{"id":"https://openalex.org/W2002163179","doi":"https://doi.org/10.1530/eje.0.1360649","title":"Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism","display_name":"Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2002163179","doi":"https://doi.org/10.1530/eje.0.1360649","mag":"2002163179","pmid":"https://pubmed.ncbi.nlm.nih.gov/9225730"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1360649","doi":"https://doi.org/10.1530/eje.0.1360649","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1360649","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109891418","display_name":"Ides M. Colin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ides M Colin","raw_affiliation_strings":["Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","Division of Endocrinology, Metabolism & Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Endocrinology, Metabolism & Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058869011","display_name":"Peter Andreas Kopp","orcid":"https://orcid.org/0000-0001-5980-0529","observed_orcids":["https://orcid.org/0000-0001-5980-0529"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kopp","raw_affiliation_strings":["Divison of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","Medicine, Endocrinology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Medicine, Endocrinology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015073797","display_name":"Jakob Zb\u00e4ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jakob Zb\u00e4ren","raw_affiliation_strings":["Research Laboratories, Department of Medicine, Inselspital, University of Berne, Switzerland","University of Bern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Department of Medicine, Inselspital, University of Berne, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109425102","display_name":"A. H\u00e4berli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 H\u00e4berli","raw_affiliation_strings":["Research Laboratories, Department of Medicine, Inselspital, University of Berne, Switzerland","University of Bern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Department of Medicine, Inselspital, University of Berne, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Grizzle","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013189795","display_name":"J. Larry Jameson","orcid":"https://orcid.org/0000-0001-9538-4059","observed_orcids":["https://orcid.org/0000-0001-9538-4059"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Larry Jameson","raw_affiliation_strings":["Divison of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divison of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013189795"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":1.8777,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.84517123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"136","issue":"6","first_page":"649","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nos3","display_name":"NOS3","score":0.6740000247955322},{"id":"https://openalex.org/keywords/thyroid-follicular-cells","display_name":"thyroid follicular cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/multinodular-goiter","display_name":"multinodular goiter","score":0.7599999904632568},{"id":"https://openalex.org/keywords/toxic-adenoma","display_name":"toxic adenoma","score":0.6380000114440918},{"id":"https://openalex.org/keywords/tsh-receptor-mutations","display_name":"TSH receptor mutations","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8270000219345093},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8071990013122559},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8062909841537476},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7390370965003967},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.6856107711791992},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5700408220291138},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5007376670837402},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.4397059977054596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4200414717197418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3943214416503906}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1530/eje.0.1360649","doi":"https://doi.org/10.1530/eje.0.1360649","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1360649","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:9225730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9225730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:boris.unibe.ch:24139","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/24139/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Colin, IM; Kopp, P; Zb\u00e4ren, J; H\u00e4berli, A; Grizzle, WE; Jameson, JL (1997). Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism. European journal of endocrinology, 136(6), pp. 649-55. Bristol: BioScientifica Ltd. 10.1530/eje.0.1360649 &lt;http://dx.doi.org/10.1530/eje.0.1360649&gt;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003350157","https://openalex.org/W2008163971","https://openalex.org/W2040195894","https://openalex.org/W2388369845","https://openalex.org/W7216778402","https://openalex.org/W2089295326","https://openalex.org/W2143056658","https://openalex.org/W2105903340","https://openalex.org/W2970893517","https://openalex.org/W2015554237"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1,21,259,285],"mediates":[2],"a":[3,92,191,211,255,280],"wide":[4],"array":[5],"of":[6,19,63,69,250,264],"cellular":[7],"functions":[8],"in":[9,35,44,56,66,80,84,128,136,151,159,173,183,187,201,240,260,269,276,286],"many":[10],"tissues.":[11],"It":[12],"is":[13,54,237,252],"generated":[14],"by":[15,109],"three":[16],"known":[17],"isoforms":[18],"nitric":[20,258,284],"synthases":[22],"(NOS).":[23],"Recently,":[24],"the":[25,36,131,168,202,222,261,265,274],"endothelial":[26,153,241,248],"isoform,":[27],"NOSIII,":[28],"was":[29,75,126,149,156,170,181,231],"shown":[30],"to":[31,77,197],"be":[32],"abundantly":[33],"expressed":[34,55,238],"rat":[37],"thyroid":[38,58,70,160,244,270],"gland":[39,71],"and":[40,60,96,104,120,144,186,243,273],"its":[41,277],"expression":[42,64,83,103,268],"increased":[43],"goitrous":[45],"glands.":[46],"In":[47,163,205,226,234],"this":[48],"study,":[49],"we":[50],"analyzed":[51],"whether":[52,61],"NOSIII":[53,81,124,147,229,236,251,267],"human":[57],"tissue":[59],"levels":[62,132],"vary":[65],"different":[67],"states":[68],"function.":[72],"Semiquantitative":[73],"RT-PCR":[74],"used":[76],"assess":[78],"variations":[79,275],"gene":[82],"seven":[85],"patients":[86,99,119,140,164],"with":[87,91,142,165,193,254],"Graves'":[88,166],"disease,":[89,167],"one":[90],"TSH-receptor":[93],"germline":[94],"mutation":[95,200],"six":[97],"hypothyroid":[98,122,145,227],"(Hashimoto's":[100],"thyroiditis).":[101],"Protein":[102],"subcellular":[105],"localization":[106,249],"were":[107,133],"determined":[108],"immunohistochemistry":[110],"(two":[111],"normal":[112],"thyroids,":[113],"five":[114],"multinodular":[115,206],"goiters,":[116,207],"ten":[117],"hyperthyroid":[118,139],"two":[121],"patients).":[123],"mRNA":[125],"detected":[127,150],"all":[129,174],"samples:":[130],"significantly":[134],"higher":[135],"tissues":[137],"from":[138,190],"compared":[141],"euthyroid":[143],"patients.":[146],"immunoreactivity":[148,220,230,278],"vascular":[152,262],"cells,":[154],"but":[155],"also":[157],"found":[158],"follicular":[161,175,245,271],"cells.":[162,176,246],"immunostaining":[169],"diffusely":[171],"enhanced":[172],"A":[177],"more":[178],"intense":[179,219],"signal":[180,213],"observed":[182],"toxic":[184],"adenomas":[185],"samples":[188],"obtained":[189],"patient":[192],"severe":[194],"hyperthyroidism":[195],"due":[196],"an":[198],"activating":[199],"TSH":[203],"receptor.":[204],"large":[208],"follicles":[209,217],"displayed":[210],"weak":[212],"whereas":[214],"small":[215],"proliferative":[216],"showed":[218],"near":[221],"apical":[223],"plasma":[224],"membrane.":[225],"patients,":[228],"barely":[232],"detectable.":[233],"summary,":[235],"both":[239],"cells":[242,272],"The":[247],"consistent":[253],"role":[256,282],"for":[257,283],"control":[263],"thyroid.":[266],"suggest":[279],"possible":[281],"thyrocyte":[287],"function":[288],"and/or":[289],"growth.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
