{"id":"https://openalex.org/W2002184575","doi":"https://doi.org/10.2298/sarh0202019v","title":"Pragmatic study of efficiency of controlled-release carbamazepine (TEGRETOL CR 400) in the treatment of patients with partial seizures","display_name":"Pragmatic study of efficiency of controlled-release carbamazepine (TEGRETOL CR 400) in the treatment of patients with partial seizures","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2002184575","doi":"https://doi.org/10.2298/sarh0202019v","mag":"2002184575","pmid":"https://pubmed.ncbi.nlm.nih.gov/12073283"},"language":"en","primary_location":{"id":"doi:10.2298/sarh0202019v","doi":"https://doi.org/10.2298/sarh0202019v","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh0202019v","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81790202019V","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81790202019V","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034526330","display_name":"Nikola M. Vojvodi\u0107","orcid":"https://orcid.org/0000-0002-8433-0319","observed_orcids":["https://orcid.org/0000-0002-8433-0319"]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nikola Vojvodic","raw_affiliation_strings":["Institut za neurologiju Klini\u010dkog centra Srbije, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut za neurologiju Klini\u010dkog centra Srbije, Beograd","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009826939","display_name":"Dragoslav V. Soki\u0107","orcid":"https://orcid.org/0000-0003-0226-9727","observed_orcids":["https://orcid.org/0000-0003-0226-9727"]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Dragoslav Sokic","raw_affiliation_strings":["Institut za neurologiju Klini\u010dkog centra Srbije, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut za neurologiju Klini\u010dkog centra Srbije, Beograd","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103688114","display_name":"Slavko M. Jankovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Slavko Jankovic","raw_affiliation_strings":["Institut za neurologiju Klini\u010dkog centra Srbije, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut za neurologiju Klini\u010dkog centra Srbije, Beograd","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082784457","display_name":"Z Levi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Zvonimir Levic","raw_affiliation_strings":["Institut za neurologiju Klini\u010dkog centra Srbije, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut za neurologiju Klini\u010dkog centra Srbije, Beograd","institution_ids":["https://openalex.org/I4210113171"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210113171"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"130","issue":"1-2","first_page":"19","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/controlled-release-formulation","display_name":"controlled-release formulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/focal-seizures","display_name":"focal seizures","score":0.9729999899864197},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/antiepileptic-drug-efficacy","display_name":"antiepileptic drug efficacy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7229999899864197},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.671999990940094},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.5180000066757202},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.3409999907016754},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5360000133514404},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.3869999945163727},{"id":"https://openalex.org/keywords/adult-epilepsy","display_name":"adults with epilepsy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/pragmatic-clinical-trials","display_name":"pragmatic trials","score":0.48899999260902405},{"id":"https://openalex.org/keywords/seizure-frequency-reduction","display_name":"seizure frequency reduction","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.9790090918540955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8997215032577515},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7147195935249329},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.657684862613678},{"id":"https://openalex.org/C2777803345","wikidata":"https://www.wikidata.org/wiki/Q7140388","display_name":"partial seizures","level":3,"score":0.6166407465934753},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.5594063997268677},{"id":"https://openalex.org/C3019985608","wikidata":"https://www.wikidata.org/wiki/Q7140388","display_name":"Partial epilepsy","level":3,"score":0.5054261684417725},{"id":"https://openalex.org/C2994127763","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Antiepileptic drug","level":3,"score":0.49298760294914246},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.48320138454437256},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4654126465320587},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3359152376651764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29344797134399414},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06643801927566528}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2298/sarh0202019v","doi":"https://doi.org/10.2298/sarh0202019v","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh0202019v","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81790202019V","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},{"id":"pmid:12073283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12073283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:8f42fd484ab64952aea5c27968c83cfc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f42fd484ab64952aea5c27968c83cfc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Srpski Arhiv za Celokupno Lekarstvo, Vol 130, Iss 1-2, Pp 19-26 (2002)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2298/sarh0202019v","doi":"https://doi.org/10.2298/sarh0202019v","is_oa":true,"landing_page_url":"https://doi.org/10.2298/sarh0202019v","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81790202019V","source":{"id":"https://openalex.org/S69759517","display_name":"Srpski arhiv za celokupno lekarstvo","issn_l":"0370-8179","issn":["0370-8179","2406-0895"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Srpski arhiv za celokupno lekarstvo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2002184575.pdf"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1970652510","https://openalex.org/W1999867084","https://openalex.org/W2047392559","https://openalex.org/W2062806622","https://openalex.org/W2065279756","https://openalex.org/W2072484888","https://openalex.org/W2093150341","https://openalex.org/W2102023851","https://openalex.org/W2132785864","https://openalex.org/W4239594659","https://openalex.org/W4247932988","https://openalex.org/W4251662319"],"related_works":["https://openalex.org/W2145097587","https://openalex.org/W2031707513","https://openalex.org/W2431118687","https://openalex.org/W1975940543","https://openalex.org/W4229835840","https://openalex.org/W7217586639","https://openalex.org/W2034535434","https://openalex.org/W2059376977","https://openalex.org/W1978983959","https://openalex.org/W2029089993"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Carbamazepine":[1],"(CBZ)":[2],"is":[3],"the":[4,10,27,78,84,114,195,203,211,259,275,297,334,381,384,413],"first":[5],"choice":[6],"antiepileptic":[7,161,186],"drug":[8,344],"in":[9,26,50,89,113,236,301,309,317,329,350,370,404],"treatment":[11],"of":[12,24,29,42,62,72,83,86,110,116,123,173,205,210,217,232,240,261,266,281,286,343,352,383,396,415,434],"partial":[13,87,446],"seizures.":[14],"Many":[15],"clinical":[16],"studies":[17],"show":[18],"high":[19],"efficacy":[20],"and":[21,35,47,81,142,158,176,194,208,238,242,254,264,305,313,315,321,360,367,392,401,428,463],"good":[22],"tolerance":[23,80,207],"CBZ":[25,51,63,93,112,193,213,290,373,397],"majority":[28,414],"patients.":[30,354],"However,":[31],"poor":[32],"water":[33],"solubility":[34],"erratic":[36],"absorption":[37,400],"as":[38,40,388,431],"well":[39],"autoinduction":[41],"its":[43,358],"metabolism,":[44],"cause":[45],"wide":[46,366],"unpredictable":[48,368],"fluctuations":[49,403],"serum":[52,406,409],"concentration.":[53,407],"In":[54,293,443],"order":[55],"to":[56,76,191,274,357,377,412,417],"avoid":[57],"these":[58],"problems":[59],"controlled-release":[60,92,111,192,212,251,289,337,448],"formulations":[61],"(Tegretol":[64,94],"CR":[65,95],"400)":[66],"were":[67,134,143,189,219,256,272],"developed.":[68],"PURPOSE:":[69],"The":[70],"aim":[71],"this":[73],"study":[74,109],"was":[75,197,299],"evaluate":[77],"efficacy,":[79,206],"practicality":[82,209],"therapy":[85,115,245,298,335],"seizures":[88,447],"adults":[90],"with":[91,120,128,150,155,165,170,179,184,230,336,380,445],"400).":[96],"PATIENTS":[97],"AND":[98],"METHODS:":[99],"Over":[100],"a":[101,279,419,432],"three-year":[102],"period":[103,280],"we":[104],"conducted":[105],"an":[106,457],"open":[107],"pragmatic":[108],"141":[117],"adult":[118],"patients":[119,137,416,444],"established":[121],"diagnosis":[122],"localized":[124],"related":[125],"epilepsy.":[126],"Patients":[127,188],"progressive":[129],"brain":[130],"or":[131,247,347,440],"systemic":[132],"disease":[133],"excluded.":[135],"All":[136],"had":[138,452],"unacceptable":[139],"seizure":[140],"frequency":[141,237,265,342],"divided":[144],"into":[145],"four":[146,295],"groups:":[147],"1)":[148,221],"34":[149],"newly-diagnosed":[151],"epilepsy;":[152],"2)":[153,226],"42":[154],"chronic":[156,166,180],"epilepsy":[157,167,181],"no":[159],"previous":[160],"medication;":[162],"3)":[163,243],"27":[164],"previously":[168,182],"treated":[169,183],"conventional":[171,450],"preparations":[172],"carbamazepine":[174,405,451],"(CBZ);":[175],"4)":[177],"38":[178],"other":[185],"medications.":[187],"switched":[190],"dosage":[196,288,462],"slowly":[198],"adjusted.":[199],"Baseline":[200],"evaluation":[201],"included":[202],"analysis":[204,260],"therapy.":[214,291],"Three":[215],"categories":[216],"efficiency":[218],"defined:":[220],"successful":[222,228,300,308],"(patients":[223,229],"without":[224],"seizures);":[225,241],"partially":[227,307],"improvement":[231],"at":[233,282],"least":[234,283],"50%":[235],"severity":[239],"unsuccessful":[244,316],"(same":[246],"worse":[248],"than":[249],"before":[250],"CBZ).":[252],"Tolerance":[253],"practicity":[255],"evaluated":[257],"through":[258],"side":[262],"effects":[263,325],"daily":[267,422,437,461],"doses,":[268],"respectively.":[269],"These":[270],"variables":[271],"compared":[273],"corresponding":[276],"ones":[277],"after":[278],"three":[284],"months":[285],"full":[287],"RESULTS:":[292],"all":[294,330],"groups":[296,332],"76%,":[302],"52%,":[303],"30%":[304,312],"29%,":[306],"18%,":[310],"43%,":[311],"32%,":[314],"6%,":[318],"S%,":[319],"40%":[320],"39%,":[322],"respectfully.":[323],"Side":[324],"occurred":[326],"less":[327,435],"frequently":[328],"4":[331],"during":[333],"CBZ.":[338],"We":[339],"found":[340],"reduced":[341],"administration":[345],"(once":[346],"twice":[348],"daily)":[349],"97.9%":[351],"our":[353],"DISCUSSION:":[355],"Due":[356],"slow":[359],"irregular":[361],"absorption,":[362],"short":[363],"half":[364],"life,":[365],"fluctuation":[369],"plasma":[371],"levels":[372,410],"has":[374],"decreased":[375],"ability":[376],"control":[378],"seizures,":[379],"appearance":[382],"intermittent":[385],"side-effects":[386,427],"such":[387],"diplopia,":[389],"ataxia,":[390],"headache":[391],"dizziness.":[393],"Controlled-release":[394],"formulation":[395],"sustains":[398],"stable":[399],"reduces":[402],"Steady":[408],"permit":[411],"tolerate":[418],"higher":[420],"total":[421],"dose":[423],"by":[424],"reducing":[425],"peak-dependent":[426],"improve":[429],"compliance":[430],"result":[433],"frequent":[436],"doses":[438],"(1":[439],"2).":[441],"CONCLUSION:":[442],"vs.":[449],"better":[453],"efficiency,":[454],"based":[455],"on":[456],"excellent":[458],"tolerance,":[459],"favorable":[460],"superior":[464],"compliance.":[465]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}