{"id":"https://openalex.org/W2002186586","doi":"https://doi.org/10.1038/380630a0","title":"Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene","display_name":"Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene","publication_year":1996,"publication_date":"1996-04-18","ids":{"openalex":"https://openalex.org/W2002186586","doi":"https://doi.org/10.1038/380630a0","mag":"2002186586","pmid":"https://pubmed.ncbi.nlm.nih.gov/8602264"},"language":"en","primary_location":{"id":"doi:10.1038/380630a0","doi":"https://doi.org/10.1038/380630a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/380630a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079272025","display_name":"Kazuya Shimoda","orcid":"https://orcid.org/0000-0002-2555-8188","observed_orcids":["https://orcid.org/0000-0002-2555-8188"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuya Shimoda","raw_affiliation_strings":["Department of Biochemistry, St Jude Children's Research Hospital, Memphis, Tennessee 38105 USA","Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, St Jude Children's Research Hospital, Memphis, Tennessee 38105 USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001269097","display_name":"Jan van Deursent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan van Deursent","raw_affiliation_strings":["Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052397317","display_name":"Mark Y. Sangster","orcid":"https://orcid.org/0000-0002-1599-5894","observed_orcids":["https://orcid.org/0000-0002-1599-5894"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Y. Sangster","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057898118","display_name":"Sally R. Sarawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally R. Sarawar","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard T. Carson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard T. Carson","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053051899","display_name":"Ralph A. Tripp","orcid":"https://orcid.org/0000-0002-2924-9956","observed_orcids":["https://orcid.org/0000-0002-2924-9956"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Tripp","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009176977","display_name":"Charles C. Chu","orcid":"https://orcid.org/0000-0002-9353-0806","observed_orcids":["https://orcid.org/0000-0002-9353-0806"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Chu","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA","Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085327021","display_name":"Frederick W. Quelle","orcid":"https://orcid.org/0000-0002-1184-6170","observed_orcids":["https://orcid.org/0000-0002-1184-6170"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick W. Quelle","raw_affiliation_strings":["Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080390178","display_name":"Tetsuya Nosaka","orcid":"https://orcid.org/0000-0002-0037-7049","observed_orcids":["https://orcid.org/0000-0002-0037-7049"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuya Nosaka","raw_affiliation_strings":["Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001000053","display_name":"Dario A.A. Vignali","orcid":"https://orcid.org/0000-0002-2771-5992","observed_orcids":["https://orcid.org/0000-0002-2771-5992"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dario A. A. Vignali","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074692390","display_name":"Peter C. Doherty","orcid":"https://orcid.org/0000-0002-5028-3489","observed_orcids":["https://orcid.org/0000-0002-5028-3489","https://orcid.org/0000-0001-6863-0533"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. C. Doherty","raw_affiliation_strings":["Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026036897","display_name":"Gerard C. Grosveld","orcid":"https://orcid.org/0000-0002-6583-1265","observed_orcids":["https://orcid.org/0000-0002-6583-1265"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Grosveld","raw_affiliation_strings":["Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Genetics, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110910083","display_name":"W E Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. E. Paul","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA","Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114003398","display_name":"James N. Ihle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. N. Ihle","raw_affiliation_strings":["Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Departments of Biochemistry, St Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":45.3727,"has_fulltext":false,"cited_by_count":1279,"citation_normalized_percentile":{"value":0.9994652,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"380","issue":"6575","first_page":"630","last_page":"633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.9940000176429749},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ige-class-switching","display_name":"IgE class switching","score":0.890999972820282},{"id":"https://openalex.org/keywords/immunoglobulin-isotype-switching","display_name":"immunoglobulin isotype switching","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gene-disruption","display_name":"gene disruption","score":0.5960000157356262},{"id":"https://openalex.org/keywords/t-helper-cell-differentiation","display_name":"T helper cell differentiation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lymphoid-development","display_name":"lymphoid development","score":0.7480000257492065},{"id":"https://openalex.org/keywords/signal-transducer-and-activator-of-transcription","display_name":"signal transducer and activator of transcription","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C145430368","wikidata":"https://www.wikidata.org/wiki/Q14914613","display_name":"STAT6","level":4,"score":0.7646613717079163},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.7395188808441162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.676169216632843},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.6126865148544312},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5682714581489563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5019736289978027},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.4766586422920227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4687231779098511},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4461558163166046},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4408726394176483},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4395192265510559},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.4110877811908722},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36832380294799805},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3152303695678711},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3143649697303772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31242531538009644},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26401597261428833},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.18668323755264282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1412639319896698},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.12937051057815552}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017578","descriptor_name":"Immunoglobulin Class Switching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/380630a0","doi":"https://doi.org/10.1038/380630a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/380630a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:8602264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8602264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W44416003","https://openalex.org/W63754614","https://openalex.org/W1601600505","https://openalex.org/W1610618731","https://openalex.org/W1634158134","https://openalex.org/W1845629018","https://openalex.org/W1882823390","https://openalex.org/W1964815717","https://openalex.org/W1987758746","https://openalex.org/W1995297089","https://openalex.org/W1997531619","https://openalex.org/W2012408584","https://openalex.org/W2015045029","https://openalex.org/W2028699958","https://openalex.org/W2029275361","https://openalex.org/W2029836713","https://openalex.org/W2037061225","https://openalex.org/W2038881740","https://openalex.org/W2052172628","https://openalex.org/W2052779439","https://openalex.org/W2067049479","https://openalex.org/W2079357798","https://openalex.org/W2086715846","https://openalex.org/W2093822115","https://openalex.org/W2122506044","https://openalex.org/W2142625689","https://openalex.org/W2165588484","https://openalex.org/W2173560213"],"related_works":["https://openalex.org/W2029860358","https://openalex.org/W2064719711","https://openalex.org/W4242137162","https://openalex.org/W2001713238","https://openalex.org/W7101103158","https://openalex.org/W2116457898","https://openalex.org/W1653542284","https://openalex.org/W1500581281","https://openalex.org/W2110552598","https://openalex.org/W7100717394"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}