{"id":"https://openalex.org/W2002187188","doi":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","title":"Simultaneous signalling through c\u2010mpl, c\u2010kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3\u2010K, PKC and MAPK pathways","display_name":"Simultaneous signalling through c\u2010mpl, c\u2010kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3\u2010K, PKC and MAPK pathways","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2002187188","doi":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","mag":"2002187188","pmid":"https://pubmed.ncbi.nlm.nih.gov/11722431"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.2001.03068.x","doi":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2002187188"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046562223","display_name":"Hitoshi Minamiguchi","orcid":"https://orcid.org/0000-0003-4450-0106","observed_orcids":["https://orcid.org/0000-0003-4450-0106"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Minamiguchi","raw_affiliation_strings":["Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031325837","display_name":"Takafumi Kimura","orcid":"https://orcid.org/0000-0002-8718-2024","observed_orcids":["https://orcid.org/0000-0002-8718-2024"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Kimura","raw_affiliation_strings":["Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,","the Second Department of Internal Medicine, Shiga University of Medical Science, Shiga,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"the Second Department of Internal Medicine, Shiga University of Medical Science, Shiga,","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104025780","display_name":"Yoji Urata","orcid":"https://orcid.org/0009-0005-1485-1791","observed_orcids":["https://orcid.org/0009-0005-1485-1791"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Urata","raw_affiliation_strings":["First Department of Pathology, Kyoto Prefectural University of Medicine, Kyoto, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Kyoto Prefectural University of Medicine, Kyoto, and","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045269393","display_name":"Hiroshi Miyazaki","orcid":"https://orcid.org/0000-0002-6635-1618","observed_orcids":["https://orcid.org/0000-0002-6635-1618"]},"institutions":[{"id":"https://openalex.org/I2802592688","display_name":"Kirin (Japan)","ror":"https://ror.org/0586k5242","country_code":"JP","type":"company","lineage":["https://openalex.org/I2802592688"]},{"id":"https://openalex.org/I4405274001","display_name":"Kirin Brewery Company, Limited (Japan)","ror":"https://ror.org/00vm6vn72","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Miyazaki","raw_affiliation_strings":["Kirin Brewery Co. Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kirin Brewery Co. Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405274001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109271207","display_name":"Tadao Bamba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadao Bamba","raw_affiliation_strings":["the Second Department of Internal Medicine, Shiga University of Medical Science, Shiga,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Second Department of Internal Medicine, Shiga University of Medical Science, Shiga,","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111518885","display_name":"Tatsuo Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Abe","raw_affiliation_strings":["Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103188708","display_name":"Yoshiaki Sonoda","orcid":"https://orcid.org/0000-0002-2832-1899","observed_orcids":["https://orcid.org/0000-0002-2832-1899"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiaki Sonoda","raw_affiliation_strings":["Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto,","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103188708"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.3968,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.80900418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"115","issue":"1","first_page":"175","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/megakaryocyte-progenitors","display_name":"megakaryocyte progenitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.7889999747276306},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.7080000042915344},{"id":"https://openalex.org/keywords/c-mpl","display_name":"c-Mpl","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/endomitosis","display_name":"endomitosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/megakaryocyte-ploidy","display_name":"megakaryocyte ploidy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/proplatelet-formation","display_name":"proplatelet formation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.7128080725669861},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.6570367813110352},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6321756839752197},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5769670605659485},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5455808043479919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5260757803916931},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.49304530024528503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47844886779785156},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4593662619590759},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.4330926537513733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40621981024742126},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40532806515693665},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3893055021762848},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3696094751358032},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30817317962646484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16487792134284973},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14135131239891052},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.08626037836074829}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053628","descriptor_name":"Receptors, Thrombopoietin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.2001.03068.x","doi":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2001.03068.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:11722431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11722431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W28083597","https://openalex.org/W154306038","https://openalex.org/W168208124","https://openalex.org/W181632829","https://openalex.org/W192651359","https://openalex.org/W266038086","https://openalex.org/W280141668","https://openalex.org/W299764968","https://openalex.org/W1500588205","https://openalex.org/W1532087698","https://openalex.org/W1539398892","https://openalex.org/W1897742525","https://openalex.org/W1903887594","https://openalex.org/W1987686674","https://openalex.org/W2002677295","https://openalex.org/W2012757306","https://openalex.org/W2034297565","https://openalex.org/W2046188084","https://openalex.org/W2059439210","https://openalex.org/W2078469968","https://openalex.org/W2094920967","https://openalex.org/W2106173703","https://openalex.org/W2118020691","https://openalex.org/W2146416811","https://openalex.org/W2230765375","https://openalex.org/W2230842386","https://openalex.org/W2258378031","https://openalex.org/W2258879728","https://openalex.org/W2276322160","https://openalex.org/W2281127542","https://openalex.org/W2299861015","https://openalex.org/W2397145236","https://openalex.org/W2403058886","https://openalex.org/W2415380635","https://openalex.org/W2433193416","https://openalex.org/W2464553351"],"related_works":["https://openalex.org/W2023648526","https://openalex.org/W2168784041","https://openalex.org/W1510842546","https://openalex.org/W2442466414","https://openalex.org/W1990432578","https://openalex.org/W2006840197","https://openalex.org/W28083597","https://openalex.org/W2299861015","https://openalex.org/W280141668"],"abstract_inverted_index":{"We":[0],"assessed":[1],"the":[2,9,20,74,96,104,146,173,178,199,208,220,226,244],"effect":[3,68,174],"of":[4,13,24,46,76,80,98,106,119,153,175,180,184,202,210,228,234,250,257],"signalling":[5],"through":[6,237],"CXCR4":[7,241],"on":[8,69,111,177],"proliferation":[10,247],"and":[11,83,116,121,164,240,248,252],"differentiation":[12,249],"human":[14,258],"megakaryocytic":[15],"progenitor":[16],"cells":[17,36],"(CFU-Meg)":[18],"in":[19,73,245],"presence":[21,75,209],"or":[22,54,125,196],"absence":[23],"stem":[25],"cell":[26],"factor":[27],"(SCF)":[28],"and/or":[29],"thrombopoietin":[30],"(TPO),":[31],"using":[32],"peripheral":[33],"blood-derived":[34],"CD34(+)IL-6R(-)":[35],"as":[37,87,91,205],"a":[38,43,66,133,255],"target.":[39],"TPO":[40,84,92,158,161,165],"alone":[41,56],"induced":[42,85],"significant":[44],"number":[45],"CFU-Meg":[47,60,70,89,112,140],"colonies.":[48],"Although":[49],"stromal":[50],"cell-derived":[51],"factor-1":[52],"(SDF-1)":[53],"SCF":[55,82,167],"did":[57,137],"not":[58,138],"support":[59],"colony":[61,71,113,141],"formation,":[62],"these":[63],"factors":[64],"had":[65],"synergistic":[67,100,129],"formation":[72,213],"TPO.":[77,188],"The":[78],"combination":[79],"SDF-1,":[81,163,169],"twice":[86],"many":[88],"colonies":[90],"alone.":[93],"To":[94],"investigate":[95],"mechanism":[97],"this":[99,128],"action,":[101],"we":[102],"examined":[103],"effects":[105],"various":[107],"protein":[108],"kinase":[109],"inhibitors":[110],"formation.":[114,142],"LY294002":[115],"GF109203X":[117],"(inhibitors":[118],"PI3-K":[120],"PKC":[122],"respectively)":[123],"completely":[124],"partially":[126],"inhibited":[127],"action.":[130],"In":[131,207,230],"contrast,":[132],"MEK":[134],"inhibitor":[135],"(PD98059)":[136],"inhibit":[139,225],"It":[143],"significantly":[144,216],"increased":[145],"higher":[147,181],"ploidy":[148,182],"classes":[149,183],"(16N":[150],"to":[151],"64N)":[152],"megakaryocytes":[154,185],"supported":[155,186],"by":[156,187],"TPO,":[157],"+":[159,162,166,168],"SCF,":[160],"whereas":[170],"it":[171],"abolished":[172],"SDF-1":[176,253],"increase":[179],"These":[189],"results":[190],"suggest":[191],"that":[192,219],"MAPK":[193,221],"may":[194,223],"negatively":[195],"positively":[197],"regulate":[198],"nuclear":[200],"maturation":[201],"megakaryocytes,":[203],"known":[204],"endomitosis.":[206],"PD98059,":[211],"proplatelet":[212],"(PPF)":[214],"was":[215],"augmented,":[217],"suggesting":[218],"pathway":[222],"also":[224],"initiation":[227],"PPF.":[229],"conclusion,":[231],"simultaneous":[232],"activation":[233],"three":[235],"signals":[236],"c-mpl,":[238],"c-kit":[239],"can":[242],"induce":[243],"vitro":[246],"CFU-Meg,":[251],"is":[254],"potentiator":[256],"megakaryocytopoiesis.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
