orcids":["https://orcid.org/0000-0003-4161-8467"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin C. Michel","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","University of Amsterdam#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"University of Amsterdam#N#","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016743789","display_name":"Walter J. Paulus","orcid":"https://orcid.org/0000-0002-1597-1737","observed_orcids":["https://orcid.org/0000-0002-1597-1737"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Walter J. Paulus","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019586059","display_name":"Ger J.M. Stienen","orcid":"https://orcid.org/0000-0001-5829-0328","observed_orcids":["https://orcid.org/0000-0001-5829-0328"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ger J. M. Stienen","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008468085","display_name":"Jolanda van der Velden","orcid":"https://orcid.org/0000-0001-5224-5788","observed_orcids":["https://orcid.org/0000-0001-5224-5788"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jolanda van der Velden","raw_affiliation_strings":["Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008468085"],"corresponding_institution_ids":["https://openalex.org/I4405257531","https://openalex.org/I911458345"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":2.1408,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.88049839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"4","first_page":"289","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-dilated-cardiomyopathy","display_name":"idiopathic dilated cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8550000190734863},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinases","display_name":"G protein-coupled receptor kinases","score":0.7789999842643738},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/protein-phosphatase-1","display_name":"protein phosphatase 1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":0.9900000095367432},{"id":"https://openalex.org/keywords/serca2a","display_name":"SERCA2a","score":1.0},{"id":"https://openalex.org/keywords/myocyte-contractility","display_name":"myocyte contractility","score":0.890999972820282},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7129999995231628},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.656000018119812},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.8814365267753601},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.8726226091384888},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6821179389953613},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6600341796875},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.6055305004119873},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.571068286895752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5627561807632446},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5295180678367615},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5138149857521057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46141064167022705},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4568714201450348},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45063087344169617},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43306198716163635},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.41610413789749146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35325390100479126},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33847081661224365},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3258839249610901}],"mesh":[{"descriptor_ui":"D000099211","descriptor_name":"Phospholamban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1007/s10974-010-9231-8","doi":"https://doi.org/10.1007/s10974-010-9231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10974-010-9231-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10974-010-9231-8.pdf","source":{"id":"https://openalex.org/S122159434","display_name":"Journal of Muscle Research and Cell Motility","issn_l":"0142-4319","issn":["0142-4319","1573-2657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Muscle Research and Cell Motility","raw_type":"journal-article"},{"id":"pmid:21132354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21132354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of muscle research and cell motility","raw_type":"Comparative Study"},{"id":"pmh:oai:dare.uva.nl:openaire/638128b3-20de-47ac-a6f1-9c06bc98f2db","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/more-severe-cellular-phenotype-in-human-idiopathic-dilated-cardiomyopathy-compared-to-ischemic-heart-disease(638128b3-20de-47ac-a6f1-9c06bc98f2db).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hamdani, N, Borb\u00e9ly, A, Veenstra, S P G R, Kooij, V, Vrydag, W, Zaremba, R, dos Remedios, C, Niessen, H W M, Michel, M C, Paulus, W J, Stienen, G J M & van der Velden, J 2010, 'More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease', Journal of Muscle Research and Cell Motility, vol. 31, no. 4, pp. 289-301. https://doi.org/10.1007/s10974-010-9231-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3005110","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3005110/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Muscle Res Cell Motil","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/5299a1ae-b28b-4ebf-95cd-4ae2016b91f9","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/5299a1ae-b28b-4ebf-95cd-4ae2016b91f9","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hamdani, N, Borb\u00e9ly, A, Veenstra, S P G R, Kooij, V, Vrydag, W, Zaremba, R, dos Remedios, C, Niessen, H W M, Michel, M C, Paulus, W J, Stienen, G J M & van der Velden, J 2010, 'More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease', Journal of muscle research and cell motility, vol. 31, no. 4, pp. 289-301. https://doi.org/10.1007/s10974-010-9231-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/34804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/34804","pdf_url":"http://hdl.handle.net/1871/34804","source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"31","raw_type":"Article / Letter to editor"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/820c51f3-4356-43a6-85e2-962d55157af7","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/more-severe-cellular-phenotype-in-human-idiopathic-dilated-cardiomyopathy-compared-to-ischemic-heart-disease(820c51f3-4356-43a6-85e2-962d55157af7).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of muscle research and cell motility, 31(4), 289 - 301. Springer Netherlands","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dea.lib.unideb.hu:2437/104211","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1007/s10974-010-9231-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"foly\u00f3iratcikk"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/104211","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/104211","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/638128b3-20de-47ac-a6f1-9c06bc98f2db","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/more-severe-cellular-phenotype-in-human-idiopathic-dilated-cardiomyopathy-compared-to-ischemic-heart-disease(638128b3-20de-47ac-a6f1-9c06bc98f2db).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Muscle Research and Cell Motility, 31(4), 289 - 301. Springer Netherlands","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu2:oai:dare.ubvu.vu.nl:1871/34804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/34804","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Muscle Research and Cell Motility, 31(4), 289","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/fbd03e52-29e8-4776-bc5b-063b654d2e67","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/fbd03e52-29e8-4776-bc5b-063b654d2e67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Muscle Research and Cell Motility, 31(4), 289 - 301. Springer Netherlands","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2189131206","doi":null,"is_oa":false,"landing_page_url":"http://dare.uva.nl/document/2/94606","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/s10974-010-9231-8","doi":"https://doi.org/10.1007/s10974-010-9231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10974-010-9231-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10974-010-9231-8.pdf","source":{"id":"https://openalex.org/S122159434","display_name":"Journal of Muscle Research and Cell Motility","issn_l":"0142-4319","issn":["0142-4319","1573-2657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Muscle Research and Cell Motility","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002243556.pdf","grobid_xml":"https://content.openalex.org/works/W2002243556.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W91862947","https://openalex.org/W1492554664","https://openalex.org/W1948948667","https://openalex.org/W1964747697","https://openalex.org/W1967132920","https://openalex.org/W1971751212","https://openalex.org/W1973383826","https://openalex.org/W1978063892","https://openalex.org/W1988989702","https://openalex.org/W1991686835","https://openalex.org/W1997022909","https://openalex.org/W2014534876","https://openalex.org/W2017639799","https://openalex.org/W2020563127","https://openalex.org/W2031203524","https://openalex.org/W2050313711","https://openalex.org/W2050824263","https://openalex.org/W2056840703","https://openalex.org/W2058581105","https://openalex.org/W2068759620","https://openalex.org/W2074631079","https://openalex.org/W2081442441","https://openalex.org/W2082823804","https://openalex.org/W2094065595","https://openalex.org/W2100989502","https://openalex.org/W2106909429","https://openalex.org/W2106988800","https://openalex.org/W2122760939","https://openalex.org/W2122991452","https://openalex.org/W2129930339","https://openalex.org/W2135302420","https://openalex.org/W2139645827","https://openalex.org/W2140058582","https://openalex.org/W2140732346","https://openalex.org/W2147220948","https://openalex.org/W2149239576","https://openalex.org/W2153195779","https://openalex.org/W2154605694","https://openalex.org/W2162418013","https://openalex.org/W2165786593","https://openalex.org/W2168324813","https://openalex.org/W2278922750","https://openalex.org/W2338638760","https://openalex.org/W4249442256","https://openalex.org/W6979097523"],"related_works":["https://openalex.org/W2189131206","https://openalex.org/W6990561387","https://openalex.org/W69779101","https://openalex.org/W1997541816","https://openalex.org/W1963668975","https://openalex.org/W2412197207","https://openalex.org/W4387675987","https://openalex.org/W324398358","https://openalex.org/W2122180603","https://openalex.org/W2399225612"],"abstract_inverted_index":{"Activation":[0],"of":[1,11,24,48,50,100,103,120,126,130],"the":[2,8,12,40,51,84,117,128,152],"\u03b2-adrenergic":[3],"receptor":[4,90],"(\u03b2AR)":[5],"pathway":[6,154],"is":[7,180],"main":[9],"mechanism":[10],"heart":[13,37,121],"to":[14,33,76,148],"increase":[15],"cardiac":[16,34,57],"output":[17],"via":[18],"protein":[19,105,170],"kinase":[20],"A":[21],"(PKA)-mediated":[22],"phosphorylation":[23,99],"cellular":[25,169,178],"target":[26],"proteins,":[27],"and":[28,56,67,93,96,110,163,172],"perturbations":[29],"therein":[30],"may":[31,164],"contribute":[32],"dysfunction":[35,179],"in":[36,59,74,134,137,145,151,158,161,168,183,186],"failure.":[38],"In":[39],"present":[41],"study":[42],"a":[43],"comprehensive":[44],"analysis":[45,140],"was":[46,132],"made":[47],"mediators":[49],"\u03b2AR":[52,87,153],"pathway,":[53],"myofilament":[54,101],"properties":[55],"structure":[58],"patients":[60],"with":[61],"idiopathic":[62],"(IDCM;":[63],"n":[64,70,80],"=":[65,71,81],"13)":[66],"ischemic":[68],"(ISHD;":[69],"10)":[72,82],"cardiomyopathy":[73],"comparison":[75],"non-failing":[77],"hearts":[78],"(donor;":[79],"for":[83,124],"following":[85],"parameters:":[86],"density,":[88],"G-coupled":[89],"kinases":[91],"2":[92],"5,":[94],"stimulatory":[95],"inhibitory":[97],"G-proteins,":[98],"targets":[102],"PKA,":[104],"phosphatase":[106],"1,":[107],"phospholamban,":[108],"SERCA2a":[109],"single":[111],"myocyte":[112],"contractility.":[113],"All":[114],"parameters":[115],"exhibited":[116],"expected":[118],"alterations":[119],"failure,":[122],"but":[123],"most":[125],"them":[127],"extent":[129],"alteration":[131],"greater":[133],"IDCM":[135,146,159,184],"than":[136,160,185],"ISHD.":[138,149,187],"Histological":[139],"also":[141],"revealed":[142],"higher":[143],"collagen":[144],"compared":[147],"Alterations":[150],"are":[155],"more":[156,181],"pronounced":[157],"ISHD":[162],"reflect":[165],"sequential":[166],"changes":[167],"composition":[171],"function.":[173],"Our":[174],"data":[175],"indicate":[176],"that":[177],"severe":[182]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}