{"id":"https://openalex.org/W2002242108","doi":"https://doi.org/10.1016/0022-2836(86)90239-1","title":"Organization and evolution of variable region genes of the human immunoglobulin heavy chain","display_name":"Organization and evolution of variable region genes of the human immunoglobulin heavy chain","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W2002242108","doi":"https://doi.org/10.1016/0022-2836(86)90239-1","mag":"2002242108","pmid":"https://pubmed.ncbi.nlm.nih.gov/3097326"},"language":"en","primary_location":{"id":"doi:10.1016/0022-2836(86)90239-1","doi":"https://doi.org/10.1016/0022-2836(86)90239-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(86)90239-1","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083545024","display_name":"Mieko Kodaira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mieko Kodaira","raw_affiliation_strings":["Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023661305","display_name":"Tatsuo Kinashi","orcid":"https://orcid.org/0000-0002-1286-6608","observed_orcids":["https://orcid.org/0000-0002-1286-6608"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Kinashi","raw_affiliation_strings":["Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Isao Umemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Umemura","raw_affiliation_strings":["Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042371436","display_name":"Fumihiko Matsuda","orcid":"https://orcid.org/0000-0003-4557-4553","observed_orcids":["https://orcid.org/0000-0003-4557-4553"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiko Matsuda","raw_affiliation_strings":["Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007002203","display_name":"Takafumi Noma","orcid":"https://orcid.org/0000-0001-6072-3217","observed_orcids":["https://orcid.org/0000-0001-6072-3217"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Noma","raw_affiliation_strings":["Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089784647","display_name":"Yasushi Ono","orcid":"https://orcid.org/0000-0002-9941-5833","observed_orcids":["https://orcid.org/0000-0002-9941-5833"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Ono","raw_affiliation_strings":["Department of Microbiology Nihon University School of Medicine Itabashi, Tokyo 173, Japan","Nihon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Nihon University School of Medicine Itabashi, Tokyo 173, Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Nihon University","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019039647","display_name":"Tasuku Honjo","orcid":"https://orcid.org/0000-0003-2300-3928","observed_orcids":["https://orcid.org/0000-0003-2300-3928"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tasuku Honjo","raw_affiliation_strings":["Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":9.0441,"has_fulltext":false,"cited_by_count":219,"citation_normalized_percentile":{"value":0.98589257,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"190","issue":"4","first_page":"529","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.15209999680519104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-immunoglobulin","display_name":"human immunoglobulin","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cosmid-clones","display_name":"cosmid clones","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pseudogenes","display_name":"pseudogenes","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hypervariable-region","display_name":"hypervariable region","score":0.9660000205039978},{"id":"https://openalex.org/keywords/synonymous-mutations","display_name":"synonymous mutations","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.9620070457458496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7909553050994873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7412769198417664},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.6955345869064331},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6907864809036255},{"id":"https://openalex.org/C35101798","wikidata":"https://www.wikidata.org/wiki/Q414491","display_name":"Cosmid","level":3,"score":0.6687970161437988},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4477154314517975},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.4446389675140381},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.4251865744590759},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33634746074676514},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.17977949976921082}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-2836(86)90239-1","doi":"https://doi.org/10.1016/0022-2836(86)90239-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(86)90239-1","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:3097326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3097326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W221933387","https://openalex.org/W1026356141","https://openalex.org/W1601687245","https://openalex.org/W1890864310","https://openalex.org/W1970581401","https://openalex.org/W1974596630","https://openalex.org/W1974884008","https://openalex.org/W1975868741","https://openalex.org/W1979914089","https://openalex.org/W1984387553","https://openalex.org/W1985042354","https://openalex.org/W1986059203","https://openalex.org/W2001187632","https://openalex.org/W2007647936","https://openalex.org/W2014549199","https://openalex.org/W2016225921","https://openalex.org/W2019410656","https://openalex.org/W2028622989","https://openalex.org/W2028954926","https://openalex.org/W2030616232","https://openalex.org/W2030620813","https://openalex.org/W2030696171","https://openalex.org/W2045402478","https://openalex.org/W2049635421","https://openalex.org/W2054468433","https://openalex.org/W2059897736","https://openalex.org/W2063450941","https://openalex.org/W2063516905","https://openalex.org/W2064421628","https://openalex.org/W2069932486","https://openalex.org/W2074596664","https://openalex.org/W2085369521","https://openalex.org/W2118602822","https://openalex.org/W2120513063","https://openalex.org/W2122385641","https://openalex.org/W2127552260","https://openalex.org/W2395912144","https://openalex.org/W2578150941","https://openalex.org/W2762374987","https://openalex.org/W4243211091"],"related_works":["https://openalex.org/W2041309682","https://openalex.org/W2038624224","https://openalex.org/W2008713578","https://openalex.org/W2265893993","https://openalex.org/W2040571417","https://openalex.org/W2021888897","https://openalex.org/W1972884489","https://openalex.org/W61551963","https://openalex.org/W2074672837","https://openalex.org/W2064836402"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}