{"id":"https://openalex.org/W2002201041","doi":"https://doi.org/10.1007/s00441-011-1321-4","title":"Dynamics of expression patterns of AQP4, dystroglycan, agrin and matrix metalloproteinases in human glioblastoma","display_name":"Dynamics of expression patterns of AQP4, dystroglycan, agrin and matrix metalloproteinases in human glioblastoma","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2002201041","doi":"https://doi.org/10.1007/s00441-011-1321-4","mag":"2002201041","pmid":"https://pubmed.ncbi.nlm.nih.gov/22307776"},"language":"en","primary_location":{"id":"doi:10.1007/s00441-011-1321-4","doi":"https://doi.org/10.1007/s00441-011-1321-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00441-011-1321-4","pdf_url":null,"source":{"id":"https://openalex.org/S139399906","display_name":"Cell and Tissue Research","issn_l":"0302-766X","issn":["0302-766X","1432-0878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027241562","display_name":"Susan Noell","orcid":"https://orcid.org/0000-0002-2433-0990","observed_orcids":["https://orcid.org/0000-0002-2433-0990"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susan Noell","raw_affiliation_strings":["Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036672174","display_name":"Karen Wolburg\u2010Buchholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Wolburg-Buchholz","raw_affiliation_strings":["Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081286371","display_name":"Andreas F. Mack","orcid":"https://orcid.org/0000-0001-7591-4374","observed_orcids":["https://orcid.org/0000-0001-7591-4374"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas F. Mack","raw_affiliation_strings":["Institute of Anatomy, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030845336","display_name":"Rainer Ritz","orcid":"https://orcid.org/0000-0003-1072-5614","observed_orcids":["https://orcid.org/0000-0003-1072-5614"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Ritz","raw_affiliation_strings":["Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044195004","display_name":"Marcos Soares Tatagiba","orcid":"https://orcid.org/0000-0002-1627-9937","observed_orcids":["https://orcid.org/0000-0002-1627-9937"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcos Tatagiba","raw_affiliation_strings":["Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056320938","display_name":"Rudi Beschorner","orcid":"https://orcid.org/0000-0003-1109-915X","observed_orcids":["https://orcid.org/0000-0003-1109-915X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rudi Beschorner","raw_affiliation_strings":["Department of Neuropathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578984","display_name":"Hartwig Wolburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hartwig Wolburg","raw_affiliation_strings":["Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany","Institute of Pathology and Neuropathology, Liebermeisterstra\u00dfe 8, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Institute of Pathology and Neuropathology, Liebermeisterstra\u00dfe 8, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037227734","display_name":"Petra Fallier\u2010Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Fallier-Becker","raw_affiliation_strings":["Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Pathology and Neuropathology, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111578984"],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":1.6798,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.83244187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"347","issue":"2","first_page":"429","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.18230000138282776,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dystroglycan","display_name":"dystroglycan","score":0.9919999837875366},{"id":"https://openalex.org/keywords/agrin","display_name":"agrin","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.984000027179718},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7170000076293945},{"id":"https://openalex.org/keywords/orthogonal-arrays-of-particles","display_name":"orthogonal arrays of particles","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neurovascular-unit","display_name":"neurovascular unit","score":0.7860000133514404},{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779024559","wikidata":"https://www.wikidata.org/wiki/Q4694120","display_name":"Agrin","level":4,"score":0.9301548004150391},{"id":"https://openalex.org/C2778384963","wikidata":"https://www.wikidata.org/wiki/Q5319588","display_name":"Dystroglycan","level":4,"score":0.9224300384521484},{"id":"https://openalex.org/C2779295440","wikidata":"https://www.wikidata.org/wiki/Q21114943","display_name":"MMP3","level":4,"score":0.6903373003005981},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6682883501052856},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6341440081596375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5538418292999268},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.49856090545654297},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.4941847622394562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4251802861690521},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.4251704812049866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3893265724182129},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36713534593582153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3378838002681732},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.30307090282440186},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21006375551223755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18435943126678467},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.1769990622997284},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15672263503074646},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.1505732536315918},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1458505392074585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10247883200645447},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0955902636051178}],"mesh":[{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005614","descriptor_name":"Freeze Fracturing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018171","descriptor_name":"Agrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049030","descriptor_name":"Dystroglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051401","descriptor_name":"Aquaporin 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00441-011-1321-4","doi":"https://doi.org/10.1007/s00441-011-1321-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00441-011-1321-4","pdf_url":null,"source":{"id":"https://openalex.org/S139399906","display_name":"Cell and Tissue Research","issn_l":"0302-766X","issn":["0302-766X","1432-0878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Research","raw_type":"journal-article"},{"id":"pmid:22307776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22307776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and tissue research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W269137301","https://openalex.org/W1570470449","https://openalex.org/W1638810975","https://openalex.org/W1800142641","https://openalex.org/W1907633885","https://openalex.org/W1968754528","https://openalex.org/W1970242454","https://openalex.org/W1979139869","https://openalex.org/W1979787653","https://openalex.org/W1987177757","https://openalex.org/W1988296977","https://openalex.org/W1991680358","https://openalex.org/W1995300477","https://openalex.org/W1996123970","https://openalex.org/W1997788188","https://openalex.org/W2003726414","https://openalex.org/W2005675003","https://openalex.org/W2006740852","https://openalex.org/W2009059228","https://openalex.org/W2015065886","https://openalex.org/W2024661673","https://openalex.org/W2024872254","https://openalex.org/W2033966887","https://openalex.org/W2041600167","https://openalex.org/W2046678465","https://openalex.org/W2052322755","https://openalex.org/W2057974205","https://openalex.org/W2064713490","https://openalex.org/W2083336965","https://openalex.org/W2089679794","https://openalex.org/W2096287682","https://openalex.org/W2104577276","https://openalex.org/W2120334927","https://openalex.org/W2121525722","https://openalex.org/W2121983458","https://openalex.org/W2124054487","https://openalex.org/W2128635872","https://openalex.org/W2146369085","https://openalex.org/W2146976930","https://openalex.org/W2154746168","https://openalex.org/W2154793195","https://openalex.org/W2158681922","https://openalex.org/W2485386989","https://openalex.org/W4249698304"],"related_works":["https://openalex.org/W1996123970","https://openalex.org/W2150371702","https://openalex.org/W1967670281","https://openalex.org/W4416169799","https://openalex.org/W2138812985","https://openalex.org/W2484552604","https://openalex.org/W3084281104","https://openalex.org/W2921734209","https://openalex.org/W4402630635","https://openalex.org/W4213163693"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}