{"id":"https://openalex.org/W2002191849","doi":"https://doi.org/10.4161/cc.8.10.8415","title":"Targeting transcription factor NF\u03baB: comparative analysis of proteasome and IKK inhibitors","display_name":"Targeting transcription factor NF\u03baB: comparative analysis of proteasome and IKK inhibitors","publication_year":2009,"publication_date":"2009-05-15","ids":{"openalex":"https://openalex.org/W2002191849","doi":"https://doi.org/10.4161/cc.8.10.8415","mag":"2002191849","pmid":"https://pubmed.ncbi.nlm.nih.gov/19372735"},"language":"en","primary_location":{"id":"doi:10.4161/cc.8.10.8415","doi":"https://doi.org/10.4161/cc.8.10.8415","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.8.10.8415","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.8.10.8415?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.8.10.8415?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110113596","display_name":"Alexander V. Gasparian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113396","display_name":"Cleveland BioLabs (United States)","ror":"https://ror.org/02bxsr265","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander V. Gasparian","raw_affiliation_strings":["Cleveland Biolabs, Inc., Buffalo, NY 14203, USA. agasparian@cbiolabs.com","Cleveland Biolabs, Inc., Buffalo, NY 14203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Biolabs, Inc., Buffalo, NY 14203, USA. agasparian@cbiolabs.com","institution_ids":["https://openalex.org/I4210113396"]},{"raw_affiliation_string":"Cleveland Biolabs, Inc., Buffalo, NY 14203, USA","institution_ids":["https://openalex.org/I4210113396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014754069","display_name":"Olga A. Guryanova","orcid":"https://orcid.org/0000-0002-6514-8466","observed_orcids":["https://orcid.org/0000-0002-6514-8466","https://orcid.org/0000-0003-4974-3166"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga A. Guryanova","raw_affiliation_strings":["Department of Molecular Genetics ; Cleveland Clinic ; Cleveland , OH USA;","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics ; Cleveland Clinic ; Cleveland , OH USA;","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042497703","display_name":"Dmitry V. Chebotaev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry V. Chebotaev","raw_affiliation_strings":["Department of Dermatology ; Northwestern University ; Chicago , IL USA;","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology ; Northwestern University ; Chicago , IL USA;","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander A. Shishkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Shishkin","raw_affiliation_strings":["Department of Biology ; Tufts University ; Medford , MA USA","Tufts University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology ; Tufts University ; Medford , MA USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Tufts University","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090810022","display_name":"Alexander Yu. Yemelyanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Y. Yemelyanov","raw_affiliation_strings":["Department of Dermatology ; Northwestern University ; Chicago , IL USA;","Medicine, Pulmonary Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology ; Northwestern University ; Chicago , IL USA;","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Medicine, Pulmonary Division","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027599075","display_name":"Irina V. Budunova","orcid":"https://orcid.org/0000-0001-5880-6822","observed_orcids":["https://orcid.org/0000-0001-5880-6822"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina V. Budunova","raw_affiliation_strings":["Department of Dermatology ; Northwestern University ; Chicago , IL USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology ; Northwestern University ; Chicago , IL USA;","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110113596"],"corresponding_institution_ids":["https://openalex.org/I4210113396"],"apc_list":null,"apc_paid":null,"fwci":2.1219,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87687468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"10","first_page":"1559","last_page":"1566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8119999766349792},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ikappab-kinase-inhibitors","display_name":"I\u03baB kinase inhibitors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ikappab-degradation","display_name":"I\u03baB degradation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6909999847412109},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.6869999766349792},{"id":"https://openalex.org/keywords/p50-homodimer","display_name":"p50 homodimer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.7009999752044678},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7300000190734863},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mg132","display_name":"MG132","score":0.7390000224113464},{"id":"https://openalex.org/keywords/lactacystin","display_name":"lactacystin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/epoxomicin","display_name":"epoxomicin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bay-11-7082","display_name":"BAY 11-7082","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8729609251022339},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7625735998153687},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6690466403961182},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.6407201290130615},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.5551931262016296},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.49549686908721924},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42893850803375244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4234223961830139},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42102497816085815},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.414340078830719},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36976391077041626},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.270803838968277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2077871561050415},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.8.10.8415","doi":"https://doi.org/10.4161/cc.8.10.8415","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.8.10.8415","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.8.10.8415?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:19372735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19372735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.4161/cc.8.10.8415","doi":"https://doi.org/10.4161/cc.8.10.8415","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.8.10.8415","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.8.10.8415?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002191849.pdf","grobid_xml":"https://content.openalex.org/works/W2002191849.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042709514","https://openalex.org/W1976877690","https://openalex.org/W2015883486","https://openalex.org/W2006690126","https://openalex.org/W2023230437","https://openalex.org/W61707286","https://openalex.org/W2073683774","https://openalex.org/W2074272716","https://openalex.org/W2201585521","https://openalex.org/W2086123367"],"abstract_inverted_index":{"Nuclear":[0],"factorkappaB":[1],"(NFkappaB)":[2],"plays":[3,162],"a":[4,163],"critical":[5],"role":[6,165],"in":[7,29,137,166,208],"cancer":[8,21],"development":[9],"and":[10,23,34,58,79,81,86,97,124],"progression.":[11],"Thus,":[12],"the":[13,44,61,71,133,160,191,220],"NFkappaB":[14,30,50,90,116,127,153,229],"signaling":[15],"pathway":[16],"provides":[17],"important":[18,178],"targets":[19],"for":[20,179],"chemoprevention":[22],"anticancer":[24],"chemotherapy.":[25],"The":[26],"central":[27],"steps":[28],"activation":[31],"are":[32],"phosphorylation":[33],"proteasome-dependent":[35],"degradation":[36,62],"of":[37,54,63,73,115,152,169,185,194,225,238],"its":[38],"inhibitory":[39],"proteins":[40],"termed":[41],"IkappaBs.":[42],"Consequently,":[43],"major":[45],"pharmacological":[46],"approaches":[47],"to":[48,88,98,104,139,197,212,216],"target":[49],"include":[51],"(1)":[52],"repression":[53],"IkappaB":[55],"kinases":[56],"(IKKs)":[57],"(2)":[59],"blocking":[60],"IkappaBs":[64],"by":[65,93],"proteasome":[66,75,121,144,161,195,202,239],"inhibitors.":[67,117,135],"We":[68,118,231],"quantitatively":[69],"compared":[70,215],"efficacy":[72],"various":[74],"inhibitors":[76,83,122,145,196,203,218,240],"(MG132,":[77],"lactacystin":[78],"epoxomicin)":[80],"IKK":[82,134,140,174,217],"(BAY":[84],"11-7082":[85],"PS1145)":[87],"block":[89],"activity":[91,175],"induced":[92],"TNFalpha":[94],"or":[95],"TPA":[96],"sensitize":[99],"LNCaP":[100,210],"prostate":[101],"carcinoma":[102],"cells":[103,211],"apoptosis.":[105],"Our":[106],"studies":[107],"revealed":[108],"significant":[109],"differences":[110],"between":[111],"these":[112],"two":[113],"classes":[114],"found":[119],"that":[120,159,233],"epoxomicin":[123],"MG132":[125],"attenuated":[126,228],"induction":[128],"much":[129,205],"more":[130,206],"effectively":[131],"than":[132],"Furthermore,":[136],"contrast":[138],"inhibitors,":[141],"all":[142],"studied":[143],"specifically":[146],"blocked":[147],"TPA-induced":[148,167],"generation":[149],"de":[150],"novo":[151],"p50":[154,171],"homodimers--(p50/p50).":[155],"These":[156],"results":[157],"suggest":[158],"dominant":[164],"formation":[168],"functional":[170],"homodimers,":[172],"while":[173],"is":[176,241],"less":[177],"this":[180,234],"process.":[181],"Interestingly,":[182],"profound":[183],"attenuation":[184],"p50/p50":[186],"DNA-binding":[187],"does":[188],"not":[189],"reduce":[190],"high":[192],"potency":[193],"suppress":[198],"NFkappaB-dependent":[199],"transcription.":[200],"Finally,":[201],"were":[204],"effective":[207],"sensitizing":[209],"TNFalpha-induced":[213],"apoptosis":[214],"at":[219],"concentrations":[221],"when":[222],"both":[223],"types":[224],"agents":[226],"similarly":[227],"activity.":[230],"conclude":[232],"remarkable":[235],"pro-apoptotic":[236],"potential":[237],"partially":[242],"mediated":[243],"through":[244],"NFkappaB-independent":[245],"mechanism.":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
