{"id":"https://openalex.org/W2002197941","doi":"https://doi.org/10.1182/blood-2004-10-4035","title":"NK-dependent DC maturation is mediated by TNF\u03b1 and IFN\u03b3 released upon engagement of the NKp30 triggering receptor","display_name":"NK-dependent DC maturation is mediated by TNF\u03b1 and IFN\u03b3 released upon engagement of the NKp30 triggering receptor","publication_year":2005,"publication_date":"2005-03-23","ids":{"openalex":"https://openalex.org/W2002197941","doi":"https://doi.org/10.1182/blood-2004-10-4035","mag":"2002197941","pmid":"https://pubmed.ncbi.nlm.nih.gov/15784725"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2004-10-4035","doi":"https://doi.org/10.1182/blood-2004-10-4035","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-10-4035","pdf_url":"https://ashpublications.org/blood/article-pdf/106/2/566/1712017/zh801405000566.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2002197941"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/106/2/566/1712017/zh801405000566.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068187248","display_name":"Massimo Vitale","orcid":"https://orcid.org/0000-0001-5372-7885","observed_orcids":["https://orcid.org/0000-0001-5372-7885"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Vitale","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006521329","display_name":"Mariella Della Chiesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariella Della Chiesa","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029764194","display_name":"Simona Carlomagno","orcid":"https://orcid.org/0000-0001-8522-1176","observed_orcids":["https://orcid.org/0000-0001-8522-1176"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Carlomagno","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035849763","display_name":"Daniela Pende","orcid":"https://orcid.org/0000-0003-1565-451X","observed_orcids":["https://orcid.org/0000-0003-1565-451X"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Pende","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070232314","display_name":"Maurizio Aric\u00f2","orcid":"https://orcid.org/0000-0002-1908-6671","observed_orcids":["https://orcid.org/0000-0002-1908-6671"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Arico\u0300","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020843731","display_name":"Lorenzo Moretta","orcid":"https://orcid.org/0000-0003-4658-1747","observed_orcids":["https://orcid.org/0000-0003-4658-1747"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Moretta","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113465265","display_name":"Alessandro Moretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Moretta","raw_affiliation_strings":["From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","Istituto Giannina Gaslini, Genova-Quarto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy; Dipartimento di Medicina Sperimentale (DIMES), Universita\u0300 di Genova, Genova, Italy; Onco Ematologia Pediatrica, Ospedale dei Bambini G. Di Cristina, Palermo, Italy; Istituto Giannina Gaslini, Genova-Quarto, Italy; and Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"From the Istituto Scientifico per la Ricerca sul Cancro (IST), Genova, Italy","institution_ids":[]},{"raw_affiliation_string":"Istituto Giannina Gaslini, Genova-Quarto, Italy","institution_ids":["https://openalex.org/I2801463291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":11.0367,"has_fulltext":true,"cited_by_count":435,"citation_normalized_percentile":{"value":0.99067275,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"106","issue":"2","first_page":"566","last_page":"571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nkp30","display_name":"NKp30","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nkg2a","display_name":"NKG2A","score":0.9390000104904175},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.6594130992889404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5977197885513306},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.537025511264801},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5172696709632874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49845337867736816},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47274670004844666},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4550626277923584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4128768742084503},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3098386526107788},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.26941174268722534},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11987510323524475},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.09819167852401733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015616","descriptor_name":"Histiocytosis, Non-Langerhans-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015616","descriptor_name":"Histiocytosis, Non-Langerhans-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055628","descriptor_name":"Natural Cytotoxicity Triggering Receptor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2004-10-4035","doi":"https://doi.org/10.1182/blood-2004-10-4035","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-10-4035","pdf_url":"https://ashpublications.org/blood/article-pdf/106/2/566/1712017/zh801405000566.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:15784725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15784725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/265382","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/265382","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zenodo.org:193466","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/193466","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/blood-2004-10-4035","doi":"https://doi.org/10.1182/blood-2004-10-4035","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2004-10-4035","pdf_url":"https://ashpublications.org/blood/article-pdf/106/2/566/1712017/zh801405000566.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309746","display_name":"Compagnia di San Paolo","ror":"https://ror.org/00d1b1c41"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002197941.pdf","grobid_xml":"https://content.openalex.org/works/W2002197941.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1556867369","https://openalex.org/W1571520647","https://openalex.org/W1655860314","https://openalex.org/W1887194818","https://openalex.org/W1943350189","https://openalex.org/W1959947589","https://openalex.org/W1969814796","https://openalex.org/W1970753581","https://openalex.org/W1977797737","https://openalex.org/W2003220523","https://openalex.org/W2022273444","https://openalex.org/W2023144585","https://openalex.org/W2033081825","https://openalex.org/W2042113030","https://openalex.org/W2059500374","https://openalex.org/W2081670280","https://openalex.org/W2095326716","https://openalex.org/W2099019634","https://openalex.org/W2104685421","https://openalex.org/W2109924462","https://openalex.org/W2113403004","https://openalex.org/W2129629785","https://openalex.org/W2130649175","https://openalex.org/W2138453647","https://openalex.org/W2154518608","https://openalex.org/W2157807543","https://openalex.org/W2162620875","https://openalex.org/W2165920713","https://openalex.org/W2168459600","https://openalex.org/W2170419443","https://openalex.org/W2172005924","https://openalex.org/W2591655035"],"related_works":["https://openalex.org/W2165920713","https://openalex.org/W2113403004","https://openalex.org/W2047512025","https://openalex.org/W69278965","https://openalex.org/W2364114353","https://openalex.org/W2162620875","https://openalex.org/W38187747","https://openalex.org/W2517626017","https://openalex.org/W2314374646","https://openalex.org/W8855417"],"abstract_inverted_index":{"Natural":[0],"killer":[1,174],"(NK)":[2],"cells":[3,62,94,133,171,186],"were":[4],"recently":[5],"shown":[6],"to":[7,163,169],"play":[8],"a":[9,39],"relevant":[10],"role":[11],"in":[12,90,106,203],"the":[13,50,53,57,76,155,161,173,181,188,191,204],"process":[14],"of":[15,44,52,79,112,122,183,190,206],"dendritic":[16],"cell":[17],"(DC)":[18],"maturation.":[19,110],"This":[20,149],"function":[21,51,151],"is":[22,47,66,82,152],"exerted":[23],"either":[24],"by":[25,59,145,154],"direct":[26],"DC":[27,64,80,109,138,201,208],"stimulation":[28],"or":[29],"through":[30],"killing":[31,43],"those":[32],"DCs":[33,46,123],"that":[34,74],"did":[35],"not":[36],"properly":[37],"acquire":[38],"mature":[40],"phenotype.":[41,179],"While":[42],"immature":[45],"dependent":[48,83],"on":[49,84],"NKp30":[54,91,113,136,150,197],"triggering":[55],"receptor,":[56],"mechanism":[58],"which":[60],"NK":[61,93,126,132,158,170,185],"induce":[63,199],"maturation":[65,81,121,165,202],"still":[67],"unclear.":[68],"In":[69,128],"this":[70,141],"study,":[71],"we":[72],"show":[73],"also":[75],"NK-mediated":[77,207],"induction":[78],"NKp30.":[85],"Upon":[86],"NK/DC":[87],"interaction,":[88],"resulting":[89],"engagement,":[92],"produced":[95],"tumor":[96],"necrosis":[97],"factor":[98],"alpha":[99],"(TNFalpha)":[100],"(and":[101],"interferon":[102],"gamma":[103],"[IFNgamma])":[104],"that,":[105],"turn,":[107],"promoted":[108],"Masking":[111],"with":[114,125],"specific":[115],"monoclonal":[116],"antibodies":[117,147],"(mAbs)":[118],"strongly":[119],"reduced":[120],"cocultured":[124],"cells.":[127],"addition,":[129],"supernatant":[130],"from":[131],"stimulated":[134],"via":[135],"induced":[137],"maturation,":[139],"and":[140],"effect":[142],"was":[143,166],"neutralized":[144],"anti-TNFalpha":[146],"(Abs).":[148],"controlled":[153],"HLA-specific":[156],"inhibitory":[157],"receptors.":[159],"Accordingly,":[160],"ability":[162],"promote":[164],"essentially":[167],"confined":[168],"expressing":[172],"immunoglobulin-like":[175],"receptor-negative":[176],"(KIR-)":[177],"NKG2A(dull)":[178],"Finally,":[180],"analysis":[182],"perforin-deficient":[184],"allowed":[187],"dissection":[189],"2":[192],"NKp30-mediated":[193],"NK-cell":[194],"functions,":[195],"since":[196],"could":[198],"cytokine-dependent":[200],"absence":[205],"killing.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}