{"id":"https://openalex.org/W2002192325","doi":"https://doi.org/10.1055/s-2006-959752","title":"Inhibition of Autochthonous Tumor by Ethanol Insoluble Fraction fromPanax ginsengas an Immunomodulator","display_name":"Inhibition of Autochthonous Tumor by Ethanol Insoluble Fraction fromPanax ginsengas an Immunomodulator","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2002192325","doi":"https://doi.org/10.1055/s-2006-959752","mag":"2002192325","pmid":"https://pubmed.ncbi.nlm.nih.gov/8302951"},"language":"en","primary_location":{"id":"doi:10.1055/s-2006-959752","doi":"https://doi.org/10.1055/s-2006-959752","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-959752","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111622052","display_name":"Yeon\u2010Sook Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon Yun","raw_affiliation_strings":["Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, Seoul","Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, Seoul","institution_ids":["https://openalex.org/I155671955"]},{"raw_affiliation_string":"Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea","institution_ids":["https://openalex.org/I155671955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101605567","display_name":"Yun Jung Lee","orcid":"https://orcid.org/0000-0002-9347-8606","observed_orcids":["https://orcid.org/0000-0002-9347-8606"]},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Lee","raw_affiliation_strings":["Laboratory of Cancer Pathology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Pathology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea","institution_ids":["https://openalex.org/I155671955"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sung Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Jo","raw_affiliation_strings":["Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea","institution_ids":["https://openalex.org/I155671955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108749610","display_name":"In Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Jung","raw_affiliation_strings":["Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Korea Cancer Center Hospital, KAERI, 215-4 Gongneung-Dong, Nowon-Ku, Seoul 139-240, Korea","institution_ids":["https://openalex.org/I155671955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155671955"],"apc_list":null,"apc_paid":null,"fwci":0.2891,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.41868798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"59","issue":"06","first_page":"521","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panax-ginseng","display_name":"Panax ginseng","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/splenocyte-proliferation","display_name":"splenocyte proliferation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autochthonous-tumors","display_name":"autochthonous tumors","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.9402332901954651},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7745742201805115},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.7231542468070984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5924365520477295},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5203173160552979},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.4955936670303345},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4917657673358917},{"id":"https://openalex.org/C2778148229","wikidata":"https://www.wikidata.org/wiki/Q2737217","display_name":"American ginseng","level":4,"score":0.4865528643131256},{"id":"https://openalex.org/C2778770856","wikidata":"https://www.wikidata.org/wiki/Q193335","display_name":"Araliaceae","level":4,"score":0.4220421314239502},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4107622802257538},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3639630079269409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35276228189468384},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.3420105576515198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26419055461883545},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005894","descriptor_name":"Panax","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-959752","doi":"https://doi.org/10.1055/s-2006-959752","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-959752","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:8302951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8302951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W290577262","https://openalex.org/W2160247562","https://openalex.org/W87555658","https://openalex.org/W1987753152","https://openalex.org/W2203914816","https://openalex.org/W2071524877","https://openalex.org/W2408963997","https://openalex.org/W2002586761","https://openalex.org/W2013800351","https://openalex.org/W1975886009"],"abstract_inverted_index":{"The":[0,23,122],"water":[1,105,152],"extract":[2],"of":[3,26,56,71,81,84,94,109,144,167],"Panax":[4],"ginseng":[5,27,59,168],"was":[6,18,60,87,101],"fractionated":[7],"by":[8,58],"its":[9],"solubility":[10],"in":[11,37,103,150],"ethanol":[12],"and":[13,32,48,99],"then":[14],"the":[15,63,69,74,137,154,164],"ethanol-insoluble":[16,24,165],"fraction":[17,25,166],"tested":[19],"for":[20,117],"immunomodulatory":[21],"activity.":[22],"(Fr.":[28],"3)":[29],"proliferated":[30],"splenocytes":[31,57],"generated":[33],"activated":[34,40],"killer":[35,41],"cells":[36,42,52],"vitro.":[38],"These":[39,160],"killed":[43],"both":[44],"NK":[45],"cell":[46],"sensitive":[47],"insensitive":[49],"tumor":[50,130],"target":[51],"without":[53],"MHC-restriction.":[54],"Activation":[55],"mediated":[61],"through":[62],"endogenously":[64],"produced":[65],"IL-2.":[66],"To":[67],"investigate":[68],"effects":[70,171],"Fr.3":[72,100],"on":[73],"autochthonous":[75],"neoplasm,":[76],"a":[77,107,142],"single":[78],"subcutaneous":[79],"injection":[80],"0.5":[82,115],"mg":[83],"benzo[a]pyrene":[85],"(BP)":[86],"given":[88],"within":[89],"24":[90],"hours":[91],"after":[92,120,157],"birth":[93],"male":[95],"N:":[96],"GP(S)":[97],"mice,":[98],"administered":[102],"drinking":[104,151],"at":[106,141,153],"concentration":[108,143],"2":[110,145],"mg/ml,":[111,113],"1":[112,148],"or":[114,147],"mg/ml":[116,146,149],"6":[118],"weeks":[119],"weaning.":[121],"treatment":[123],"with":[124,136],"Fr.":[125],"3":[126],"significantly":[127],"inhibited":[128],"lung":[129],"incidence":[131],"(P":[132],"<":[133],"0.05)":[134],"compared":[135],"BP":[138,158],"alone":[139],"group":[140],"9th":[155],"week":[156],"treatment.":[159],"results":[161],"suggest":[162],"that":[163],"shows":[169],"antitumor":[170],"as":[172],"an":[173],"immunomodulator.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}