{"id":"https://openalex.org/W2002173046","doi":"https://doi.org/10.1016/j.febslet.2007.05.077","title":"The hypoxia\u2010inducible factor is stabilized in circulating hematopoietic stem cells under normoxic conditions","display_name":"The hypoxia\u2010inducible factor is stabilized in circulating hematopoietic stem cells under normoxic conditions","publication_year":2007,"publication_date":"2007-06-06","ids":{"openalex":"https://openalex.org/W2002173046","doi":"https://doi.org/10.1016/j.febslet.2007.05.077","mag":"2002173046","pmid":"https://pubmed.ncbi.nlm.nih.gov/17568584"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2007.05.077","doi":"https://doi.org/10.1016/j.febslet.2007.05.077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.05.077","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.05.077","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.05.077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046309539","display_name":"Cl\u00e1udia Piccoli","orcid":"https://orcid.org/0000-0001-9739-4680","observed_orcids":["https://orcid.org/0000-0001-9739-4680"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Piccoli","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077822050","display_name":"Annamaria D\u2019Aprile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annamaria D'Aprile","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001084592","display_name":"Maria Cristina Ripoli","orcid":"https://orcid.org/0000-0002-8132-0764","observed_orcids":["https://orcid.org/0000-0002-8132-0764"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Ripoli","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008558621","display_name":"Rosella Scrima","orcid":"https://orcid.org/0000-0002-2061-4988","observed_orcids":["https://orcid.org/0000-0002-2061-4988"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosella Scrima","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018978340","display_name":"Domenico Boffoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Boffoli","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065136717","display_name":"Antonio Tabilio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Tabilio","raw_affiliation_strings":["Department of Internal Medicine and Public Health, Internal Medicine and Hematology Unit, University of L'Aquila, L'Aquila, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Public Health, Internal Medicine and Hematology Unit, University of L'Aquila, L'Aquila, Italy","institution_ids":["https://openalex.org/I26415053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039786016","display_name":"Nazzareno Capitanio","orcid":"https://orcid.org/0000-0001-9285-051X","observed_orcids":["https://orcid.org/0000-0001-9285-051X"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Nazzareno Capitanio","raw_affiliation_strings":["Department of Biomedical Science, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039786016"],"corresponding_institution_ids":["https://openalex.org/I106296451"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.8785,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.87507528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"581","issue":"16","first_page":"3111","last_page":"3119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hif-1alpha-stabilization","display_name":"HIF-1\u03b1 stabilization","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/normoxia","display_name":"normoxia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/von-hippel-lindau-protein","display_name":"von Hippel-Lindau protein","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cd133-cells","display_name":"CD133+ cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor-mobilization","display_name":"granulocyte colony-stimulating factor mobilization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ischemic-tissue-repair","display_name":"ischemic tissue repair","score":0.7749999761581421},{"id":"https://openalex.org/keywords/stem-cell-maintenance","display_name":"stem cell maintenance","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.733971357345581},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6799612045288086},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.608989953994751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5372006893157959},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.4953290522098541},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43545085191726685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41554445028305054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2976541519165039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2659945785999298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10916781425476074},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0963267982006073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.febslet.2007.05.077","doi":"https://doi.org/10.1016/j.febslet.2007.05.077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.05.077","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.05.077","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:17568584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17568584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:fair.unifg.it:11369/371074","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11369/371074","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zenodo.org:151750","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/151750","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2007.05.077","doi":"https://doi.org/10.1016/j.febslet.2007.05.077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.05.077","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.05.077","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316353","display_name":"Universit\u00e0 degli Studi di Foggia","ror":"https://ror.org/01xtv3204"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002173046.pdf","grobid_xml":"https://content.openalex.org/works/W2002173046.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W192938927","https://openalex.org/W1524979313","https://openalex.org/W1545825939","https://openalex.org/W1586334233","https://openalex.org/W1749022239","https://openalex.org/W1967351404","https://openalex.org/W1975984062","https://openalex.org/W1982861439","https://openalex.org/W1990574061","https://openalex.org/W1999335215","https://openalex.org/W1999956601","https://openalex.org/W2002248781","https://openalex.org/W2002650023","https://openalex.org/W2005258127","https://openalex.org/W2005868568","https://openalex.org/W2006079390","https://openalex.org/W2006082939","https://openalex.org/W2011653215","https://openalex.org/W2012479859","https://openalex.org/W2015644147","https://openalex.org/W2024229944","https://openalex.org/W2045459881","https://openalex.org/W2048334451","https://openalex.org/W2050489252","https://openalex.org/W2053650018","https://openalex.org/W2057677145","https://openalex.org/W2057896668","https://openalex.org/W2063441735","https://openalex.org/W2071203020","https://openalex.org/W2073292880","https://openalex.org/W2080374319","https://openalex.org/W2080789499","https://openalex.org/W2091806012","https://openalex.org/W2098972920","https://openalex.org/W2104551938","https://openalex.org/W2118484233","https://openalex.org/W2126244927","https://openalex.org/W2135034560","https://openalex.org/W2144419407","https://openalex.org/W2151870428","https://openalex.org/W2166381187","https://openalex.org/W2235927674","https://openalex.org/W2317548431"],"related_works":["https://openalex.org/W1988501733","https://openalex.org/W2593939338","https://openalex.org/W2154239129","https://openalex.org/W2113874362","https://openalex.org/W1974549729","https://openalex.org/W645939569","https://openalex.org/W2029306864","https://openalex.org/W2056351644","https://openalex.org/W1585084910","https://openalex.org/W2068141056"],"abstract_inverted_index":{"The":[0,48],"hypoxia-inducible":[1],"factor":[2],"(HIF)":[3],"transcriptional":[4],"system":[5],"enables":[6],"cell":[7,32,143],"adaptation":[8],"to":[9,42,54,145],"limited":[10],"O(2)":[11],"availability,":[12],"transducing":[13],"this":[14,44,51],"signal":[15],"into":[16],"patho-physiological":[17],"responses":[18],"such":[19],"as":[20,29,31,138],"angiogenesis,":[21],"erythropoiesis,":[22],"vasomotor":[23],"control,":[24],"and":[25,63,73,102],"altered":[26],"energy":[27],"metabolism,":[28],"well":[30],"survival":[33],"decisions.":[34],"However,":[35],"other":[36],"factors":[37],"beyond":[38],"hypoxia":[39],"are":[40],"known":[41],"activate":[43],"pleiotropic":[45],"transcription":[46],"factor.":[47],"aim":[49],"of":[50,80,94,109,119,132,136,141,153,156],"study":[52],"was":[53],"characterize":[55],"HIF":[56,120,137],"in":[57,121,129,150],"human":[58],"hematopoietic":[59],"stem":[60],"cells":[61],"(HSCs)":[62],"evidence":[64],"is":[65,86,103,127],"provided":[66],"that":[67,88],"granulocyte":[68],"colony":[69],"stimulating":[70],"factor-mobilized":[71],"CD34+-":[72],"CD133+-HSCs":[74],"express":[75],"a":[76,114,139],"stabilized":[77],"cytoplasmic":[78],"form":[79],"HIF-1alpha":[81,89],"under":[82],"normoxic":[83],"conditions.":[84],"It":[85],"shown":[87],"stabilization":[90],"correlates":[91],"with":[92],"down-regulation":[93],"the":[95,130,133,151,154,157],"tumour":[96],"suppressor":[97],"von":[98],"Hippel-Lindau":[99],"protein":[100],"(pVHL)":[101],"positively":[104],"controlled":[105],"by":[106],"NADPH-oxidase-dependent":[107],"production":[108],"reactive":[110],"oxygen":[111],"species,":[112],"indicating":[113],"specific":[115],"O(2)-independent":[116],"post-transcriptional":[117],"control":[118,152],"mobilized":[122],"HSCs.":[123],"This":[124],"novel":[125],"finding":[126],"discussed":[128],"context":[131],"proposed":[134],"role":[135],"mediator":[140],"progenitor":[142],"recruitment":[144],"injured":[146],"ischemic":[147],"tissues":[148],"and/or":[149],"maintenance":[155],"undifferentiated":[158],"state.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}