{"id":"https://openalex.org/W2002173586","doi":"https://doi.org/10.1002/cncr.23371","title":"Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions","display_name":"Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions","publication_year":2008,"publication_date":"2008-02-29","ids":{"openalex":"https://openalex.org/W2002173586","doi":"https://doi.org/10.1002/cncr.23371","mag":"2002173586","pmid":"https://pubmed.ncbi.nlm.nih.gov/18311783"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.23371","doi":"https://doi.org/10.1002/cncr.23371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23371","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054433435","display_name":"Altaf A. Dar","orcid":"https://orcid.org/0000-0003-4891-3039","observed_orcids":["https://orcid.org/0000-0003-4891-3039"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Altaf A. Dar","raw_affiliation_strings":["Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA","Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032514998","display_name":"Alexander I. Zaika","orcid":"https://orcid.org/0000-0001-6760-2020","observed_orcids":["https://orcid.org/0000-0001-6760-2020"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Zaika","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee","Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000074569","display_name":"Maria Blanca Piazuelo","orcid":"https://orcid.org/0000-0002-0000-1324","observed_orcids":["https://orcid.org/0000-0002-0000-1324"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria B. Piazuelo","raw_affiliation_strings":["Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111605658","display_name":"Pelayo Correa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pelayo Correa","raw_affiliation_strings":["Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048600723","display_name":"Tatsuki Koyama","orcid":"https://orcid.org/0000-0002-8908-9165","observed_orcids":["https://orcid.org/0000-0002-8908-9165"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatsuki Koyama","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee","\u2020Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"\u2020Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004330175","display_name":"Abbes Belkhiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abbes Belkhiri","raw_affiliation_strings":["Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee","Department of Surgery, Vanderbilt University Medical Center, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113808153","display_name":"Kay M. Washington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kay Washington","raw_affiliation_strings":["Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee","Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee;","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047762415","display_name":"Antoni Castells","orcid":"https://orcid.org/0000-0001-8431-2033","observed_orcids":["https://orcid.org/0000-0001-8431-2033"]},"institutions":[{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antoni Castells","raw_affiliation_strings":["Department of Gastroenterology , University of Barcelona (IDIBAPS) , Barcelona , Spain","Department of Gastroenterology, University of Barcelona (IDIBAPS), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology , University of Barcelona (IDIBAPS) , Barcelona , Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Gastroenterology, University of Barcelona (IDIBAPS), Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014370129","display_name":"Manuel Pera","orcid":"https://orcid.org/0000-0002-9449-1810","observed_orcids":["https://orcid.org/0000-0002-9449-1810"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Pera","raw_affiliation_strings":["Section of Gastrointestinal Surgery , Hospital Clinic , CIBERehd , University of Barcelona (IDI- BAPS) , Barcelona , Spain","Section of Gastrointestinal Surgery, Hospital Clinic, CIBERehd, University of Barcelona (IDIBAPS), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastrointestinal Surgery , Hospital Clinic , CIBERehd , University of Barcelona (IDI- BAPS) , Barcelona , Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210132431","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Section of Gastrointestinal Surgery, Hospital Clinic, CIBERehd, University of Barcelona (IDIBAPS), Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001099941","display_name":"Wael M. El-Rifai","orcid":"https://orcid.org/0000-0003-2101-6098","observed_orcids":["https://orcid.org/0000-0003-2101-6098"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wael El\u2010Rifai","raw_affiliation_strings":["Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":4.3361,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.94157245,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"112","issue":"8","first_page":"1688","last_page":"1698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.972000002861023},{"id":"https://openalex.org/keywords/upper-gastrointestinal-adenocarcinoma","display_name":"upper gastrointestinal adenocarcinoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/antiapoptotic-function","display_name":"antiapoptotic function","score":0.8920000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4959999918937683},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8169999718666077},{"id":"https://openalex.org/keywords/p53-transcriptional-activity","display_name":"p53 transcriptional activity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.777999997138977},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.9729999899864197},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6051071882247925},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5844289064407349},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5838629603385925},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.49885988235473633},{"id":"https://openalex.org/C2780808130","wikidata":"https://www.wikidata.org/wiki/Q24745285","display_name":"Aurora kinase","level":4,"score":0.4979550838470459},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48941078782081604},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4855506122112274},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4540397524833679},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.44637688994407654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43613579869270325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39626142382621765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3890620172023773},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3277990221977234},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29616498947143555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15561828017234802},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1275460124015808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D049408","descriptor_name":"Luminescent Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049408","descriptor_name":"Luminescent Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049408","descriptor_name":"Luminescent Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.23371","doi":"https://doi.org/10.1002/cncr.23371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23371","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:18311783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18311783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:3005292","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC4030394","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4030394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030394","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cncr.23371","doi":"https://doi.org/10.1002/cncr.23371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23371","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1963234142","display_name":null,"funder_award_id":"R01 CA106176","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3568840337","display_name":null,"funder_award_id":"CA95103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4841106333","display_name":"SPORE in GI Cancer","funder_award_id":"P50CA095103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002173586.pdf","grobid_xml":"https://content.openalex.org/works/W2002173586.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W143868869","https://openalex.org/W1596652845","https://openalex.org/W1657157395","https://openalex.org/W1665081245","https://openalex.org/W1954313480","https://openalex.org/W1963592300","https://openalex.org/W1984507712","https://openalex.org/W1989537346","https://openalex.org/W1990317973","https://openalex.org/W1997845311","https://openalex.org/W2003605454","https://openalex.org/W2017467516","https://openalex.org/W2033923680","https://openalex.org/W2040143851","https://openalex.org/W2040588244","https://openalex.org/W2043539450","https://openalex.org/W2046024015","https://openalex.org/W2048121649","https://openalex.org/W2056530510","https://openalex.org/W2071156666","https://openalex.org/W2075000991","https://openalex.org/W2080493618","https://openalex.org/W2083582547","https://openalex.org/W2092817294","https://openalex.org/W2092902276","https://openalex.org/W2093549611","https://openalex.org/W2093877987","https://openalex.org/W2104756411","https://openalex.org/W2106942695","https://openalex.org/W2116635868","https://openalex.org/W2117035457","https://openalex.org/W2135436234","https://openalex.org/W2137429755","https://openalex.org/W2149814771","https://openalex.org/W2158160769","https://openalex.org/W2165454946","https://openalex.org/W2170710435","https://openalex.org/W2338576041","https://openalex.org/W2796677525","https://openalex.org/W4211113621","https://openalex.org/W4254765132"],"related_works":["https://openalex.org/W3103789129","https://openalex.org/W2924722371","https://openalex.org/W4213065871","https://openalex.org/W4386799875","https://openalex.org/W3157667906","https://openalex.org/W4361818220","https://openalex.org/W4361818978","https://openalex.org/W2001495175","https://openalex.org/W2057390952","https://openalex.org/W2163499613"],"abstract_inverted_index":{"BACKGROUND:":[0],"Upper":[1],"gastrointestinal":[2,30,57,107,133,158,261],"adenocarcinomas":[3,108],"are":[4],"a":[5,139,202,211,222],"common":[6],"cause":[7],"of":[8,22,53,66,102,121,127,131,151,182,192,214,218,229,239,266],"cancer-related":[9],"deaths.":[10],"In":[11],"this":[12,198],"study,":[13],"the":[14,17,51,61,68,145,149,206,226,269],"authors":[15,69,146],"investigated":[16],"prevalence":[18],"and":[19,39,63,95,162,166,200,236,248],"biological":[20,62],"significance":[21],"Aurora":[23],"Kinase":[24],"A":[25],"(AURKA)":[26],"overexpression":[27,101,176,217],"in":[28,55,72,105,129,142,180,187,194,205,225,234],"upper":[29,56,106,132],"adenocarcinomas.":[31,58,134],"METHODS:":[32],"Quantitative":[33],"real-time":[34],"polymerase":[35],"chain":[36],"reaction":[37],"(qRT-PCR)":[38],"immunohistochemical":[40,119],"staining":[41],"on":[42],"tumor":[43],"tissue":[44],"microarrays":[45],"(TMA)":[46],"were":[47],"used":[48,70],"to":[49,157,221,260],"study":[50],"expression":[52,150],"AURKA":[54,103,128,152,175,219,255],"To":[59],"investigate":[60],"signaling":[64],"impact":[65],"AURKA,":[67],"multiple":[71],"vitro":[73,143],"assays":[74],"that":[75,148,254],"included":[76],"3-(4,":[77],"5-dimethylthiazol-2-yl)-2,":[78],"5-diphenyltetrazolium":[79],"bromide":[80],"(MTT),":[81],"TUNEL":[82],"(terminal":[83],"deoxynucleotidyl":[84],"transferase-mediated":[85],"nick-end":[86],"labeling),":[87],"cytochrome":[88],"C":[89],"release,":[90],"flow":[91],"cytometry,":[92],"luciferase":[93],"reporter,":[94],"Western":[96],"blot":[97],"analysis.":[98],"RESULTS:":[99],"Frequent":[100],"transcript":[104,235],"was":[109],"detected":[110],"compared":[111],"with":[112,184,231],"normal":[113],"samples":[114],"(47%;":[115],"P=":[116],".001).":[117,173],"The":[118,174,190],"analysis":[120],"130":[122],"tumors":[123],"demonstrated":[124,147],"moderate-to-strong":[125],"immunostaining":[126],">50%":[130],"By":[135],"using":[136],"camptothecin":[137],"as":[138],"drug-induced":[140],"apoptosis":[141,156],"model,":[144],"provided":[153],"protection":[154],"against":[155],"cancer":[159],"cells":[160,171,196,262],"(AGS":[161],"RKO)":[163],"(P=":[164,172],".006)":[165],"RIE-1":[167],"primary":[168],"intestinal":[169],"epithelial":[170],"mediated":[177],"an":[178,185],"increase":[179,186,204],"phosphorylation":[181],"AKT(Ser473)":[183],"HDM2":[188],"level.":[189],"shRNA-knockdown":[191],"AKT":[193],"AURKA-overexpressing":[195],"reversed":[197],"effect":[199],"showed":[201],"significant":[203],"p53":[207,267],"protein":[208,237],"level,":[209],"indicating":[210],"possible":[212],"nexus":[213],"AURKA/AKT/p53.":[215],"Indeed,":[216],"led":[220],"remarkable":[223],"reduction":[224],"transcription":[227,243],"activity":[228],"p53,":[230],"subsequent":[232],"reductions":[233],"levels":[238,265],"its":[240],"downstream":[241],"proapoptotic":[242],"targets":[244],"(p21,":[245],"BAX,":[246],"NOXA,":[247],"PUMA).":[249],"CONCLUSIONS:":[250],"Study":[251],"results":[252],"indicated":[253],"provides":[256],"potent":[257],"antiapoptotic":[258],"properties":[259],"by":[263],"regulating":[264],"through":[268],"AKT/HDM2":[270],"axis.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
