{"id":"https://openalex.org/W2002170574","doi":"https://doi.org/10.1097/00024382-199904000-00003","title":"INHIBITORY KB\u03b1 CONTROL OF NUCLEAR FACTOR-KB IS DYSREGULATED IN ENDOTOXIN TOLERANT MACROPHAGES","display_name":"INHIBITORY KB\u03b1 CONTROL OF NUCLEAR FACTOR-KB IS DYSREGULATED IN ENDOTOXIN TOLERANT MACROPHAGES","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2002170574","doi":"https://doi.org/10.1097/00024382-199904000-00003","mag":"2002170574","pmid":"https://pubmed.ncbi.nlm.nih.gov/10220299"},"language":"en","primary_location":{"id":"doi:10.1097/00024382-199904000-00003","doi":"https://doi.org/10.1097/00024382-199904000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199904000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044114824","display_name":"Kyle Wahlstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Wahlstrom","raw_affiliation_strings":["Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415, USA","Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]},{"raw_affiliation_string":"Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017275365","display_name":"Janet M. Bellingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Bellingham","raw_affiliation_strings":["Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712997","display_name":"Jorge L. Rodriguez","orcid":"https://orcid.org/0000-0003-4506-3788","observed_orcids":["https://orcid.org/0000-0003-4506-3788"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge L. Rodriguez","raw_affiliation_strings":["Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076827794","display_name":"Michael A. West","orcid":"https://orcid.org/0000-0002-6598-4114","observed_orcids":["https://orcid.org/0000-0002-6598-4114"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. West","raw_affiliation_strings":["Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota 55415","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7416,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84693458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"242","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.39750000834465027,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endotoxin-tolerance","display_name":"endotoxin tolerance","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/p65-subunit","display_name":"p65 subunit","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.6809999942779541},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7160524129867554},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6421335935592651},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.624025285243988},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6092351675033569},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.5832165479660034},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5685302019119263},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5627857446670532},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5516324639320374},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5369678735733032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.522082507610321},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4827410578727722},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.4807474613189697},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4308796525001526},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34821948409080505},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29122194647789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23850220441818237},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22178098559379578},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00024382-199904000-00003","doi":"https://doi.org/10.1097/00024382-199904000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199904000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:10220299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10220299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3993815009","display_name":null,"funder_award_id":"GM 44764","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2042892987"],"related_works":["https://openalex.org/W2182730598","https://openalex.org/W2122708604","https://openalex.org/W2042852292","https://openalex.org/W2262107099","https://openalex.org/W4312920885","https://openalex.org/W2157856503","https://openalex.org/W2068587303","https://openalex.org/W2069686651","https://openalex.org/W2103629277","https://openalex.org/W1997564374"],"abstract_inverted_index":{"The":[0],"transcription":[1,102,157],"factor":[2,4,15,32],"nuclear":[3,127],"(NF)-kappaB":[5],"is":[6,26,184,206],"thought":[7],"to":[8,72,141],"be":[9],"required":[10],"for":[11,103],"endotoxin-stimulated":[12],"tumor":[13],"necrosis":[14],"(TNF)":[16],"and":[17,61,90,139,162],"interleukin":[18],"(IL)-1":[19],"gene":[20,156],"transcription.":[21],"Nuclear":[22],"translocation":[23,128,146,203],"of":[24,55,75,117,129,137,144,176,180,188,201],"NF-kappaB":[25,62,91,145,202],"regulated":[27],"by":[28,41,166,204],"the":[29,53,115,123,177],"cytoplasmic":[30,174,189],"inhibitory":[31],"IkappaBalpha.":[33],"Low-dose":[34],"lipopolysaccharide":[35],"(LPS)":[36],"pretreatment":[37,57],"modulates":[38],"cytokine":[39,155],"release":[40],"altering":[42],"subsequent":[43],"LPS-activated":[44],"signal":[45],"transduction":[46],"pathways.":[47],"In":[48,114],"this":[49,163],"study,":[50],"we":[51],"examined":[52],"effect":[54],"LPS":[56,76,84,99,110,118,152,167,182],"exposure":[58],"on":[59],"IkappaBalpha":[60,87,120,138,190,205],"following":[63],"activation":[64,111,153],"with":[65,81,126,147,186],"LPS.":[66],"Murine":[67],"macrophages":[68],"(Mphi":[69],"were":[70,94],"exposed":[71],"a":[73,148,159],"range":[74],"concentrations":[77],"+/-24":[78],"h":[79,108],"PreRx":[80],"10":[82],"ng/mL":[83],"pretreatment.":[85,168],"Cytoplasmic":[86],"(Western":[88],"immunoblot)":[89],"(gel-shift":[92],"assay)":[93],"assayed":[95],"30":[96],"min":[97],"after":[98,109],"activation.":[100],"Gene":[101],"TNF":[104],"was":[105,164],"measured":[106],"6":[107],"using":[112],"RT-PCR.":[113],"absence":[116],"pretreatment,":[119],"disappeared":[121],"from":[122],"cytoplasm":[124],"coincident":[125],"NF-kappaB.":[130,181,196],"Tolerant":[131],"Mphi":[132,170],"had":[133,172],"markedly":[134],"enhanced":[135,154,195],"levels":[136,143,175],"normal":[140],"increased":[142,173],"different":[149],"electrophoretic":[150],"shift.":[151],"in":[158,208],"dose-dependent":[160],"manner,":[161],"unaltered":[165],"Endotoxin-tolerant":[169],"also":[171],"p65":[178],"subunit":[179],"tolerance":[183],"associated":[185],"increases":[187],"p65,":[191],"as":[192,194],"well":[193],"We":[197],"conclude":[198],"that":[199],"control":[200],"dysregulated":[207],"endotoxin-tolerant":[209],"Mphi.":[210]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
