{"id":"https://openalex.org/W2002169724","doi":"https://doi.org/10.1002/gepi.20373","title":"More powerful haplotype sharing by accounting for the mode of inheritance","display_name":"More powerful haplotype sharing by accounting for the mode of inheritance","publication_year":2008,"publication_date":"2008-10-06","ids":{"openalex":"https://openalex.org/W2002169724","doi":"https://doi.org/10.1002/gepi.20373","mag":"2002169724","pmid":"https://pubmed.ncbi.nlm.nih.gov/18839399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2924681"},"language":"en","primary_location":{"id":"doi:10.1002/gepi.20373","doi":"https://doi.org/10.1002/gepi.20373","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.20373","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2924681/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039626163","display_name":"Andreas Ziegler","orcid":"https://orcid.org/0000-0002-8386-5397","observed_orcids":["https://orcid.org/0000-0002-8386-5397","https://orcid.org/0000-0002-6596-8333","https://orcid.org/0000-0001-7574-1231"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Ziegler","raw_affiliation_strings":["Institut f\u00fcr Medizinische Biometrie und Statistik, Universit\u00e4t zu L\u00fcbeck, L\u00fcbeck, Germany. ziegler@imbs.uni-luebeck.de","Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Medizinische Biometrie und Statistik, Universit\u00e4t zu L\u00fcbeck, L\u00fcbeck, Germany. ziegler@imbs.uni-luebeck.de","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079534481","display_name":"Adel Ewhida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23906160","display_name":"University of Tripoli","ror":"https://ror.org/00taa2s29","country_code":"LY","type":"education","lineage":["https://openalex.org/I23906160"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","LY"],"is_corresponding":false,"raw_author_name":"Adel Ewhida","raw_affiliation_strings":["Department of Statistics, Faculty of Science, Al-Fateh University, Tripoli, Libya","Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Faculty of Science, Al-Fateh University, Tripoli, Libya","institution_ids":["https://openalex.org/I23906160"]},{"raw_affiliation_string":"Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Brendel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Brendel","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Medical Data Services, 88397, Biberach, Germany","Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Medical Data Services, 88397, Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013042865","display_name":"Andr\u00e9 Kleensang","orcid":"https://orcid.org/0000-0002-4564-7399","observed_orcids":["https://orcid.org/0000-0002-4564-7399"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Kleensang","raw_affiliation_strings":["Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Medizinische Biometrie und Statistik, Universita\u0308t zu Lu\u0308beck, Lu\u0308beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039626163"],"corresponding_institution_ids":["https://openalex.org/I9341345"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.3025,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56655691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"33","issue":"3","first_page":"228","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haplotype-sharing","display_name":"haplotype sharing","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mode-of-inheritance","display_name":"mode of inheritance","score":0.9350000023841858},{"id":"https://openalex.org/keywords/recessive-inheritance","display_name":"recessive inheritance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dominant-inheritance","display_name":"dominant inheritance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-similarity","display_name":"genetic similarity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/phenotypic-similarity","display_name":"phenotypic similarity","score":0.847000002861023},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chromosome-18q","display_name":"chromosome 18q","score":0.9440000057220459},{"id":"https://openalex.org/keywords/candidate-regions","display_name":"candidate regions","score":0.39399999380111694},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/rank","display_name":"RANK","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.623257040977478},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.5878278017044067},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5720603466033936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5574221014976501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5353816747665405},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4391898810863495},{"id":"https://openalex.org/C169857963","wikidata":"https://www.wikidata.org/wiki/Q1461038","display_name":"Test statistic","level":3,"score":0.4308268129825592},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3587173819541931},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.2501814365386963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2459717094898224},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19345802068710327},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19135069847106934},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16814425587654114},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09127569198608398},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002887","descriptor_name":"Chromosomes, Human, Pair 18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013029","descriptor_name":"Space-Time Clustering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/gepi.20373","doi":"https://doi.org/10.1002/gepi.20373","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.20373","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:18839399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18839399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2924681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2924681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Genet Epidemiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2924681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2924681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Genet Epidemiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G125397083","display_name":"NARAC The Genetics of Rheumatoid Arthritis","funder_award_id":"R01AR044422","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1288036168","display_name":null,"funder_award_id":"N01-AR-22263","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1549053710","https://openalex.org/W1569742107","https://openalex.org/W1964511379","https://openalex.org/W1972373469","https://openalex.org/W1977522965","https://openalex.org/W1989413947","https://openalex.org/W1994402720","https://openalex.org/W2005985150","https://openalex.org/W2010801235","https://openalex.org/W2014923067","https://openalex.org/W2021658241","https://openalex.org/W2029322422","https://openalex.org/W2029361834","https://openalex.org/W2045540294","https://openalex.org/W2049872934","https://openalex.org/W2051904003","https://openalex.org/W2059744329","https://openalex.org/W2062298637","https://openalex.org/W2066033942","https://openalex.org/W2080327227","https://openalex.org/W2082513847","https://openalex.org/W2089354715","https://openalex.org/W2096351201","https://openalex.org/W2112348586","https://openalex.org/W2115837368","https://openalex.org/W2134599124","https://openalex.org/W2159539492"],"related_works":["https://openalex.org/W2021396262","https://openalex.org/W2062298637","https://openalex.org/W2005985150","https://openalex.org/W2121375561","https://openalex.org/W7055405198","https://openalex.org/W2158926701","https://openalex.org/W7015368893","https://openalex.org/W2102294296","https://openalex.org/W2145127560","https://openalex.org/W3155928037"],"abstract_inverted_index":{"The":[0,46],"concept":[1],"of":[2,24,41,58,70,77,85,96,102,107,110,118,161,185],"haplotype":[3,13],"sharing":[4],"(HS)":[5],"has":[6],"received":[7],"considerable":[8],"attention":[9],"recently,":[10],"and":[11,26,93,105,150,178,205],"several":[12],"association":[14],"methods":[15],"have":[16],"been":[17],"proposed.":[18],"Here,":[19],"we":[20,72,98,127,189],"extend":[21],"the":[22,66,78,83,86,91,100,103,121,135,165,183,186],"work":[23],"Beckmann":[25],"colleagues":[27],"[2005":[28],"Hum.":[29],"Hered.":[30],"59:67-78]":[31],"who":[32],"derived":[33],"an":[34],"HS":[35,48,131,142],"statistic":[36,49,133],"(BHS)":[37],"as":[38,65],"special":[39],"case":[40],"Mantel's":[42],"space-time":[43],"clustering":[44],"approach.":[45,137],"Mantel-type":[47],"correlates":[50],"genetic":[51,80,87,123],"similarity":[52,55,62],"with":[53,193],"phenotypic":[54,61],"across":[56],"pairs":[57,117],"individuals.":[59,119],"While":[60],"is":[63,125,175],"measured":[64],"mean-corrected":[67],"cross":[68],"product":[69],"phenotypes,":[71],"propose":[73,128],"to":[74,144,180],"incorporate":[75],"information":[76],"underlying":[79,122],"model":[81,124],"in":[82],"measurement":[84],"similarity.":[88],"Specifically,":[89],"for":[90,116],"recessive":[92],"dominant":[94],"modes":[95],"inheritance":[97],"suggest":[99],"use":[101,153],"minimum":[104],"maximum":[106],"shared":[108],"length":[109],"haplotypes":[111],"around":[112],"a":[113,129,158],"marker":[114],"locus":[115],"If":[120],"unknown,":[126],"model-free":[130],"Mantel":[132],"using":[134,146],"max-test":[136],"We":[138,170],"compare":[139],"our":[140,173],"novel":[141],"statistics":[143],"BHS":[145],"simulated":[147],"case-control":[148],"data":[149,156],"illustrate":[151],"its":[152],"by":[154],"re-analyzing":[155],"from":[157,164],"candidate":[159],"region":[160],"chromosome":[162],"18q":[163],"Rheumatoid":[166],"Arthritis":[167],"(RA)":[168],"Consortium.":[169],"demonstrate":[171],"that":[172],"approach":[174],"point-wise":[176,194],"valid":[177],"superior":[179],"BHS.":[181],"In":[182],"re-analysis":[184],"RA":[187],"data,":[188],"identified":[190],"three":[191],"regions":[192],"P-values<0.005":[195],"containing":[196],"six":[197],"known":[198],"genes":[199],"(PMIP1,":[200],"MC4R,":[201],"PIGN,":[202],"KIAA1468,":[203],"TNFRSF11A":[204],"ZCCHC2)":[206],"which":[207],"might":[208],"be":[209],"worth":[210],"follow-up.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}