{"id":"https://openalex.org/W2002198770","doi":"https://doi.org/10.1023/a:1025317516396","title":"Fas Ligand-Mediated Apoptosis in Degenerative Disorders of the Brain","display_name":"Fas Ligand-Mediated Apoptosis in Degenerative Disorders of the Brain","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2002198770","doi":"https://doi.org/10.1023/a:1025317516396","mag":"2002198770","pmid":"https://pubmed.ncbi.nlm.nih.gov/14601644"},"language":"en","primary_location":{"id":"doi:10.1023/a:1025317516396","doi":"https://doi.org/10.1023/a:1025317516396","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1025317516396","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079722104","display_name":"Douglas W. Ethell","orcid":"https://orcid.org/0000-0002-9237-0265","observed_orcids":["https://orcid.org/0000-0002-9237-0265"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas W. Ethell","raw_affiliation_strings":["Division of Biomedical Sciences, University of California-Riverside, 900 University Avenue, Riverside, California 92521-0121, USA. doug.ethell@ucr.edu","Division of Biomedical Sciences, University of California \u2013 Riverside, Riverside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California-Riverside, 900 University Avenue, Riverside, California 92521-0121, USA. doug.ethell@ucr.edu","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Division of Biomedical Sciences, University of California \u2013 Riverside, Riverside","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048790227","display_name":"Lillian A. Buhler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillian A. Buhler","raw_affiliation_strings":["Graduate Program in Biochemistry and Molecular Biology, University of California \u2013 Riverside, Riverside, California","Graduate program in Biochemistry and Molecular Biology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biochemistry and Molecular Biology, University of California \u2013 Riverside, Riverside, California","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Graduate program in Biochemistry and Molecular Biology, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079722104"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.35,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.31448023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"5","first_page":"363","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8740000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/immune-cell-apoptosis","display_name":"immune cell apoptosis","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.9016400575637817},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7460945248603821},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6811738014221191},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6537890434265137},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6279534101486206},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6100365519523621},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.516226053237915},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5121779441833496},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4963403344154358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4452981948852539},{"id":"https://openalex.org/C2909079248","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative Disorder","level":3,"score":0.4230741262435913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39282509684562683},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3500444293022156},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22531771659851074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07595688104629517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.066395103931427}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1023/a:1025317516396","doi":"https://doi.org/10.1023/a:1025317516396","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1025317516396","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:14601644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14601644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Journal Article"},{"id":"pmid:15031631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15031631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G146471750","display_name":null,"funder_award_id":"AG21652","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8085448043","display_name":"FasL Signaling in Beta-Amyloid Neurotoxicity","funder_award_id":"1r03ag021652-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1488841360","https://openalex.org/W1528113046","https://openalex.org/W1598872310","https://openalex.org/W1621971853","https://openalex.org/W1634780921","https://openalex.org/W1642763135","https://openalex.org/W1806409302","https://openalex.org/W1862355269","https://openalex.org/W1877363685","https://openalex.org/W1965275873","https://openalex.org/W1967894078","https://openalex.org/W1972183604","https://openalex.org/W1973231428","https://openalex.org/W1974182280","https://openalex.org/W1976571982","https://openalex.org/W1977200209","https://openalex.org/W1978018492","https://openalex.org/W1979016396","https://openalex.org/W1980945609","https://openalex.org/W1982476760","https://openalex.org/W1983731041","https://openalex.org/W1987265109","https://openalex.org/W1987319516","https://openalex.org/W1991212304","https://openalex.org/W1995644527","https://openalex.org/W1996511362","https://openalex.org/W1996980134","https://openalex.org/W1997939119","https://openalex.org/W1997951257","https://openalex.org/W2002273797","https://openalex.org/W2002733542","https://openalex.org/W2004645606","https://openalex.org/W2008219426","https://openalex.org/W2008354106","https://openalex.org/W2011630305","https://openalex.org/W2012173029","https://openalex.org/W2013377378","https://openalex.org/W2013533632","https://openalex.org/W2014886449","https://openalex.org/W2020951538","https://openalex.org/W2024494606","https://openalex.org/W2025554920","https://openalex.org/W2036392611","https://openalex.org/W2038786895","https://openalex.org/W2042241222","https://openalex.org/W2043639971","https://openalex.org/W2047658053","https://openalex.org/W2050702634","https://openalex.org/W2059473240","https://openalex.org/W2060319440","https://openalex.org/W2060820237","https://openalex.org/W2063308963","https://openalex.org/W2065884286","https://openalex.org/W2068477037","https://openalex.org/W2069263824","https://openalex.org/W2070618871","https://openalex.org/W2072103796","https://openalex.org/W2077153831","https://openalex.org/W2077975299","https://openalex.org/W2078989453","https://openalex.org/W2083485745","https://openalex.org/W2086313080","https://openalex.org/W2087374220","https://openalex.org/W2088590507","https://openalex.org/W2112296339","https://openalex.org/W2115937412","https://openalex.org/W2116784956","https://openalex.org/W2119304779","https://openalex.org/W2119683782","https://openalex.org/W2129971278","https://openalex.org/W2130937867","https://openalex.org/W2135841642","https://openalex.org/W2141487162","https://openalex.org/W2147122201","https://openalex.org/W2149152049","https://openalex.org/W2149954869","https://openalex.org/W2152742643","https://openalex.org/W2158660192","https://openalex.org/W2168945225","https://openalex.org/W4285719527","https://openalex.org/W4313333657","https://openalex.org/W4313341495","https://openalex.org/W4313635391"],"related_works":["https://openalex.org/W2082042799","https://openalex.org/W2117285167","https://openalex.org/W2004827012","https://openalex.org/W2328451887","https://openalex.org/W124123819","https://openalex.org/W2188887289","https://openalex.org/W2089046755","https://openalex.org/W1521936885","https://openalex.org/W1532974485","https://openalex.org/W2016667430"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}