{"id":"https://openalex.org/W2002173682","doi":"https://doi.org/10.1002/mabi.200900230","title":"A Novel Temperature\u2010Responsive Polymer as a Gene Vector","display_name":"A Novel Temperature\u2010Responsive Polymer as a Gene Vector","publication_year":2009,"publication_date":"2009-11-10","ids":{"openalex":"https://openalex.org/W2002173682","doi":"https://doi.org/10.1002/mabi.200900230","mag":"2002173682","pmid":"https://pubmed.ncbi.nlm.nih.gov/19904723"},"language":"en","primary_location":{"id":"doi:10.1002/mabi.200900230","doi":"https://doi.org/10.1002/mabi.200900230","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mabi.200900230","pdf_url":null,"source":{"id":"https://openalex.org/S182383103","display_name":"Macromolecular Bioscience","issn_l":"1616-5187","issn":["1616-5187","1616-5195"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088444614","display_name":"Yongzheng Ma","orcid":"https://orcid.org/0000-0003-3484-7560","observed_orcids":["https://orcid.org/0000-0003-3484-7560"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzheng Ma","raw_affiliation_strings":["The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017257088","display_name":"Sen Hou","orcid":"https://orcid.org/0000-0002-6871-4419","observed_orcids":["https://orcid.org/0000-0002-6871-4419"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sen Hou","raw_affiliation_strings":["The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101543206","display_name":"Bin Ji","orcid":"https://orcid.org/0000-0002-4957-4991","observed_orcids":["https://orcid.org/0000-0002-4957-4991"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Ji","raw_affiliation_strings":["The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109955965","display_name":"Yao Yang","orcid":"https://orcid.org/0009-0005-2521-339X","observed_orcids":["https://orcid.org/0009-0005-2521-339X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yao","raw_affiliation_strings":["The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015833949","display_name":"Xizeng Feng","orcid":"https://orcid.org/0000-0002-8842-8428","observed_orcids":["https://orcid.org/0000-0002-8842-8428"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xizeng Feng","raw_affiliation_strings":["The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015833949"],"corresponding_institution_ids":["https://openalex.org/I205237279"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.9889,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71060976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"202","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermoresponsive-polymers","display_name":"thermoresponsive polymers","score":0.9490000009536743},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lower-critical-solution-temperature","display_name":"lower critical solution temperature","score":0.8190000057220459},{"id":"https://openalex.org/keywords/poly-n-isopropylacrylamide","display_name":"poly(N-isopropylacrylamide)","score":0.902999997138977},{"id":"https://openalex.org/keywords/pdmaema","display_name":"PDMAEMA","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C188109995","wikidata":"https://www.wikidata.org/wiki/Q1645085","display_name":"Lower critical solution temperature","level":4,"score":0.9342718124389648},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.7823362350463867},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.7263964414596558},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.6888518333435059},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.6264398097991943},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.6200540065765381},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6057318449020386},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5015356540679932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48143598437309265},{"id":"https://openalex.org/C111998727","wikidata":"https://www.wikidata.org/wiki/Q2620998","display_name":"Radical polymerization","level":4,"score":0.46086016297340393},{"id":"https://openalex.org/C120456961","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Light scattering","level":3,"score":0.43081581592559814},{"id":"https://openalex.org/C191516044","wikidata":"https://www.wikidata.org/wiki/Q662950","display_name":"Degree of polymerization","level":4,"score":0.4196263551712036},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4128200113773346},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36993616819381714},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.34967631101608276},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.3398325443267822},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.3309248089790344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1676344871520996},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1656126081943512},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12872982025146484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07127466797828674},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mabi.200900230","doi":"https://doi.org/10.1002/mabi.200900230","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mabi.200900230","pdf_url":null,"source":{"id":"https://openalex.org/S182383103","display_name":"Macromolecular Bioscience","issn_l":"1616-5187","issn":["1616-5187","1616-5195"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Bioscience","raw_type":"journal-article"},{"id":"pmid:19904723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19904723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular bioscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1483766007","https://openalex.org/W1973174294","https://openalex.org/W1975600099","https://openalex.org/W1989868163","https://openalex.org/W1992912553","https://openalex.org/W1994846102","https://openalex.org/W2003414091","https://openalex.org/W2005521877","https://openalex.org/W2013502397","https://openalex.org/W2021189478","https://openalex.org/W2025471675","https://openalex.org/W2025767738","https://openalex.org/W2037095384","https://openalex.org/W2054879058","https://openalex.org/W2058391956","https://openalex.org/W2064103991","https://openalex.org/W2067345253","https://openalex.org/W2079100326","https://openalex.org/W2084964693","https://openalex.org/W2085700560","https://openalex.org/W2086621612","https://openalex.org/W2086743439","https://openalex.org/W2087366454","https://openalex.org/W2092850986","https://openalex.org/W2094901720","https://openalex.org/W2140705889","https://openalex.org/W2143729842","https://openalex.org/W2144081123","https://openalex.org/W2147074779","https://openalex.org/W2162029104"],"related_works":["https://openalex.org/W2087366454","https://openalex.org/W2065121518","https://openalex.org/W2009314066","https://openalex.org/W2154441993","https://openalex.org/W2085700560","https://openalex.org/W2137821067","https://openalex.org/W1994846102","https://openalex.org/W2769580039","https://openalex.org/W2104007357","https://openalex.org/W2159300091"],"abstract_inverted_index":{"A":[0],"temperature-responsive":[1,19],"polymer":[2,15],"poly{2-(dimethylamino)ethyl":[3],"methacrylate-co-[cis-butenedioic":[4],"anhydride-poly[(N-isopropylacrylamide)-co-(butyl":[5],"methacrylate)]]}":[6],"(PDMNIB)":[7],"was":[8],"synthesized":[9],"by":[10,68,88],"free":[11],"radical":[12],"polymerization.":[13],"The":[14],"had":[16],"a":[17,22],"significant":[18],"behavior":[20],"with":[21,41],"lower":[23],"critical":[24],"solution":[25],"temperature":[26],"(LCST)":[27],"at":[28],"20":[29],"degrees":[30],"C.":[31],"Gel":[32],"retardation":[33],"assay":[34],"showed":[35],"that":[36,52],"PDMNIB":[37,76,84],"could":[38,65,85],"efficiently":[39],"interact":[40],"DNA.":[42],"Dynamic":[43],"light":[44],"scattering":[45],"(DLS)":[46],"and":[47,56,77],"zeta":[48],"potential":[49],"measurement":[50],"indicated":[51],"the":[53,57,62,72,79],"average":[54],"sizes":[55],"surface":[58],"electric":[59],"charges":[60],"of":[61,83],"PDMNIB/DNA":[63],"complexes":[64],"be":[66,86],"changed":[67],"temperature.":[69,89],"Due":[70],"to":[71],"thermosensitive":[73],"interaction":[74],"between":[75],"DNA,":[78],"gene":[80],"transfection":[81],"efficiency":[82],"improved":[87]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}